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Biomedical subjects

F Kinoshita

Publications and source records attributed to F Kinoshita.

At least 91 records · Page 5Linked to original sources
PubMed1982

[Endorphins].

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Animals↗
PubMed1982

[RCT image study by angular interval of sampling].

A multi-purpose gamma camera system which had 2 detectors of opposed position and was capable of radionuclide computed tomography (RCT) imaging was installed in Division of Nuclear Medicine, Chiba Cancer Center Hospital. In this study, the variance of RCT image due to the angular interval of sampling was analyzed. The full width at half maximum (FWHM) and full width at tenth maximum (FWTM) of point source were almost same for all sampling intervals investigated. The distortion of RCT images with uniform activity source could not be detected even for larger intervals. When the RCT images were obtained using a phantom contained 3 line sources and a bar phantom for RCT which were located at right angle with the plane of reconstruction, the images did not change between 1 degrees and 6 degrees of sampling interval, but for 9 degrees or more the distortion of images occurred explicity. For our system, sampling interval of 2 degrees was predicted from the theorectical calculation considering both resolution and statistical noise. But, results from the phantom studies of present work showed that sampling interval of 6 degrees was sufficient to reconstruct RCT images without distortion, and could be applicable to dynamic RCT images.

Models, Structural↗
PubMed1981

Sodium butyrate stimulates hCG and hCG-alpha production in a human choriocarcinoma cell line (BeWo).

To assess regulatory mechanism(s) of hormone production between ectopic and eutopic tumor cells, the effect of sodium butyrate on cell growth and hormone production was studied in BeWo, a trophoblastic cell line and in HeLa S3, a nontrophoblastic cell line. The addition of 2 mM sodium butyrate to HeLa S3 produced a marked increase in hCG-alpha both in the medium and in the cell extract, in contrast to its inhibitory effects on cell growth. Sodium butyrate had a similar effect on cell growth and hormone secretion in BeWo cells, as seen with an increase in release of hCG and hCG-alpha were also increased after exposure to sodium butyrate in BeWo. Thus, the regulation of hormone production in trophoblastic and nontrophoblastic tumor cells probably does not differ.

Butyrates↗
PubMed1981

Role of alpha-adrenergic mechanism in regulating tonic luteinizing hormone release in conscious ovariectomized rats.

The role of brain catecholamines in controlling tonic LH secretion was studied in unanesthesized, freely moving, ovariectomized rats. Pretreatment with reserpine (10 mg/kg), given 24 h before the experiment, significantly suppressed pulsatile LH secretion in these rats. Intraperitoneal administration of clonidine (1 mg/kg), an alpha-adrenergic stimulating agent, significantly raised plasma LH levels in reserpine-treated rats. On the other hand, the administration of apomorphine (1.5 mg/kg), a dopamine receptor-stimulating agent, had no effect on the plasma LH levels. These findings suggest an excitatory role of noradrenaline, operating through alpha-adrenergic receptors, in pulsatile LH secretion in ovariectomized rats.

Animals↗