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Biomedical subjects

F Kokot

Publications and source records attributed to F Kokot.

At least 271 records · Page 15Linked to original sources
PubMed1988

[Are glomerular hyperfiltration and hyperperfusion involved in the development and progression of nephropathies?].

In the present paper the significance of non-immunological factors in the development and progression of nephropathies according to the hypothesis of Brenner et al. especially hemodynamic changes in the glomerula with glomerular hyperperfusion and/or hyperfiltration is discussed and therapeutic conclusions are made. The normalized glomerular pressure conditions (converting-enzyme inhibitors), a normalization of hyperglycemia in diabetics, a retention in the use of protein-rich diet and platelet-aggregation inhibitors, respectively, play a special part in the treatment of chronic nephropathies.

Glomerular Filtration Rate↗
PubMed1988

[Behavior of prolactin secretion and 25-hydroxycholecalciferol level in patients with active kidney calculi].

In 76 patients with urolithiasis the behaviour of the level of 25-OH-D and prolactin, respectively, and the metabolism of calcium and phosphate were investigated after an intravenous calcium load. In these patients a significant lower 25-OH-D level and a significant lower increase of the serum phosphate level after calcium load was observed in comparison with healthy adults. However, in contrast to healthy probands, the prolactin level was suppressed significantly. A participation of these endocrine changes in the pathogenesis of pathogenesis of urolithiasis could be suggested.

Adult↗
PubMed1988

[Iron balance in hemodialysis in chronic uremia].

In 24 hemodialyzed uremic patients the serum levels of iron, ferritin, transferrin and parathyroid hormone were determined and the iron absorption in the gastrointestinal tract after an oral load was studied. Moderately elevated iron levels but extremely high concentrations of ferritin in the blood serum were found. A significant positive correlation was found between serum ferritin and iron levels as well as between serum ferritin and the cumulative volume of transfused blood. No correlation was stated between serum PTH and ferritin levels. No abnormality in iron absorption in the gastrointestinal tract was found. The obtained results suggest the necessity of monitoring ferritin levels as a reliable indicator of whole body iron stores in hemodialyzed uremic patients. Hyperfunction of the parathyroid glands does not seem to play an important role in the pathogenesis of abnormal iron metabolism in hemodialyzed patients.

Carrier Proteins↗
PubMed1987

[Effect of water immersion on plasma renin activity, vasopressin and aldosterone level in diabetics].

In 83 diabetic patients (23 of them were insulin-dependent) and 34 healthy subjects the influence of water immersion (WI) for 2 hrs on plasma renin activity (PRA), plasma aldosterone and vasopressin (AVP) level was examined. In both examined groups WI exerted a suppressive effect on PRA, plasma aldosterone and AVP level. In this respect only quantitative but not qualitative differences between diabetics and normals were observed. Presence of moderately advanced diabetic nephropathy and autonomic neuropathy influenced only slightly WI induced alterations of the renin-aldosterone system and AVP secretion. In all diabetic patients a defective volumetric mechanism of both the renin-aldosterone system and AVP secretion was stated. In addition in diabetic patients with late diabetic complications a defective osmotic mechanism of AVP secretion was observed. These findings suggest participation also of factors other than hypervolemia and decrease of the plasma osmolality in the mechanism of the observed WI induced suppression of the renin-angiotensin system and AVP secretion in diabetic patients.

Aldosterone↗