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Biomedical subjects

F Lacour

Publications and source records attributed to F Lacour.

At least 55 records · Page 3Linked to original sources
PubMed1977

[Diminution of the percentage of mononucleated phagocytes in patients with breast cancer].

Phagocytic activity of macrophages obtained directly from blisters induced by cantharide was studied in 19 normal women and 21 patients with untreated operable carcinoma of the breast. The percentage of mononuclear phagocytes from cancer patients was significantly decreased as compared to the percentage from control Women. The reasons for this phagocyte inertia in these patients remain to be determined.

Adult↗
PubMed1975

Reduced incidence of spontaneous mammary tumors in C3H/He mice after treatment with polyadenylate-polyuridylate.

The effect of treatment with the double-stranded polynucleotide complex polydenylate with polyuridylate [poly(A) with poly(U)] on tumor development in C3H/He mice was evaluated. Poly(A) with poly(U) was injected in newborn females, and mice were observed for 380 days. During this experimental period 42 percent of treated mice developed tumors, while the incidence in the control group was 63 percent. This difference was statistically significant.

Animals↗
PubMed1974

Transfection of chicken embryo cells with DNA extracted from avian virus-producing neoplastic cells.

DNA isolated from avian virus-producing leukemic myeloblasts induced the production of viruses, but not morphological transformation, in cultivated chicken fibroblasts. The recovered virus had the same biological characteristics as the original avian myeloblastosis virus (AMV) and produced myeloblastosis and nephroblastomas when injected into chickens. Neutralization experiments with chicken anti-AMV-BAI strain A sera showed an antigenic community between the DNA-transfected virus and the original virus. Virus induced in fibroblasts after treatment with DNA from a viral nephroblastic nephroblastoma line only gave nephroblastoma when injected into chicken. Treatment of chicken embryo cells with DNA extracted from normal chicken embryos did not induce viral production.

Animals↗