Biomedical subjects
F Kuhlencordt
Publications and source records attributed to F Kuhlencordt.
Case report 422: Malignant primary osteoporosis.
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[Paget's osteodystrophia deformans. Occurrence, clinical aspects and complications].
33 monostotic and 27 polyostotic manifestations were found in 60 patients with Paget's disease of bone, 30 of whom were females (mean age 65.7 years) and 30 males (mean age 62.8 years). Pelvis, right tibia, lumbar spine, skull and sacrum were most commonly affected. Alkaline phosphatase activity in serum was raised in 95%, and in 88% hydroxyproline excretion in urine was increased. Due to the variable primary osseous or secondary arthrogenic complaints four groups could be distinguished among the monostotic cases. In polyostotic forms only some of the affected bones caused symptoms, whereas the other locations were only detected radiographically. The indication for calcitonin treatment of Paget's disease can only be made after in-patient investigation and evaluation of skeletal involvement, activity of the disease, complaints and assessment of complications actually present or to be expected according to the pattern of involvement. Under these conditions this form of treatment appeared indicated in 41 of 60 patients.
[Paget's disease--manifestations in the vertebral colum. Computer tomographic investigations (author's transl)].
Computer tomography has been found to be of value in the study of deformities and narrowing of the spinal canal in 52 patients with Paget's disease of vertebral bodies. To a limited extent it can also be used for evaluating the intervertebral foramina. Deformities of the spinal canal were classified into three degrees of severity. The most severe changes were found in the lower thoracic region. The presence of neurological complications is an indication for CT studies.
[Results of long-term treatment of primary osteoporosis with sodium fluoride (author's transl)].
Twenty-three patients with primary osteoporosis were treated with sodium fluoride over 25 months. Mean total dose was 21 g fluoride. Symptoms, body size, biochemical results, radiological changes and skeletal mineral content as well as bone histomorphometry were evaluated in assessing results of treatment. Accordingly, no advance in the disease process was demonstrable in 13 patients, while there was definite improvement in six, but in four there was further progression.
[Bone mineral content during chronic hemodialysis long term observation by 125-i photonabsorptiometry (author's transl)].
40 out of 98 patients on chronic haemodialysis show an obviously lowered bone mineral content of the radius (mean -20.4%), 51 patients attain values in the normal range (mean -1%) and 7 subjects slightly increased values (mean +10.9%). A bone mineral loss of 2.5% could be found after long-term observations of this parameter between 6 to 30 months (mean observation period: 15 months). In general a progressive loss of the bone mineral content may be noticed with an increased duration of haemodialysis. This tendency is more distinct after the 40th year of life because of the simultaneous age-depending physiological decrease of bone mass. Abruptly occurring mineral losses of the skeleton may be due to a high incretion of parathyroid hormone and possibly require subtotal parathyroidectomy.
[The coincidence of Paget's disease and an immunoblastic sarcoma (author's transl)].
Malignant change is to be expected in about 1% of patients with Paget's disease. Usually these are osteosarcomas. Fibrosarcomas, benign and malignant giant cell tumours and chondrosarcomas are less common. The present case concerns the development of an immunoblastic sarcoma in the humerus, which was affected by Paget's disease. Only one other similar case is recorded in the literature. Other myelogenous tumours, such as plasmocytomas, are very rare in association with Paget's disease. Consequently there is no evidence for a causal connection between Paget's disease to these tumours, whereas sarcomas arising from bine tissue may be regarded as a form of malignant degeneration of Paget's disease.
[The diuresis of cyclic adenosine-3'5'-monophosphate (cAMP) in primary and secondary disorders of the parathyroid glands].
The diuresis of cAMP in primary hyperparathyroidism was significantly higher at 7.3 +/- 2.5 mumol/g creatinine X 24 h (P less than 0.005) than that in healthy subjects (3.5 +/- 0.7 mumol/g creatinine X 24 h). After successful operation on the parathyroid gland, cAMP diuresis usually decreased within 24 hours to normal or subnormal values. In primary or secondary hypoparathyroidism subnormal amounts of cAMP (P less than 0.005) were excreted. The method gives false-negative results in functional disorders of the parathyroid glands accompanied or caused by renal failure.
[Physiological changes of mineral content of radius and ulna in relation to age and sex (author's transl)].
The mineral content of the radius and the ulna was measured in 773 persons using 125J photon absorptiometry. Statistical evaluation of the data has provided normal values of mineral content of the forearm bones in men and women between the ages of 15 and 90 years. The course of the mineral content curve is discussed in relation to age and sex.
[Albers-Schoenberg osteopetrosis, a clinical and osteologic, nuclear medicine and genetic family study].
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[Clinical aspects of osteoporosis (author's transl)].
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[Resections of the pancreas: their effects on bone and calcium metabolism (author's transl)].
Four to ten years after partial or total resections of the pancreas calcium and bone metabolism was investigated. A high-turnover osteoporosis is proved by bone histomorphometry. There were no signs of osteomalacia or secondary hyperparathyroidism. Radiocalciumkinetics in all cases showed an increase endogenous fecal loss of calcium. Both, intestinal absorption and renal excretion of calcium were normal. Pathophysiologic relationship between resections of the pancreas and their influence on calcium and bone metabolism has not been sufficiently explained until now. Further investigation will be necessary.
[Mineral content of bone in long-standing diabetes: densitometry of "diabetic osteopathy" (author's transl)].
Using 125I-photon absorption, skeletal mineral content was measured in 57 diabetics requiring insulin. Average age was 33 years, mean duration of diabetes 19 years. Abnormally reduced mineral content was detected in ten of 21 males and 11 of 36 women. This finding is interpreted as being a late complication of diabetes. Pathological fractures were not seen and there were very few complaints referable to the skeletal system.
Osteoporosis - a clinical review.
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Proceedings: Bone mineral determinations on long-term diabetics.
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Correlation of clinical, densitometric, and histomorphometric data in osteoporosis.
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