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Biomedical subjects

F Kaneko

Publications and source records attributed to F Kaneko.

At least 127 records · Page 7Linked to original sources
PubMed1980

Analysis of immunological responses in psoriatic lesions: (1) immunopathological studies on psoriatic lesions.

In order to understand immunological responses in psoriatic lesions, immunofluorescent findings have been compared in early psoriatic lesions and fully developed plaque lesions. IgG and IgA were detected as the main antibodies in the horny layer by immunohistology. The IgA at the site of leukocyte accumulation in the horny layer seemed to be associated with secretory component (S-component) and joining chian. Regarding complement, the alternate pathway might be related to the immune reaction as the initial response, because deposits of C3, properdin and glycine rich beta-glycoprotein were found more frequently than C1q-deposit in the both lesions. In the dermis S-component was also detected at the dermal papillae adjacent to the dermoepidermal (D-E) junction of the lesions and no deposit of S-component was observed in uninvolved skin of psoriatic patients. This, however, is not a specific pattern in psoriatic lesions since deposits of S-component were found at the dermal papillae and D-E junction in other dermatoses. These findings might suggest that the immunological response was initiated by secretory IgA in horny layer, which was composed of dimeric IgA and S-component at the D-E junction and which passed easily through the epidermal cells.

Adolescent↗
PubMedDate not supplied

Magnetic resonance imaging for diagnosing skin tumors.

The depth and three-dimensional morphology of skin tumors were studied with MR imaging. This technology was found to be an effective tool not only for evaluating depth but also for determining the degree of invasion of malignant tumors in the skin and soft tissue. Of the various tumors examined, this method was particularly useful for visualizing malignant melanoma and malignant fibrous histiocytoma. Thus, it is likely that MR imaging has great potential as an auxiliary tool for the diagnosis of other types of malignant skin tumors. By means of three-dimensional displays, tumors were more clearly visualized with respect to their relationship to the surrounding tissue and the three-dimensional state of infiltration, which was particularly useful in deciding on an appropriate resection area prior to surgery. The authors expect further technologic improvements in MR imaging in the future which will serve to increase the benefits obtained in its clinical applications.

Abdominal Neoplasms↗
PubMedDate not supplied

Meningioma with granulofilamentous inclusions.

The authors report a case of intracranial meningioma with granulofilamentous inclusions. A 50-year-old man had right trigeminal neuralgia due to trigeminal nerve compression by a petroclival tumor and received tumor resection. Microscopically, tumor cells containing eccentric nuclei and intracytoplasmic hyaline inclusions were arranged in sheets and whorls. The inclusions were negative for periodic acid-Schiff reaction. No histological anaplasia was seen. Immunohistochemistry showed epithelial membrane antigen reactivity on the cytoplasmic membrane. Immunoreactivity for vimentin was recognized in cytoplasm adjacent to inclusions. However, confocal laser microscopic study revealed immunoreactivity for vimentin even inside some inclusions. Ultrastructurally, interdigitation of cytoplasmic processes and desmosomes connecting adjacent cells were noted. Inclusions were composed of numerous fine osmiophilic granules attached by intermediates filaments. These findings were consistent with a meningioma with the granulofilamentous inclusions described earlier. The findings demonstrated by confocal laser microscopy and electron microscopy suggest that these granular materials may be the metabolic products of vimentin filaments.

Humans↗