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Biomedical subjects

F Konishi

Publications and source records attributed to F Konishi.

At least 163 records · Page 9Linked to original sources
PubMed1983

[Primary adenosquamous carcinoma of the ileum--a case report].

A 41-year-old woman with a mass of the right lower abdominal quadrant was admitted to our hospital. Ileocecal resection was performed on December 30, 1975; and she is in good health at present. The resected specimen showed a protruded tumor with a central excavation at the terminal ileum; there was a small cyst in the submucosal layer. Histologically, most of the tumor consisted of squamous cell carcinoma. A small nest of squamous metaplasia and adenocarcinoma was observed at the cyst wall. The pathological diagnosis was adenosquamous carcinoma arising from an enterogenous cyst of the ileum.

Adenocarcinoma↗
PubMed1982

Mechanism of inhibitory effect of unavailable carbohydrate on intestinal calcium absorption.

The effect of unavailable carbohydrates on the intestinal absorption of calcium was studied in rats raised for 7 or 8 weeks on diets containing 10 or 20% of cellulose, glucomannan, or pullulan. The following results were obtained a) Body weight gain was diminished more severely in glucomannan groups than in cellulose groups. b) Serum calcium levels were slightly lower in all groups fed unavailable carbohydrates, whereas serum inorganic phosphorus levels were similar to that of the control group. c) There was a significant reduction of bone ash from rats fed glucommanan or cellulose with 620 glycoside bonds. d) Calcium transport measured in the everted duodenal sac remarkable decreased in the glucomannan 20% group, but slightly increased in the cellulose groups. e) Calcium binding activity was lowered significantly in all groups fed unavailable carbohydrates. f) Alkaline phosphatase and sucrase activities in the duodenum were also markedly decreased by prolonged intake of unavailable carbohydrates. These results indicate that inhibitory effect of unavailable carbohydrates on intestinal calcium absorption is partially due to the loss of calcium binding protein caused by gastrointestinal transit of large amounts of undigested substances.

Animals↗
PubMed1982

Pathology of colorectal adenomas: a colonoscopic survey.

The size, histological type, and grade of dysplasia of a large series of colorectal adenomas removed by colonoscopic polypectomy were matched against other variables such as anatomical site, age, sex, and number of adenomas per patients. Special emphasis was placed on the criteria for grading dysplasia in adenomas and the possible significance of severe dysplasia as a selective marker for increased colorectal cancer risk. The results showed that small adenomas (mostly with mild dysplasia) were evenly distributed throughout the colorectum but that adenomas showing severe dysplasia (mostly the larger tumours, greater than 10 mm diameter) were concentrated in the left colon and rectum, particularly the sigmoid part which is also the segment with the highest risk of colorectal carcinoma in high risk populations. Severe dysplasia in adenomas appears to be a selective histopathological marker for increased colorectal cancer risk. It is closely linked with increasing age and numbers of adenomas per patient, with the large adenomas and particularly those with a villous component in their histology. Severe dysplasia and multiple adenomas could be valuable markers for selecting from the total adenoma population those most deserving of close surveillance in follow-up cancer prevention programmes. Conceptually it would appear advantageous to think in term of the dysplasia-carcinoma sequence in the colorectum rather than the polyp-cancer or adenoma-carcinoma sequence. The implications of these results in the study of the aetiology of colorectal cancer are discussed.

Adenoma↗
PubMed1982

Effect of cimetidine on the regeneration of the gastric mucosa around a peptic ulcer.

Histological changes in gastric ulcers during the healing process with cimetidine treatment were compared with those seen with conventional treatment. Healing time of the ulcers was clearly shortened, and the regeneration of the marginal mucosa of gastric ulcers was strongly stimulated by cimetidine. Heightening of the marginal mucosa resulted from active regeneration of the mucosal cells and made the endoscopic features mimic those of gastric cancer. These results suggest that it is necessary to differentiate clearly peptic ulcer from gastric cancer before beginning treatment of a gastric ulcer with cimetidine.

Adult↗
PubMed1980

Acquired cystic disease of the kidney and renal cell carcinoma on long term hemodialysis four surgical cases of young adults in Japan.

Four surgical cases of acquired cystic disease of the kidney in the third decade are reported, which include renal cell carcinoma in three patients and multiple adenomas and cystadenomas in all patients. The intervening parenchyma of these kidneys was disorganized as end stage kidney and numerous cysts were found in both kidneys. Some of the cysts were lined by hyperplastic epithelium consisting of clear and granular cells arranged in piled up and papillary fashion. These cysts were diagnosed as cystadenoma. Multiple solid adenomas of a 28-year-old male on hemodialysis for 6 years were of various size as if arranged in developing stage of the growth. Summing up all cases included in the literature, the mean duration of hemodialysis of the cases with renal tumor was 5.2 years, while 2.9 years without tumor. With increase of duration of hemodialysis, acquired cystic disease of the kidney is exposed to a high risk of developing malignancy.

Adenocarcinoma↗
PubMed1978

Synergistic effect of vitamin C and aspirin on gastric lesions in the rat.

The effects of varying levels of dietary vitamin C on the incidence of aspirin-induced gastric hemorrhagic lesions were studied in young, male rats. Rats fed diets containing either 20, 40, or 60 mg of L-ascorbic acid per gram of diet did not exhibit focal gastric lesions. Administering a single oral dose of aspirin (30 mg aspirin/100 g of body weight) to rats fed control diets produced gastric lesions. When the rats were given aspirin plus a diet containing either 40 or 60 mg ascorbic acid per gram of diet, there was a significant increase in number of gastric lesions. Since vitamin C and aspirin seem to act synergistically in producing hemorrhagic lesions in the stomach, it is recommended that all individuals taking megadoses of vitamin C be cautioned against taking aspirin concurrently.

Animals↗
PubMed1978

Dietary assessment of coal miners in southern Illinois.

A survey was conducted in southern Illinois with a population of 46 coal miners and ex-coal miners ranging in age from 42 to 86 years. All the subjects were suffering from some degree of respiratory insufficiency. Three 24-hr dietary recalls were obtained from each participant and the mean daily intakes of 11 nutrients and calories were calculated by computer. Selected hematological analyses of blood were performed. Dietary intakes of calcium, vitamin A, and vitamin C were lowest within the population sample. The mean blood values indicative of iron status were within normal range. Physical inactivity among some of the miners accompanied by inadequate calcium intakes could predispose them to calcium-related skeletal infirmities. Inadequate intakes of vitamin A by the majority of subjects were particularly significant in this population. The role of vitamin A in maintaining healthy epithelial tissues is discussed and its possible association with a coal miner's susceptibility to pulmonary complications resulting from chronic exposure to coal dust. The results emphasize the value of assessing the nutritional status of individual coal miners and the need for personal dietary counseling.

Adult↗
PubMed1977

Body weight-gain equivalents of selected foods.

A table of body weight-gain equivalents of selected foods has been developed to illustrate the weight gain to expect when eating single protions of a food above daily maintenance requirements for varying periods. The data were designed to discourage overeating habits, which result in obesity, and may be utilized to reinforce proper dietary habits in counseling of all individuals.

Body Weight↗