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Biomedical subjects

F Kawano

Publications and source records attributed to F Kawano.

At least 109 records · Page 6Linked to original sources
PubMed1990

[Stress distribution of supporting tissues under denture. Application of visco-elastic analysis in prosthetic field].

Viscoelastic finite element method was attempted to apply to the removable prosthodontic field. To examine the accuracy of this analysis, the results obtained from creep test of soft lining materials were compared with the calculated results by using this analysis. Stress relaxation in the supporting tissue under the upper complete denture was simulated by using viscoelastic analysis. The results were as follows; 1. The calculated results were in approximate agreement with experiment. 2. When the occlusal table of the denture was move 0.3 mm to the vertical direction, the calculated results indicated the soft tissue acted as a part of the stress relaxation in the supporting structures. 3. By using viscoelastic analysis, the time dependent deformation of the denture base and stress distributions in the supporting structures could be simulated.

Alveolar Process↗
PubMed1990

[A basic study on pressure distribution of supporting structures under complete denture. 1. Application of pressure dispersion analyzing system by using impedance grid sensor to measure the pressure of supporting structures under complete denture].

In order to measure the pressure distribution on supporting structures under complete denture, we used impedance grid pressure sensor and examined its accuracy and availability. The results were as follows: 1. The sensitivity of this sensor was high when the distance between electrodes was short. 2. This sensor showed large change in output voltage and high sensitivity in the case of soft elastic materials. 3. This sensor showed the high linearlity between output voltage and applied load. 4. This sensor showed hysteresis loop under cycle load. 5. Base line of this sensor that has the urethane rubber as elastic material was changed when the load was applied intermittently. We measured the pressure distribution over supporting bones under upper complete denture by using simulator of maxillary edentulous with this impedance grid pressure sensor. We could observe the pressure distribution and pressure region in detail and visually when the load was applied to the both occlusal tables evenly.

Alveolar Process↗
PubMed1990

Effect of viscoelastic deformation of soft tissue on stresses in the structures under complete denture.

The time dependency of stress distribution in the supporting structures under dentures was simulated, under three loading conditions, by visco-elastic finite element stress analysis. In this simulation, viscoelastic material, was used as a model for soft tissue. The results indicate that the viscous flow of soft tissue and the loading position are factors determining stress intensity in the supporting structures under the denture. The stress intensity in the supporting structures was lowered when the occlusal force shifted towards the palatal side. Simulated results support Pound's lingualized occlusion theory.

Alveolar Process↗
PubMed1989

Rearrangements of T-cell antigen receptor delta chain gene in hematologic neoplasms.

Rearrangements of the T-cell antigen receptor (TCR) delta chain gene were studied in primary neoplastic cells from 137 patients with leukemia or lymphoma. TCR delta gene rearrangements or deletions were observed in all 50 T-cell neoplasms: 5 of 8 CD3- T-cell neoplasms showed rearrangements, whereas biallelic deletion of TCR delta gene was the most common pattern in CD3+ T-cell neoplasm (39 of 42 patients). Rearrangements of TCR delta gene were also detected in 23 of 40 immature B-cell leukemias, including 22 of 25 patients with rearrangements of TCR gamma gene, 2 of 17 mature B-cell neoplasms, and 3 of 30 myeloid leukemias. Thus, TCR delta gene rearrangement or deletion is always found in T-cell neoplasms and is frequently found in immature B-cell leukemias associated with TCR gamma gene rearrangement. Furthermore, TCR delta gene rearrangements associated with the germline configuration of the TCR beta, gamma, and immunoglobulin heavy chain genes were observed in two immature T-cell leukemias, suggesting that TCR delta gene rearrangements precede TCR gamma and beta gene rearrangements. These results indicate that an analysis of TCR delta gene rearrangement provides potential tools to establish the clonality of immature T-cell neoplasms and to identify the normal stages of lymphocyte differentiation.

Antigens, CD↗
PubMed1989

[Relapse of gingival tumor during hematological remission in acute promyelocytic leukemia].

A 56-year-old man was admitted to the hospital in April, 1986, with the chief complaint of fatigue. The diagnosis of acute promyelocytic leukemia (APL) was made based on the proliferation of atypical promyelocytes in the bone marrow. No gingival swelling was found on admission. A complete remission was achieved by the BHAC-DMP therapy and maintained by the consolidation therapy and the intensification therapy. In July, 1987, he noticed a solitary gingival tumor around the left lower second molar. The biopsy showed the massive infiltration of leukemic cells, despite the hematological remission. Combination chemotherapy was not effective but the tumor disappeared by irradiation. A hematological relapse occurred in November, 1987, but the second complete remission was achieved by the AB-triple V therapy. He died because of the second hematological relapse in July, 1988. Along with the wide use of intensive chemotherapy for acute leukemia, tumor forming leukemia during the hematological remission, as seen in this case, would be increasing. Thus, we should not overlook any newly formed tumor in the treatment of leukemia.

Aclarubicin↗
PubMed1989

["AB-Triple V" therapy of relapsed or refractory acute myelogenous leukemia].

Sixteen adults with acute myelogenous leukemia (AML) in relapse or refractory to conventional therapy were treated with AB-Triple V therapy. This regimen consists of aclarubicin, behenoyl cytosine arabinoside, etoposide, vincristine, and vinblastine or vindesine. Patients who obtained complete remission (CR) were then given monthly three courses of AB-Triple V therapy, and further courses of AB-triple V therapy every three months. Eleven of the 16 patients entered CR, three were no response, and two died early after initial AB-Triple V therapy. Among 11 patients who achieved CR, 7 are alive and in CR during 1 to 13 months, one died of hepatic failure, and three patients died of infection in CR. Systemic arthralgia following the administration of vinblastine were frequently observed. These results indicate that this salvage therapy are useful relapsed or refractory AML. Therefore, the role of this combination chemotherapy as a part of the initial post-remission therapy needs to be evaluated.

Aclarubicin↗
PubMed1987

T cell gamma gene rearrangements in hematologic neoplasms.

Rearrangements of the T cell gamma (T gamma) gene were studied in primary neoplastic cells from 75 patients with leukemia or lymphoma. T gamma gene rearrangements were observed in 19 of 21 T cell neoplasms; 14 of 21 immature B cell leukemias, including 4 out of 5 patients with rearrangements of both immunoglobulin heavy-chain (JH) and T cell receptor beta chain (T beta) genes; none out of 16 nonlymphoid leukemias. Thus, T gamma gene rearrangement is frequently found in immature B cells and is not always found in T cells showing T beta gene rearrangement, but it is not detected in nonlymphoid cells. Furthermore, T gamma gene rearrangement in cells with the germline configuration of the JH and T beta genes was observed. These results indicate that the detection of T gamma gene rearrangement does not allow a clear assignment to a particular lineage. However, an analysis of T gamma gene rearrangement provides a further potential tool to establish the lymphoid cellular origin and clonality of hematologic neoplasms and identify the normal stages of lymphocyte differentiation.

B-Lymphocytes↗
PubMed1987

Paroxysmal nocturnal hemoglobinuria: termination in acute monocytic leukemia and reappearance after chemotherapy with N4-palmitoyl-1-beta-D-arabinofuranosylcytosine (PL-AC) and vincristine.

Acute monocytic leukemia developed in a 77-year-old woman about 18 months after a diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) had been made. The classical features of PNH disappeared with the onset of the leukemia. Chemotherapy with N4-palmitoyl-1-beta-D-arabinosylcytosine and vincristine resulted in the disappearance of leukemic cells in the bone marrow, during which time intravascular hemolysis recurred and the results of a Ham's test were again positive. The anemia and thrombocytopenia, however, were not improved. The present case report suggests the disappearance of the leukemic cells to imply not bone marrow remission but the return of PNH.

Aged↗
PubMed1986

Expression of Tac antigen on human immature B-cell lineage leukemic cells.

Expression of interleukin 2 (IL-2) receptor (Tac antigen) on leukemic cells from 4 patients with acute lymphocytic leukemia (ALL) and 3 patients with blastic crisis of chronic myelogenous leukemia (CML-BC) was examined. Cells from 6 out of 7 patients did not carry immunoglobulins on their surfaces, but reacted with monoclonal antibodies (mAb) detecting B-cell related antigens such as B1, OKB2 and Leu12. Cells from two cases expressed Tac antigen immediately after cell separation. Phorbol 12-myristate 13-acetate (PMA) could induce Tac antigen in all cases. SDS-PAGE analysis of immunoprecipitates by anti-Tac mAb demonstrated that the molecular weight of Tac antigen on most of the leukemic cells was similar to that of Tac antigen present on Con A-stimulated normal lymphocytes. These leukemic cells poorly responded to exogenous recombinant IL-2. These findings suggest that IL-2 may interact with the immature and mature B cells, and play an important role in the differentiation of B lymphocytes.

Antibodies, Monoclonal↗
PubMed1986

Absolute neutrophilia in adult T cell leukemia.

The numbers of neutrophils and platelets and the serum calcium (Ca) levels were examined in 12 patients with lymphoma-type adult T cell leukemia (ATL) and 35 patients with leukemic-type ATL. The same parameters were also studied in 17 patients with non-Hodgkin's lymphoma and 22 patients with acute lymphocytic leukemia as controls. The numbers of neutrophils and the serum Ca levels were significantly higher in leukemic-type ATL (P less than 0.01) and lymphoma-type ATL (P less than 0.05) than in the controls. However, no statistically significant correlation between the numbers of neutrophils and the levels of serum Ca in ATL was observed. Thus, these two abnormal clinical features might be caused by different humoral factors.

Adult↗