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Biomedical subjects

F Kokot

Publications and source records attributed to F Kokot.

At least 91 records · Page 5Linked to original sources
PubMed1996

[The influence of spa therapy on the endocrine system. II. Erythropoietin].

UNLABELLED: The stimulatory effect of spa therapy on erythropoiesis is well documented. The present study aimed to elucidate the pathogenesis of this effect. The influence of spa therapy on plasma erythropoietin and erythropoiesis was studied in four groups of patients: 35 patients with essential hypertension, 35 patients with inflammatory renal diseases at a stabilized stage and normal excretory renal function. 25 patients with gastrointestinal pathology or cholelithiasis and 33 patients with neurovegetative neurosis. Spa therapy for 20 days in Wysowa was accompanied by a significant increase of plasma erythropoietin, iron, ferritin and saturation of transferrin with iron and by an increase of blood haemoglobin and haematocrit value. These alterations were especially marked in patients with essential hypertension. CONCLUSIONS: 1. Spa therapy exerts a stimulatory effect on erythropoiesis caused, among other factors, by increased erythropoietin secretion and iron mobilization. 2. This stimulatory effect is especially marked in patients with essential hypertension.

Autonomic Nervous System Diseases↗
PubMed1996

[Secretion of atrial natriuretic peptide in patients with active renal stone disease].

The role of the atrial natriuretic peptide (ANP) in Na and water metabolism is well recognized. Much less known is the physiological importance of ANP in the metabolism of other electrolytes e.g. calcium and magnesium, which are presumably involved in the pathogenesis of active renal stone disease (ARSD). The present study aimed to assess the potential role of ANP in the pathogenesis of ARSD. Two groups of subjects were examined. The first one comprised 30 patients with ARSD (diagnosed according to Smith's criteria) while the second one consisted of 21 healthy subjects. Both groups were studied under bed rest (BR) and water immersion (IW) conditions. The examined groups were not different by age, sex, serum electrolyte profile (Na, Ca, Mg) and urinary excretion of Na, Ca, Mg and oxalic acid. Patients with ARSD showed significantly higher basal level of ANP and a significantly higher response of ANP secretion to IW as normals. In spite of this abnormality, patients with ARSD showed a similar increase in water, Na, Ca, Mg and oxalic acid excretion stimulated by IW as compared with normals. In contrast to healthy subjects, patients with ARSD showed no significant correlation between serum ANP levels and urinary excretion of Na, Ca and Mg. In addition, only patients with ARSD showed a significant positive correlation between serum ANP and urinary excretion of oxalic acid during WI. Results obtained in this study suggest, that ANP may be involved in the pathogenesis of ARSD.

Adult↗
PubMed1996

Does industrial environment influence the prevalence of arterial hypertension, plasma cholesterol and uric acid concentration and activity of the renin-aldosterone system?

The present study aimed to assess the influence of a highly industrialized environment on the prevalence of arterial hypertension and plasma levels of cholesterol, uric acid, aldosterone and plasma renin activity. Epidemiological studies were performed in 5008 inhabitants of a highly industrialized city (Piekary Slaskie) and in 5004 inhabitants of non industrialized city (Olesno Slaskie) in the south part of Poland. Only subjects over 15 years were enrolled. The prevalence of arterial hypertension in the industrial population was 17% while in the country city 8.2%. Significantly higher serum cholesterol levels were found in hypertensive and normotensive subjects of the highly industrialized region than in the non industrialized one. Finally in hypertensive women aged < 40 years and normotensive men and women of the industrialized region significantly higher plasma renin activity and plasma aldosterone concentration were found than in corresponding population groups of the non industrialized region. From the results obtained in this study it seems, that the highly industrialized environment seems to stimulate hypertensinogenic factors.

Adult↗
PubMed1996

Biochemical monitoring of diabetic patients.

Tight metabolic control as assessed by estimation of glycated hemoglobin or albumin seems to be the main prophylactic factor in the prevention of most diabetic complications. By regular monitoring of the kidney size, GFR, and urinary albumin excretion, detection of early (reversible) diabetic nephropathy is possible. By appropriate dietary (protein restriction) and pharmacological (ACEI, antihypertensive drugs) treatment development of overt diabetic nephropathy may be prevented or markedly slowed.

Diabetes Mellitus, Type 1↗
PubMed1996

[Nephrotoxicity of contrast media--etiopathogenesis and methods of prevention].

Contrast-induced nephropathy remains one of the most serious adverse event of contrast imaging. Patients with existing renal impairment, with or without diabetes, those with congestive heart failure or myeloma, and patients who receive nonsteroidal antiinflammatory drugs may be at higher risk. The pathogenesis of contrast-induced nephrotoxicity probably involves renal ischemic injury, tubular obstruction and direct tubular toxicity. Some prophylactic procedures based on these pathogenetic hypotheses have been proposed. Up-to-date knowledge on incidence, pathogenesis, risk factors, preventive procedures and therapeutic approaches of radiocontrast nephropathy is reviewed.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1996

[Treatment of non-renal anemia with human recombinant erythropoietin (rHU-EPO].

The paper summarises updated knowledge concerning use of rHuEPO in patients with non-renal anemia. Taking into consideration hematological and clinical effects as well as improvement of general well-being obtained after EPO treatment, administration of this hormone is an essential extension of indication for this type of patients.

Anemia↗
PubMed1996

[Half-time of erythropoietin in patients with chronic obstructive pulmonary diseases].

Presence of elevated plasma levels of erythropoietin (EPO) has been reported both in polycythaemic and normocythaemic patients with chronic obstructive pulmonary disease (COPD). The present study aimed to elucidate in what extent prolonged erythropoietin half-life time (T1/2EPO) is involved in the pathogenesis of elevated plasma EPO levels in patients with COPD. Seven normocythaemic patients (5 men and 2 women) with CODP and 6 healthy controls (4 males and 2 females) were examined. In all examined subjects half-life time of erythropoietin was determined after i.v. administration of EPO in a dose of 50 U/kg b.m. In COPD patients the T1/2EPO value was 5.98 +/- 0.67 hours and did not differ from that found in healthy controls (5.87 +/- 0.35 h). Results obtained in this study suggest participation of factors other than prolonged half-time of erythropoietin in the pathogenesis of polycythaemia in patients with COPD.

Erythropoietin↗
PubMed1996

Alterations of Tamm-Horsfall protein immunoreactivity after partial desialylation and deglycosylation.

The role of the carbohydrate moiety of Tamm-Horsfall protein (THP) was investigated by studying the effect of partial enzymatic desialylation and deglycosylation on its immunoreactivity. In our experiments primarily sialic acid alpha 2,6 linked to a galactose was split off, resulting in a 14% increase of immunoreactivity. It was increased up to 21% by further removal of the sugar residues. We also found that complexes composed of THP and human serum albumin, immunoglobulin G or transferrin reacted with anti-THP antibodies. When these complexes were formed with desialylated or deglycosylated THP an essential increase of this reactivity (about 25%) occurred. Our studies indicate that modifications of the carbohydrate moiety of THP (which might occur in vivo by changes in the glycosylation process e.g. in pathologic conditions) lead to increased exposure of THP to the immune system.

Animals↗
PubMed1996

[The influence of water immersion on serum erythropoietin concentration in patients with essential arterial hypertension].

UNLABELLED: Water immersion (WI) is followed by hypoxemia and haemodilution, and induces alterations in renal haemodynamics (increase of tubular sodium load). These facts justified the performance of studies which aimed to assess the influence of WI on EPO secretion. Serum EPO and atrial natriuretic peptide (ANP) concentration and plasma renin activity (PRA) were estimated in 18 patients with essential hypertension (EH) and in 9 healthy subjects (HS) before, after two hours of WI and two hours after discontinued WI. WI was followed by a significant increase of plasma volume and decrease of PRA which were of similar magnitude in both examined groups. Patients with EH showed significantly higher basal levels of serum EPO (66.7 +/- 11.4 mU/ml in EH vs 20.0 +/- 3.4 mU/ml in HS) and ANP (110.6 +/- 15.4 pg/ml in EH vs 75.6 +/- 8.2 pg/ml in HS). WI was followed by significant increase of both EPO (by 34.0 +/- 8.9 mU/ml in EH and 17.0 +/- 5.4 mU/ml in HS) and ANP (by 106.9 +/- 19.2 pg/ml in EH and 149.4 +/- 16.9 pg/ml in HS). Only in EH a significant correlation was found between serum EPO level and MAP and post-WI natriuresis respectively. CONCLUSIONS: 1. Patients with EH are characterized by elevated basal serum levels of ANP and EPO. 2. Participation of the renin-angiotensin system and ANP in the regulation of EPO secretion could not be proven both in normotensive and hypertensive patients. 3. Involvement of EPO in the pathogenesis of EH seems to be likely.

Adult↗
PubMed1996

[Renin plasma profile and sodium sensitivity of blood pressure in hypertensive patients with or without a family history of hypertension].

The relationship between sodium-sensitive hypertension, renin profile and genetic predisposition to hypertension have not been fully clarified. The present study aimed to establish the influence of family history of hypertension (at least one of the parents suffering from hypertension) on the renin profile, incidence of sodium-sensitivity of blood pressure and plasma concentration of selected biochemical parameters (creatinine, uric acid, glucose, sodium, potassium, calcium and cholesterol). 85 patients with essential hypertension (38 females, 47 males) were enrolled in the study. Secondary forms of hypertension were excluded in all patients by careful clinical and biochemical examination performed in the Department of Nephrology, Silesian University School of Medicine in Katowice. Plasma renin activity (PRA) was estimated twice: first after administration of a normal sodium diet (100-120 mmol of sodium per day) and 8 hours of supine position (PRA I) and a second time after 3 days of sodium restriction (10-20 mmol of sodium per day) and 3 hours of upright position (PRA II). All other biochemical parameters were measured once. Only patients with urinary sodium excretion lower than 60 mmol per day (after 3 days of low salt diet), were enrolled in the study. Sodium-sensitive hypertension was diagnosed in patients with a decrease of mean arterial blood pressure (MAP) of more or equal to 10 mm Hg after three days of sodium restriction. Reduction of MAP of less than 10 mm Hg was classified as sodium-nonsensitive hypertension. Among 85 patients with essential hypertension 49 (57.6%) had a positive (group I) while 36 (42.4%) a negative family history of hypertension (group II). Using the criteria presented in this study low, normal, high and rigid plasma renin activity were found, in 14.3%, 57.1%, 18.4% and 10.2% respectively of patients of group I. In patients of group II the incidence of the above mentioned renin profiles was similar: 13.9%, 58.3%, 19.4% and 8.4% respectively. In patients of group I 16 (32.7%) had sodium-sensitive and 33 (67.3%) sodium-nonsensitive hypertension, while in patients of group II 16 (44.4%) had sodium-sensitive and 20 (55.6%) sodium-nonsensitive hypertension (difference between group I and group II is statistically not significant). Patients of group I did not differ significantly from patients of group II with respect to : sex, age, blood pressure, sodium urinary excretion and plasma concentration of above mentioned parameters. From results obtained in this study we may conclude, that patients with and without history of essential hypertension do not differ with respect to renin plasma profile, incidence of sodium-sensitivity of blood pressure and other biochemical parameters.

Adult↗
PubMed1996

[Requirement for blood in hemodialyzed patients with chronic renal failure in the period before and after introduction to erythropoietin (r-HuEPO) treatment].

The present paper aimed to assess the influence of EPO-therapy on the requirement of blood transfusion in haemodialysed patients with end-stage renal failure. As shown in this paper, introduction of r-HuEPO into the therapy of uraemic anaemia almost completely eliminated the request for blood transfusion in these patients. EPO therapy did not influence significantly to the serum creatinine concentration and mean arterial blood pressure in these patients.

Anemia↗