[Modified radical mastectomy in breast cancer].
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Aged↗
Biomedical subjects
F Kasumi
Publications and source records attributed to F Kasumi.
[Diagnosis of breast cancer].
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Biopsy, Needle↗
Evaluation of dot-immunobinding assay for carcinoembryonic antigen determination in nipple discharge as an adjunct in the diagnosis of early breast cancer. Research Group for Carcinoembryonic Antigen in Nipple Discharge.
We have previously reported carcinoembryonic antigen (CEA) measurement in nipple discharge to be a useful adjunct in the diagnosis of non-palpable breast cancer. As an extension, a dot-immunobinding assay was developed to screen a large number of patients with nipple discharge for non-palpable breast cancer. The principle is as follows. CEA bound to a solid phase monoclonal anti-CEA antibody is detected by a second monoclonal anti-CEA antibody conjugated with horseradish peroxidase. The use of tetramethylbenzidine as a chromogen results in a stable color reaction that can be semiquantitively analyzed by the naked eye. The CEA levels determined by this dot assay correlated well with CEA levels determined using the former Elmotec assay. To determine whether or not the method could also be feasible in the detection of non-palpable breast cancer, a collaborative study from 12 Japanese institutes was organized. The CEA levels in nipple discharges from 155 patients were assayed. Thirteen of 30 patients with palpable breast cancer and 22 of 30 patients with non-palpable breast cancer exhibited CEA values higher than 400 ng/ml, a cut-off value determined using 89 benign controls. The specificity (91%) and sensitivity (73%) of this test were higher than those of mammography or cytology. The incidence of elevated CEA levels in nipple discharge correlated significantly with the incidence of intratumoral antigen expression. Thus, the system could prove useful in screening for early breast cancer.
Body Fluids↗
[Breast conserving method].
World changing trend of breast cancer surgery was reviewed historically and reasons why Japan has made slow progress was discussed. Recent worldwide discussions are without exceptions on the limited surgery and radiotherapy for early breast cancer. It is true that the breast conserving method is epochmaking in breast cancer surgery and of great benefit to patient's quality of life. But, success in the breast conserving depends solely on the well balanced radiotherapy between tumoricidal effect and radiation hazards. The author stressed the contradiction of radiotherapy and proposed the surgical quadrantectomy and axillary dissection without radiotherapy till the time comes when radiation effectiveness and hazard will be resolved. It's natural that intensive pathological examination of the resected specimen on serial sections is mandatory.
Adult↗
Can microcalcifications located within breast carcinomas be detected by ultrasound imaging?
The author succeeded in detecting microcalcifications within breast carcinomas, by ultrasound (US) imaging, at the beginning of 1982, and published the results of his clinical and experimental researches at the Third International Congress on the Ultrasonic Examination of the Breast held on June 10-12, 1983, in Tokyo, Japan. After that, more detailed clinical evidence was acquired and new experiments, using breast phantoms, were carried out. This paper introduces an experiment using phantoms which shows that US can detect and identify even 100-500 mu-sized tiny objects in an "ideal" low echoic area similar to microcalcifications within breast carcinomas. Actual clinical evidence is also presented.
Acrylic Resins↗
[Early invasive mucinous carcinoma of the breast].
Cases of early invasive mucinous carcinoma of the breast have been reviewed. Microscopically, a typical lesion exhibits leakage of cancerous mucus into the stromal tissue from an intraductal carcinomatous component which were shown to be mucus-producing and to be lower papillary projection. Among 5,360 primary breast cancers that had been mastectomized at the C.I.H., 11 or 0.21% were determined as being "early" cases. All of these cases exhibited "pure type" mucinous carcinomas which were found to be highly mucus. The average age of these patients was 41 years (range: 34-51 yrs.), and no cases showed a nodal involvement. During an average follow-up of 8 years, no recurrent case were found. Thus, we have found that these "early" cases revealed an early invasion of a mucinous carcinoma that is highly mucus-producing but without an invasive ductal carcinomatous pattern.
Adenocarcinoma, Mucinous↗
[Ultrasonic examination of the breast lesions].
Todays topics on ultrasonic imaging such as ultrasounds of small cancers, noninvasive carcinoma and microcalcifications in breast cancers are discussed. For small breast cancers, 10 mm for infiltrating type and 15 mm for circumscribed type were necessary to be fully diagnosed by US. Of noninvasive ductal carcinomas, a half of them showed the same US pattern as that of invasive ca. and 20% fibrocystic like pattern. The low echoic areas of noninvasive ca. were more round, more different in size and lower echo level than that of fibrocystic disease. The detection of microcalcifications in breast cancers were finely succeeded by US in 63% of cases. Microcalcifications were described by US at first clinically and then ascertained by breast US phantoms. They were described as fine echogenic spots without shadowing low echoic cancer area.
Adenocarcinoma, Scirrhous↗
[Increases in the modified surgery in early cancers].
Early cancers are small in size and localized; many of them have no infiltration or metastasis. It has been gradually clarified what procedure of reduced operation can be feasible without fail to its radicalness to what type of early cancer, as a result of detailed studies on the findings concerning the development of early cancers as well as evaluations of recurrent cases and distant results. Techniques of reduced operation for the treatment of cancers of the thyroid, mammary glands, female reproductive organs and stomach have been improved as early cancer patients increase in number and our understanding of the pathogenesis of early cancers is promoted.
Breast Neoplasms↗
[Estimates of circulating breast cancer-associated antigen CA 15-3 as a monitoring marker in patients with breast cancer].
CA 15-3 is a newly developed tumor marker detected by breast tumor-associated antigen 115D8/DF3 and is being studied as a monitoring marker in breast cancer patients (pts), even though its sensitivity as a screening marker is not so high. The cut off value of CA 15-3 was set at 27 U/ml. We assayed the plasma CA 15-3 levels of breast cancer pts from June 1985 for the purpose of estimating it as a monitoring marker in comparison with CEA. In the monitoring of over 2,000 postoperative pts, 23 were discovered to have metastatic lesions. For prediction of recurrence, CA 15-3 was useful for 11 pts (48%), while CEA was useful for 8 pts (35%), and CA 15-3 or CEA were useful for 14 pts (61%). Although it was little useful for local recurrence, CA 15-3 was highly useful for the prediction of organ & bone recurrence in 7/11 pts (64%). With regard to monitoring of the clinical course of metastatic carcinoma of the breast, the levels of CA 15-3 were positive in 47/68 pts (69%), while in contrast CEA was positive in 42/68 pts (62%). The trend of CA 15-3 was also highly correlated with the clinical course. CA 15-3 thus appears to be a better marker, especially as a monitoring marker, than CEA for breast cancer. Additional research will be required on this marker, but it seems likely that CA 15-3 combined with CEA would provide better information for the monitoring of breast cancer patients.
Antigens, Neoplasm↗
[Study of the ultrasonic findings of metastatic liver cancer].
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Humans↗
[Factors deciding survival rate after resection of pancreatic neoplasms. 3). Invasion of neoplasms in the tail of the pancreas and common bile duct in cases of resected pancreatic head neoplasms].
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Common Bile Duct↗
[Pulmonary malignant lymphoma--a case report].
A case of pulmonary malignant lymphoma is reported. A 65-year-old woman had no complaint. But chest roentgenography and CT revealed an infiltrating shadow with marked airbronchogram in the left S3. TBLB revealed marked subepithelial lymphocytic infiltration of the bronchial wall. Because the shadow had gradually enlarged, malignancy was suspected and lobectomy was performed. The resected specimen showed a 60 X 56 X 30 mm greyish-yellow, medullary tumor with intrapulmonary metastasis. Microscopically, well-differentiated small lymphocytic tumor cells severely infiltrated the pulmonary parenchyma, pleura and bronchial cartilage. There was no lymph node metastasis or extrapulmonary involvement. Immunohistochemical study proved the monoclonality of the K chain. She was treated with chemotherapy postoperatively.
Aged↗
[The accuracy of frozen sections in the diagnoses of breast lesions].
To evaluate the accuracy in diagnosing breast lesions by frozen sections, 657 consecutive diagnostic biopsies seen during 1982 were reviewed. Of 559 lesions considered benign at frozen sections, 558 were also benign in paraffin sections, the remaining one being a papillary carcinoma (i.e. 1/559 or 0.2% false negative). All 78 cases diagnosed as malignant in frozen sections were also malignant in paraffin sections (i.e. 0% false positive). Of the 20 doubtful cases, in frozen sections, 15 showed a papillary lesions; 7 of them were malignant in paraffin sections and the rest 13 benign. It is concluded that the frozen sections are usefull in the diagnoses of mammary disorders except for those cases with papillary tumors.
Biopsy↗
Plasma testosterone and breast cancer.
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Breast Neoplasms↗
[Bilateral breast carcinoma].
Out of 4,777 cases of female breast carcinoma operated at the Cancer Institute Hospital, Tokyo from 1946 to 1980, 170 cases, 3.56% had bilateral breast carcinoma. According to our criteria, 157 cases (92. 3%, 3.29%) were classified as primary and 103 cases (7.6%, 0.27%) were metastatic. Our criteria depend upon the histological proof whether intraductal cancer parts in the smaller or in the second cancer exist or not. Out of 157, 48 cases (1.01%) were simultaneous (within one year) and 109 cases (2.28%) were subsequent bilateral carcinoma cases. The clinical characteristics of primary bilateral breast carcinoma were earlier onset, earlier stage and better prognosis than those of unilateral cases. From the epidemiological point of view, bilateral cases showed high percentage in sterile case and familial disposition. In so called breast cancer family, bilateral cases were common and the tendency of earlier onset in succeeding generation was recognized. The annual incidence rate of bilateral breast carcinoma among amputated patients for unilateral carcinoma was calculated as 4%. So it is well said that the incidence of breast carcinoma among Japanese women is as low as one-sixth of that of Americans, but the rate of bilaterality is high and almost the same as Americans.
Adenocarcinoma↗
[A clinicopathological study of 160 cases of mucinous carcinoma of the breast].
A clinicopathological study was performed on characteristics of mammary mucinous carcinoma and its 3 pathological subgroups: "gelatinous type"--with predominant mucin component, "epithelial type"--with predominant epithelial component, and "combined type"--with a small part of infiltrating ductal carcinoma and mucinous pattern. Among 4,653 primary breast cancers mastectomized at the C.I.H. between 1946 and 1981, 160 or 3.4% was mucinous carcinoma. They were divided into 106 gelatinous type, 20 epithelial type and 34 combined type. 10-year survival rate of mucinous carcinoma (75.3%) was better than whole breast cancer (65.6%). And it was 90.7%, 82.4% and 67.6% in gelatinous, epithelial and combined type, respectively.
Adenocarcinoma, Mucinous↗
[Ultrasound diagnosis of breast cancer].
In this paper, first, how to take good ultrasonic pictures of the breast and make correct diagnosis are discussed. The author stressed the earnest attitude to understand and master the apparatus and correlate ultrasonic pictures with cut surfaces or microscopical figures of the specimen. Secondly, diagnostic criteria preliminarily adopted by the Japan Society of Ultrasonics in Medicine are proposed and are explained practically. The elements of this criteria are shape, border, boundary echoes, internal echoes, posterior echoes, bilateral shadows, changes at surrounding tissues and longitudinal-transverse ratio. Lastly, pictures of the benign and malignant lesions of the breast are shown using typical examples.
Abscess↗
The influence of family history of cancer, irradiation and anticancer medication (mitomycin C), on the occurrence of multiple primary neoplasms with breast cancer--statistical analysis by the person-year method.
The influence of family history of cancer, radiation therapy and anticancer drug therapy (mitomycin C) on the occurrence of multiple primary neoplasms, following treatment of a first primary cancer of the breast, was analyzed by the person-year method in 1,359 patients, in Japan. During 14,371.8 person-years of observation, 111 multiple primary neoplasms including bilateral breast cancers were found in 109 patients. The incidence rate of multiple primary neoplasms were 0.00772 per person-year. The incidence in patients with a family history of cancer was 1.29 times greater than that in patients without such a family history, and the incidence in patients with a family history of breast cancer was about three times greater than that in those without it (p less than 0.01). Radiation therapy raised the occurrence of subsequent primary neoplasms 1.28-fold (or 1.62 fold after 5 years), and mitomycin C (a total dose of 0.8 mg/kg) therapy caused no increase in the occurrence of subsequent primary cancers, after an observation of 10 years or so.
Adult↗