Biomedical subjects
F L Rose
Publications and source records attributed to F L Rose.
Possible cytotoxic role of nitrenes.
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Anaerobiosis in a frog, Rana pipiens.
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S-triazolopyrimidines. IV. Synthesis as potential therapeutic agents.
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Elimination of some problems encountered in total replacement of the heart with an intrathoracic mechanical pump: venous return.
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The estimation of suramin in plasma.
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Antibacterial substances related to pantothenic acid.
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Antibacterial activity of substances related to p-aminobenzoic acid.
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A new coupling component and simplified method for the estimation of sulphanilamide drugs.
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DIfferential ability of Ambystoma tigrinum hepatic microsomes to produce mutagenic metabolites from polycyclic aromatic hydrocarbons and aromatic amines.
A number of carcinogenic aromatic amines when activated by liver microsomes from a salamander, Ambystoma tigrinum, are mutagenic for Salmonella tester strains sensitive to frameshift mutagens. However, 2 polycyclic aromatic hydrocarbons (PAH) (benzo[alpha]pyrene (BaP) and perylene) that are rendered mutagenic by mammalian microsomes are not activated by Ambystoma mixed-function oxidases. BaP was chosen for study because it is a well-known environmental carcinogen; perylene, an isomer of BaP, has been implicated as a etiological agent in cutaneous neoplasia in Ambystoma. These results support the observation that amphibians are quite resistant to PAH carcinogenesis and suggest that aromatic amines may be more appropriate model carcinogens.