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Biomedical subjects

F L Iber

Publications and source records attributed to F L Iber.

At least 73 records · Page 4Linked to original sources
PubMed1977

Drug metabolism in heavy consumers of ethyl alcohol.

Data are presented on the rate of removal of tolbutamide from the blood from studies in heavy drinking, unemployed, male alcoholic subjects. In such subjects tolbutamide was removed faster than it was in normal subjects and faster than in patients with cirrhosis who are not drinking. This rapid removal rate persists for 4 to 9 wk after hospitalization and is reproduced with 400 gm of pure ethanol in 2 or 3 wk but cannot be reproduced with lesser amounts of beverage alcohol taken outside of the experimental study. Similar acceleration of the clearance rates was observed for warfarin and for phenytoin but could not be demonstrated for aminopyrine.

Adult↗
PubMed1977

Jejunoileal bypass for the treatment of massive obesity. Prevalence, morbidity, and short- and long-term consequences.

The jejunoileal bypass for patients 125 lb or more above their ideal body weight as an experimental procedure exchnages almost certain weight loss for many known and many yet undescribed problems. Study of the known complications has led to altered operative procedures and management techniques that lessen the impact of nearly all of the complications. All patients need occasional advice on potential complications, and most experience episodes of depletions or diarrhea that require hospital intervention. The improved versions of this surgery have not been present sufficiently long to indicate the real nature of long term changes, and careful evaluation is essential for at least small groups of these patients in order for all interested physicians to provide proper advice to the 10,000 or so patients who have already had this procedure. Careful selection of patients to identify those who will accept follow-up and seek help when needed, and to identify those with sufficient social adaptability to adjust to a change in body image, and a competent, experienced acute and chronic team for management lead to the majority of patients having a very satisfactory result. Many specific complications of massive obesity are specifically helped by this procedure. In America, this is the only treatment effective more than half of the time in the massively obese.

Body Weight↗
PubMed1977

Development and evaluation of a compliance test for patients taking disulfiram.

A breath test for carbon disulfide, a major excretion product of disulfiram, is described and evaluated. All breath excretions were standardized by collecting a fixed amount based on CO2 control. Excretion of CS2 falls rapidly (half life 8 to 18 hours), so that 20 to 30 hours following the last dose of disulfiram the test becomes negative. Approximately 300 tests in hospitalized patients taking disulfiram were positive; 40 tests in patients not taking this drug were negative. In an active disulfiram outpatient clinic more than one third of the patients who claimed to have taken disulfiram on the previous day had, as determined by this test, failed to do so. Of subjects judged by the professional staff to be almost certainly compliant 20% were not taking medication. Of the total of 52 patients tested in clinic only 25 were taking disulfiram.

Adult↗
PubMed1976

Pulmonary function studies before and after jejunoileal bypass surgery.

Nine out of twelve obese patients (75%) demonstrated diminished minute ventilation volume (MVV) prior to jejunoileal bypass surgery. Seven out of the nine patients (78%) showed improvement in the MVV as weight reduction ensued following surgery. Other parameters, including arterial blood gases, did not change after weight loss. Weight reduction as a result of jejunoileal bypass surgery brings about an improvement in pulmonary function.

Adult↗
PubMed1975

Increased rate of alcohol removal from blood with oral fructose and sucrose.

The effect of oral glucose, fructose and sucrose on the disappearance rate for intravenously administered alcohol was studied in eight abstinent alcoholic subjects. The three sugars were ingested on separate days in random sequence. alcohol levels were determined at hourly intervals. During sugar ingestion, the mean rates of alcohol disappearance were: 19 plus or minus 1.4 mg/100 ml per hour (plus or minus SE), with glucose, 23.9 or minus 1.4 mg/100 ml per hour with sucrose, and 25.4 plus or minus 1.4 mg/100 ml per hour with fructose. Compared to glucose both fructose and sucrose increased the rate of alcohol from the blood. The blood levels of fructose were similar after the oral dose of 2 g/kg of fructose or 4 g/kg of sucrose.

Adult↗
PubMed1975

Use of blood component therapy for gastrointestinal bleeding in patients with cirrhosis of the liver.

A prospective study was designed to compare the administration of available fresh blood and component therapy in the treatment of gastrointestinal bleeding in patients with cirrhosis of the liver. Fifty bleeding cirrhotic patients were randomly assigned to treatment: 17 patients recieved 51 percent fresh blood (Group 1), 16 patients received 22 percent fresh blood (Group 2), and 17 patients received 25 percent component therapy consisting of packed cells, fresh frozen plasma, and platelet concentrate (Group 3). The mortality rate was unaffected by the type of blood replacement. Neither the blood replacement requirement (Group 1:51 plus or minus 0.9 units Group 2:5.5 plus or minus 0.8 units, Group 3:7.1 plus or minus 1.1 units) nor the duration of bleeding (Group 1:39 plus or minus 0.8 days, Group 2:6.3 plus or minus 2.4 days, Groups 3:5.8 plus or minus 1.0 days) were significantly different. There was no correlation between the mean age of blood or plasma received and the units of blood replaced or the duration of bleeding. Patients with severe coagulation abnormalties had a significantly increased mortality. Component therapy was as effective as the fresh blood regimen in cirrhotic patients with acute gastrintestinal hemorrhage.

Blood Transfusion↗