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Biomedical subjects

F Komatsu

Publications and source records attributed to F Komatsu.

At least 55 records · Page 3Linked to original sources
PubMed1993

[Clinical results of radical surgery for prostate cancer].

We reported the clinical results of radical surgeries for 44 patients with prostate cancer performed between November 1984 and December 1992. The patients were aged from 57 to 79-year-old (mean 67.2) and classified as clinical stage A2 (6 cases), B1 (7), B2 (12), C (16) and D1 (3) respectively. Radical prostatectomy was performed in 42 cases and radical cystoprostatectomy with urinary diversion in 2 patients, and thirty-nine of 44 cases underwent endocrine or chemoendocrine therapies prior to the surgeries. In all patients with stage A2-B1, the operations were curative, on the other hand, more than 80% of clinical stage B2 patients had pT3 tumors and 33.3% of them had lymph node involvements. With regard to stage C patients, the incidence of lymph node metastasis and positive margin was more frequent. Postoperative adjuvant therapies were added to the patients with pT3,4 tumors and nodal involvements. Patients without residual tumors (n = 20) remained disease-free for 8-89 months (mean 32.8). Of 24 patients who had incomplete resection of tumors, 2 died of other diseases, other 2 were alive recurrent and 20 were alive free from disease for 3-99 months (mean 33.8). The surgical indication for low-stage (A2-B2) prostate cancer has been widely accepted, however that for high-stage cancer (C,D1) has remained controversial. It was our belief that radical surgeries for high-stage cancer could become a potentially curative therapeutic modality in combination with pre- and post-operative adjuvant therapies.

Aged↗
PubMed1990

[Magnetic resonance imaging for retroperitoneal fibrosis: report of two cases].

The first case was a 63-year-old man with edema in the lower extremities, and the second case was a 78-year-old man complaining of general fatigue and loss of appetite. Both cases had bilateral hydronephrosis and renal failure due to ureteric obstruction. Both patients with histologically proven idiopathic retroperitoneal fibrosis were studied by magnetic resonance imaging (MRI). MRI was performed using a superconducting magnet operating at 0.5 tesla and spin echo images were obtained. The retroperitoneal fibrous plaque appeared at an intermediate intensity on T1 weighted image and at a high intensity on T2 weighted image. They underwent intraperitoneal ureteral transposition and postoperative administration of prednisolone. Although their renal functions and hydronephrosis improved after the treatments, the fibrous plaque was still observed on MRI. It was considered that MRI was an excellent method of choice in the diagnosis and follow-up of retroperitoneal fibrosis.

Aged↗
PubMed1990

Autologous blood transfusion in orthopedic and oral surgical patients.

The procedure for autologous blood transfusion in the orthopedic and oral surgical patients in our university hospital is described. The collection of blood was begun from 3 weeks prior to the scheduled surgery. Each time 200 or 400 ml were collected, making three collections possible. The collected blood was stored in liquid form up to the day of the operation and returned to the same patient. Without any difficulty, 600-1200 ml of blood were collected from many patients. All patients were prescribed an oral iron supplement (200 mg/day). No significant decrease in the serum iron and ferritin levels after two or three collections was observed. Eighty-nine percent of the orthopedic patients and 87% of the oral surgical patients were transfused only with autologous blood during the operation. Homologous blood transfusion was performed in the patients with more than 2,200 ml of blood loss. The autologous blood collection of 800 ml may be sufficient enough in at least 80% of these patients.

Adult↗
PubMed1989

Effects of dialyzable leukocyte extracts (DLE) and inosine on stimulated lymphocytes.

The effects of dialyzable leukocyte extracts (DLE) on the lymphocytes were examined. The crude DLE suppressed the blast-formation of the PHA-stimulated lymphocytes and proliferation of the leukemic cell-lines but enhanced that of the fibroblastic cells. A certain fraction of the DLE caused the ATP level of the stimulated lymphocytes to rise, after incubation for 24 hours. The fraction was further purified and the inosine eluted from it. The inosine increased the ATP level and markedly enhanced the lymphocyte blast-formation and proliferation of the fibroblastic cells and leukemic cell-lines. It is suggested that when the DLE show some effects on the lymphocytes, the inosine contained in the DLE may show important effects. The effect of inosine was inhibited by other substances contained in the DLE, especially deoxynucleotides. These substances suppressed the blast-formation of the lymphocytes and the proliferation of the leukemic-cell lines. It remains to determine why the fibroblastic cells were not suppressed by them.

Adenosine Triphosphate↗
PubMed1989

Inhibiting effects of cancer sera on in vitro responses of peripheral blood lymphocytes to recombinant interleukin-2.

The effects of cancer sera on the in vitro induction of lymphokine activated killer (LAK) cells and the killer activity of the LAK cells were determined. When the peripheral blood lymphocytes (PBLs) were incubated with recombinant interleukin-2 in a medium (RPMI 1640 + 10% normal human AB serum) for 96 hours, 53-55% of the LAK activity were induced. LAK induction was inhibited when cancer sera were added to the medium. The inhibition rates varied from slight to high (a mean LAK activity; 37.1%). The cancer sera also inhibited the killer activity of the LAK cells which were already induced in the PBLs. These results suggested the presence of an inhibiting factor against the LAK cells in the cancer serum.

Aged↗
PubMed1988

Incidence of Rh anti-E and anti-c production among Japanese after blood transfusion.

The incidence of Rh anti-E antibody production due to blood transfusion in the patients who were Rh E negative and were transfused with more than one unit (200 ml) of E positive red blood cells was examined. The anti-E was detected in 17 (4.7%) out of 360 patients. The incidence of anti-E was significantly higher in the patients who had previously received transfusion than in those who had not. By a similar method, the anti-c was detected in 4 (1.4%) out of 284 patients. The incidence of anti-E and anti-c production among the Japanese receiving blood transfusion at random is estimated to be 1.17% and 0.35%, respectively.

Adolescent↗