Search PubMed⌕ Search

Biomedical subjects

F Keuppens

Publications and source records attributed to F Keuppens.

52 records · Page 3Linked to original sources
PubMed1987

Ultrasound in urological oncology.

Transabdominal, transrectal and transurethral ultrasonography play a major role in the diagnosis and staging of urological tumors. The practical limitations and possibilities of the several techniques are evaluated in the oncological work-up of tumors of the kidney, bladder, seminal vesicles, prostate and testis. Ultrasonography has become an important diagnostic tool in urological oncology.

Diagnosis, Differential↗
PubMed1983

Increase in gastrin and somatostatin cell numbers in the antrum of dogs after small bowel resection.

A proximal 50 p. 100 resection of the small bowel was performed in six dogs while six control animals underwent a simple intestinal transsection and reanastomosis. The pre- and postoperative serum gastrin levels were measured in both groups before and after a standard test meal. The stomach was resected in both groups 6 to 8 weeks after the operation. A morphometric method using specific antigastrin and antisomatostatin antibodies was used to estimate the density and the total number of antral gastrin and somatostatin cells. No variation in basal serum gastrin was found after surgery. A 50 p. 100, though not significant, increase in the postprandial gastrin response was observed after intestinal resection whereas a significant (P less than 0.01) 50 p. 100 increase in the gastrin cell density was found in the antral mucosa of these dogs. At the same time, a remarkable hyperplasia of the antral somatostatin cell population was observed in the animals submitted to small bowel resection.

Animals↗
PubMed1983

[Prostate hypertrophy. Surgical experience in Belgium. Multi-center study of 1,140 patients of 80 years and older].

An inquiry organized by the Belgian Society of Surgery brought data on the mortality and morbidity of surgery on patients of 80 years and older for benign prostatic hypertrophy in a total number of 1,140 operations. Consensus exist to see this surgery as planned surgery. The mortality was 73 (6.3%) without statistical difference between endoscopic and open surgery. The morbidity of 824 patients was 165. This last figure relates to the big series in the literature. The mortality is in direct relation to the age of the patients. Evaluation of cardio-pulmonary risk (70.8% of the mortality), operation on indication at earlier diagnosis and prospective studies on the risk of operation in this population group are indicated.

Aged↗
PubMed1980

Antral gastrin cell hyperplasia in patients with peptic ulcer.

The total number of gastrin (G) cells in the stomach was determined by using a histologic counting method and planimetry in ulcerous and nonulcerous patients. The preoperative basal and postprandial serum gastrin values and the gastrin cell mass in the gastrectomy specimen could be compared in 16 surgical patients. There was a significant correlation between the integrated gastrin response to feeding and the total gastrin cell number in the stomach. No correlation was found between the basal serum gastrin level and the total gastrin cell count. A total gastrin cell number higher than 50 million was found in the stomach of three duodenal ulcer patients with preoperative postprandial hypergastrinemia as well as in one patient with normal serum gastrin values. Gastrin cell counts between 6 and 42 million were found in control stomachs and in patients with gastric ulcer. Preoperative feeding tests could be useful to select patients with an elevated antral G cell number.

Cell Count↗
PubMed1978

Estimation of the antral and duodenal gastrin cell population removed by gastrectomy from patients with peptic ulcer.

The total number of gastric and duodenal gastrin cells was determined in the gastrectomy specimens from eight patients with peptic ulcer. Planimetry was used to determine the antral and duodenal surface. The immunoperoxydase method with specific antigastrin antibodies was used for staining gastrin cells, and the mean concentration of nucleated gastrin cells per square millimeter of antral and duodenal surface was determined by light microscopy. The mean number of duodenal gastrin cells in the resected duodenum was 4.8 per cent of the total gastric gastrin cell mass. The concentration of gastrin cells in the antrum was quite variable from one mucosal site to another. The degree of extension of the antral gastritic areas was a major factor influencing the mean concentration value. The total number of gastrin cells in the stomach varied from approximately 7 to 74 million cells. Our data indicate that hyperplasia of gastrin cells cannot be demonstrated by studies performed in small specimens taken for biopsy.

Cell Count↗
PubMed1976

Effect of feeding on catabolism and activity of exogenous gastrin in dogs.

The effect of meal upon the catabolism and activity of exogenous gastrin was tested in 4 antrectomized and 4 non antrectomized dogs with Heidenhain pouches. In both antrectomized and non antrectomized dogs infused with exogenous gastrin, the meal decreased the serum gastrin level. This decrease amounted to about 20%, 60 minutes after feeding and the gastrinemia then returned gradually to control levels. In non antrectomized dogs, infusion of a near maximal dose of gastrin increased the acid response to the meal to a level above the maximal histamine acid output. Exogenous gastrin also increased the acid response to a meal in antrectomized dogs. These data indicate: 1) That feeding increases the metabolic clearance rate of exogenous gastrin. This effect could be at least partly related to changes in the intestinal blood flow. 2) That, after feeding, one or several hormones capable of stimulating the acid secretion but unrelated to gastrin are probably released. These hormones could be of major importance in the response of denervated pouches to feeding.

Animals↗
PubMed1976

Failure to pentagastrin administration to restore postprandial acid secretion from Heidenhain pouches after antrectomy in dogs.

In four dogs with Heidenhain pouche, acid outputs from the pouch were measured in response to feeding boiled liver with or without simultaneous administration of pentagastrin. Antrectomy was performed and the experiments were repeated. Antrectomy decreased the acid response to feeding by 90 percent. The preantrectomy response was restored by infusing pentagastrin but near maximal doses were needed and the maximal response to feeding plus pentagastrin could not be restored. These results indicate that the decrease of the acid secretory response to feeding from Heidenhain pouches after antrectomy cannot be explained fully through suppression of endogenous gastrin release. Antrectomy probably interferes with the intestinal phase of gastric secretion.

Animals↗