Biomedical subjects

F Kainberger

Publications and source records attributed to F Kainberger.

At least 73 records · Page 4Linked to original sources

PubMed1999

[Occult fractures of the wrist joint: high resolution image magnification roentgen versus MRI].

PURPOSE: To compare the diagnostic value of high definition macroradiography and MRI in patients with the suspicion of occult wrist fractures. MATERIALS AND METHODS: In a prospective study, 23 patients with clinically suspected wrist fractures and normal initial plain radiographs underwent high resolution macroradiography and MR imaging shortly after trauma. Macroradiographs were taken with a microfocus tube using an anode of 0.03-0.3 mm providing a 4x magnification of the wrist, which was obtained in 4 projections. MR images were performed on a 1.0 T MR unit in coronal planes using T1 weighted SE, T2.-weighted 3D GE, and Turbo-STIR sequences. Follow-up radiographs after 6 weeks were used to confirm the diagnosis of a primary occult wrist fracture. RESULTS: Macroradiography depicted 5 wrist fractures: 4 fractures of the scaphoid bone and 1 fracture of the capitate bone. MRI demonstrated 11 fractures (one of them false-positive): 9 fractures of the scaphoid bone and two fractures of the capitate bone. Using macroradiography, the sensitivity for the detection of occult fractures of the wrist was 50% with a specificity of 100%, using MRI the sensitivity was 100% with a specificity of 92%. CONCLUSION: MRI seems to be superior to high resolution macroradiography in the detection of occult scaphoid fractures and thus is recommended in the management of patients with clinically suspected scaphoid fractures not evident on initial plain films.

Adolescent↗

PubMed1999

Importance of subchondral bone to articular cartilage in health and disease.

The almost absolute barrier to diffusion of nutrients between articular cartilage and subchondral bone does not exist. These anatomic regions represent a functional unit. Repetitive overloading in degenerative disease leads primarily to lesions in the subchondral region (including vessels), which in turn impede flow of nutrition to articular cartilage. As a result, in degenerative joint disease the subchondral region shows reactive enhanced vascularization and heightened metabolism with insufficient repair. In aging, however, vascularization and metabolism are decreased; no repair takes place. In many cases, MRI allows visualization of these subchondral abnormalities. It also demonstrates the basic similarities of degenerative osteoarthritis, osteochondritis dissecans, and avascular necrosis. These different entities may have the same basic etiology but with different disease severity.

Arthrography↗

PubMed1999

Magnetic resonance imaging of the postoperative knee.

Due to the recent development of arthroscopic techniques in meniscal surgery and anterior cruciate ligament reconstruction, an increasing number of postoperative patients are referred for a magnetic resonance examination of the knee because of recurrent injury. Contrary to the nonoperative patient, T2-weighted sequences and, in unequivocal cases, magnetic resonance arthrography play the most important role in the evaluation of a possible meniscal retear. In patients with anterior cruciate ligament reconstruction, the changes of the magnetic resonance appearance of the anterior cruciate ligament graft during the first year after surgery must be considered in the diagnosis of retears. Recent developments in articular cartilage defect repair and the possible role of magnetic resonance imaging in the follow-up are discussed.

Anterior Cruciate Ligament↗

PubMed1999

Six-year results of a cementless stem with prophylaxis against heterotopic bone.

The hypothesis of a possibly diminished bony ingrowth revealed by the development of radiolucency or a radiodense line with time around a cementless femoral stem subsequent to indomethacin administration for prevention of heterotopic ossification was investigated. Eighty prospective patients with indomethacin prophylaxis were compared with 82 patients without indomethacin prophylaxis chosen retrospectively. The same cementless implant was used in all cases, and patients were observed clinically and radiologically for a minimum of 6 years. The mean postoperative Harris hip score at 6 years was 91 versus 88 points, respectively, and there were significantly more excellent results (Harris hip score > 90) in the indomethacin group. None of the patients underwent revision surgery. Radiologic signs such as loss of bone density and radiodense lines were observed around the shoulder of the prosthesis in a similar percentage in both groups. Significant subsidence of the stem was observed in one instance in the indomethacin group and in three instances in the control group. The results of this study are a strong indication that indomethacin does not influence the development of radiolucency or other radiologic changes around a cementless stem after 6 years.

Adult↗

PubMed1999

Diagnostic agreement of quantitative sonography of the calcaneus with dual X-ray absorptiometry of the spine and femur.

OBJECTIVE: The aim of our study was to evaluate the diagnostic agreement between quantitative sonography of the calcaneus and dual X-ray absorptiometry (DXA) of the spine and femur for revealing osteoporosis. SUBJECTS AND METHODS: In 1252 patients (795 women, 54.9+/-15 years old; 457 men, 50.5+/-15 years old [mean+/-SD]), bone mineral density measurements of the lumbar spine (posteroanterior, L1-L4) and the proximal femur (neck, trochanter, intertrochanteric region, total proximal femur, and Ward's triangle) and quantitative sonographic measurements of the stiffness of the calcaneus were performed. The presence of osteoporosis is defined, according to the World Health Organization criteria, as a T-score lower than -2.5. The percentage of patients below the threshold (prevalence of osteoporosis) was calculated for each imaging technique. The diagnostic agreement in identifying individuals as osteoporotic was assessed using kappa scores. RESULTS: Forty-nine percent of the women and 42% of the men were classified as osteoporotic by quantitative sonography, 32% of women and 30% of men by DXA of the spine, and 23-54% of women and 16-54% of men by the different regions of interest revealed on femoral DXA. Kappa analysis showed the diagnostic agreement among these measures to be generally poor (kappa = .28-.41 [women] and .25-.45 [men]). CONCLUSION: The considerable diagnostic disagreement between quantitative sonography and DXA could cause confusion in the daily practice of radiology and make establishing the correct diagnosis a difficult task. The choice of imaging technique influences which patients are diagnosed as osteoporotic.

Absorptiometry, Photon↗

PubMed1999

Aneurysmal bone cyst. A population based epidemiologic study and literature review.

Aneurysmal bone cyst is a rare nonneoplastic expansile osteolytic bone lesion of unknown etiology. To the best of the authors' knowledge, no epidemiologic study concerning its incidence has been reported. The authors performed a retrospective, population based analysis of 94 patients with primary aneurysmal bone cyst and a literature review of 1002 patients regarding gender and age predilection. The annual incidence of primary aneurysmal bone cyst was 0.14 per 10(5) individuals. The male to female ratio was 1:1.04, and the median age was 13 years (range, 1-59 years). The results of this study and data compiled from the literature show that aneurysmal bone cysts occur significantly more often in female patients.

Adolescent↗

PubMed1998

[Diagnostic imaging of the larynx. Normal anatomy of the regional spread of pathologic changes].

The primary goal of diagnostic imaging of the larynx is analysis of submucosal structures that are not visible by clinical or endoscopic means. Therefore, image analysis of the larynx should only be performed under knowledge of the results of clinical diagnosis. The anatomic relationships of the laryngeal skeleton, the intrinsic structures, and the surrounding soft tissue are presented synoptically.

Carcinoma, Squamous Cell↗

PubMed1998

[Primary malignant bone tumors. Clinical aspects and therapy. Vienna Bone Tumor Registry].

Diagnosis, concepts of therapy and prognosis of primary malignant bone tumors require intensive cooperation between orthopedic surgeons, radiologists and pathologists with special knowledge in oncology. The present paper demonstrates relevant topics of diagnosis, radiological appearance and therapy of the osteosarcoma, Ewing's sarcoma, chondrosarcoma and malignant fibrous histiocytoma based on the material of the Vienna Bone Tumor Registry and more than 35 years of cooperation between the Institute of Pathology and Anatomy and the Department of Orthopedics at the University of Vienna.

Bone Neoplasms↗

PubMed1998

[Ewing sarcoma. Diagnostic imaging].

Ewing's sarcoma is a highly malignant neoplasm of the bone whose origin is still uncertain. A strong relationship exists between Ewing's sarcoma and tumors of neural origin (Ewing family of tumors). Ewing's sarcoma must be distinguished from other round-cell tumors like lymphoma and neuroblastoma and also must be differentiated from osteogenic sarcomas. On plain radiographs, Ewing's sarcoma appears as a lytic or mixed lytic-sclerotic, rarely as predominantly sclerotic lesion with margins Lodwick grade III. It is located primarily in the diaphyseal and metadiaphyseal regions of the long bones of the lower extremities. A large soft tissue tumor is usually present. Magnetic resonance imaging is the imaging modality of choice to evaluate the extent of the primary lesion, to monitor the response to neoadjuvant chemotherapy and to follow up non-resected Ewing's sarcomas. Bone scintigraphy is necessary to detect skeletal metastasis, and 201thallium scanning has been shown to be sensitive in the monitoring of treatment response. Today, computed tomography is not longer used to image the tumor site; however, spiral CT of the lungs plays a central role as a staging and follow-up tool.

Bone Neoplasms↗

PubMed1998

Effect of long-term growth-hormone substitution therapy on bone mineral density and parameters of bone metabolism in adult patients with growth hormone deficiency.

Reduced bone mineral density (BMD) and the prevalence for osteoporotic vertebral fractures are symptoms of growth hormone deficiency (GHD) syndrome, and GH replacement therapy is now available for GH-deficient adults. We investigated the long-term effects of GH replacement therapy on bone mineral density (BMD) and bone metabolism in 19 adult patients with GHD over a period of 18 months. In response to GH treatment, the initially decreased IGF-I concentrations rose significantly during 18 months of therapy to levels within the normal range (matched for sex and age) (mean change 158.1 +/- 50.8 ng/ml, P < 0.001). Parameters of bone formation such as osteocalcin (OC) and procollagen I-C-Peptide (PICP) showed a significant increase in the first 6 months of therapy, followed by a slight decrease in the next months. Markers of bone resorption (CrosslapsR and deoxypyridinoline (D-Pyr) also increased significantly with a peak value after 6 months and all parameters except PICP remained above baseline values after 18 months. BMD of the femoral neck (FN) showed an increase after 18 months of therapy (mean change 0.01 +/- 0.03 g/cm2 after 18 months, n.s.). However, the increase in BMD was significant only in the lumbar spine (LS) (mean change 0.03 +/- 0.04 g/cm2, P < 0.05 after 18 months). We conclude that GH replacement therapy in adult patients with GHD over a period of 18 months causes a pronounced increase in bone turnover mainly during the first 12 months of therapy and increases BMD of the lumbar spine and the femoral neck after 18 months.

Adult↗

PubMed1998

A case of aneurysmal bone cyst in father and son.

The authors report a familial case of primary aneurysmal bone cyst in father and son, affecting both at the same location at nearly the same age. This fact again raises the speculation of a genetic link as another factor in the pathogenesis of aneurysmal bone cyst.

Adolescent↗

PubMed1998

Fixation of zygomatic fractures with a new biodegradable copolymer osteosynthesis system. Preliminary results.

In a prospective study, a new biodegradable osteosynthesis material for the facial skeleton has been used in 27 patients with zygomatic fractures. In the six-month follow-up period, the first ten patients showed clinically and radiologically uneventful healing of bone. There were no implant-related complications. The main advantages of the new material are its malleability when heated, enabling fast adaptation to the bone surface, and the avoidance of a second operation for implant removal.

Absorbable Implants↗

PubMed1998

High turnover bone disease following lung transplantation.

Recipients of lung transplants are at very high risk for significant bone loss. Nevertheless, data on bone disease after lung transplantation are still limited. We, therefore, retrospectively evaluated the data of 33 patients surviving at least 1 year after lung transplantation (LTx) who were seen in our outpatient clinic for osteologic evaluation. Results of clinical evaluations, radiographs, and dual-energy X-ray absorptiometry (DXA) were related to each other, to clinical variables, and to serum levels of osteocalcin, parathyroid hormone (PTH), and 25-hydroxyvitamin D: 14 of 33 patients (42%) had vertebral fractures, 9 of whom were diagnosed within 2 years after transplantation. Bone mineral density values (DXA) were markedly decreased and predictive of compression fractures. 25-Hydroxyvitamin D levels were low in 13 patients (39%) and PTH was elevated in 7 (21%). Despite corticosteroids and low 25-hydroxyvitamin D, serum osteocalcin was elevated in 12 patients (36%). This was only partially explained by hyperparathyroidism, low sex hormones, and impaired renal function, and may partly be caused by cyclosporin A. We thus conclude that severe symptomatic bone disease is common in lung transplant recipients and due to a complex situation including high turnover bone loss and hypovitaminosis D. DXA can be used to estimate fracture risk for individual patients.

Absorptiometry, Photon↗

PubMed1998

Limited diagnostic value of macroradiography in suspected scaphoid fractures.

In a prospective study 60, patients having suspected occult scaphoid fractures, but with normal conventional scaphoid radiographs, also underwent macroradiography. Clinical and conventional radiographic follow-up examinations and MRI identified 8 occult scaphoid fractures and 23 nonscaphoid lesions. Macroradiography identified only 50% of the occult scaphoid fractures.

Adolescent↗

PubMed1998

Technetium-99m-MIBI in primary and recurrent head and neck tumors: contribution of bone SPECT image fusion.

UNLABELLED: We prospectively investigated 200 patients with the clinical suspicion for head and neck tumors. The final diagnoses were 94 primary and 56 (37 confirmed, 19 excluded) recurrent squamous cell carcinomas (SCCs), 3 primary and 7 (4 confirmed, 3 excluded) recurrent adenoid cystic carcinomas (ACCs), 6 non-Hodgkin's lymphomas, 10 distant metastases, 6 other malignancies, 10 inflammatory and 8 other nonmalignant conditions. METHODS: Bone (600 MBq 99mTc-3,3-diphosphono-1,2-propane dicarboxylic acid tetrasodium salt) and hexakis-2-methoxyisobutyl isonitrile (MIBI) (600 MBq 99mTc-MIBI) SPECT were both performed under identical conditions (triple-head gamma camera; ultra-high-resolution, parallel-hole collimators; three-dimensional postfiltering) and judged independently and after superimposition. The results were compared to the results of biopsy, surgery and CT. RESULTS: The overall sensitivity/specificity of MIBI was 90%/78% for tumor detection and 90%/95% for the identification of malignant lymph node involvement (CT: 79%/66%, respectively 90%/79%). In the subgroup of recurrent SCC and ACC the sensitivity/specificity for tumor detection was 95%/71% for MIBI versus 78%/68% for CT. The isolated assessment of bone SPECT had a sensitivity/specificity of 100%/17% for osseous tumor spread. Image fusion of MIBI and bone SPECT differentiated between regio-local bone involvement and inflammatory changes and increased the specificity of bone SPECT to 100% in primary staging. Tumor size, stage, histology and pretreatment had no statistically significant effect on tracer uptake or diagnostic utility of scintigraphy. CONCLUSION: We propose the combined 99mTc-MIBI and bone ultra-high resolution SPECT as a highly useful imaging approach in the primary and secondary staging in patients with suspected malignancies in the head and neck region. The high specificity for malignancies in the head and neck region may be used in the differential diagnosis between head and neck malignancies and inflammatory disease in patients with the accidental finding of enlarged lymph nodes and no clinical signs of a primary tumor. Image fusion with bone scanning is mandatory for the topographical orientation and increases the specificity of bone scanning to differentiate between inflammatory or malignant causes of increased bone metabolism.

Bone Neoplasms↗

PubMed1997

Salmon calcitonin and calcium in the treatment of male osteoporosis: the effect on bone mineral density.

OBJECTIVE: To assess the effectiveness of salmon calcitonin in the therapy of male osteoporosis. METHODS: Nine male patients aged 20-73 years with vertebral osteoporosis were included in this study. Patients were prescribed 100 units of salmon calcitonin injected subcutaneously three times per week over a period of three months, followed by three months without salmon calcitonin treatment. Thereafter the patients received another salmon calcitonin cycle for three months as described above. All men received calcium supplementation of 1000 mg/day throughout the study period of 12 months. Bone mineral density of the lumbar spine and at the hip was measured at the beginning and the end of the treatment period using DXA (n = 7) or QCT (n = 2). RESULTS: Baseline evaluation revealed a bone mineral density of the lumbar spine of 0.78 +/- 0.09 g/cm2 and 0.62 +/- 0.09 g/cm2 at the hip. Treatment with salmon calcitonin resulted in a significant increase of vertebral bone mineral density to 0.80 +/- 0.09 g/cm2 (p < 0.015). Femoral bone mineral density also significantly increased after salmon calcitonin therapy to 0.64 +/- 0.11 g/cm2 (p < 0.05). CONCLUSION: These results show that calcium and salmon calcitonin increase bone mineral density in male patients with osteoporosis. Calcium and calcitonin may be useful in the treatment of male osteoporosis; however, further studies are necessary before definite recommendations can be made.

Adult↗

PubMed1997

Clinical and sonographic evaluation of the risk of rupture in the Achilles tendon.

Chronic pain in the region of the Achilles tendon is a common problem and often a sign of progressive degeneration of the tendon which may lead to its rupture. We studied the clinical course and sonograms in 36 patients with achillodynia to find a prognostic parameter enabling us to estimate the risk of rupture. The patients were evaluated clinically for swelling and tenderness and by high-resolution real-time sonography. The sonograms were graded according to the tendon thickness as normal (< 6 mm), minimal (6-8 mm), moderate (8-10 mm) to high-grade (> 10 mm) in the sagittal diameter of the transverse section, and alterations of echotexture were described as diffuse, circumscribed, or inhomogenous. At the time of the primary investigation, we found thickening and alterations of the echotexture in 33 of 72 tendons. In 48 tendons we found pain and local or diffuse swelling in the Achilles tendon region (sensitivity 0.58, specificity 0.79). After a follow-up of 48 +/- 8 months, 7 tendons had ruptured spontaneously. Analysis of the sonograms of the patients taken prior to the rupture showed a high-grade thickening in 4 cases, moderate thickening in 2 cases, and a diameter between 6 and 8 nm in one patient. In no case did we find a rupture of a tendon primarily classified as normal. Patients without sonographic changes exhibited a significantly better clinical outcome following conservative treatment. Sonography was found to be a valuable tool for determination of the tendon's thickness and echotexture. In 28% of our patients with thickening, circumscribed lesions of the echotexture, and chronic pain, a spontaneous rupture occurred.

Achilles Tendon↗

PubMed1997

Economic considerations for the diagnosis and therapy of meniscal lesions: can magnetic resonance imaging help reduce the expense?

With magnetic resonance imaging (MRI) the surgeon has such an effective diagnostic tool in the diagnosis of a meniscal lesion that the times of diagnostic arthroscopy should be in the past. A total of 823 patients with clinically diagnosed meniscal lesions were divided into two groups: group A, 143 patients underwent MRI and 75 of those arthroscopy; group B, 680 patients, 201 (30%) of whom were operated after being only clinically examined. MRI was done on a Siemens Medical System Magnetom 1.5 Tesla with a 256 x 256 matrix. Spinal echo and gradient echo images were performed with slices of 2 to 4 mm thickness. All meniscal tears were graded according to Reicher and Crues, respectively. Grades III and IV were judged to be positive for a meniscal lesion. Arthroscopy was carried out under general anesthesia and the usual technique. The MRI revealed the following results: Medial meniscus: accuracy 95%, positive predictive value (PPV) 92%, negative predictive value (NPV) 95%, sensitivity 98%, and specificity 82%, lateral meniscus: accuracy 97%, PPV 92%, NPV 98%, sensitivity 94%, and specificity 98%. The overall values for MRI of the medial and lateral menisci combined were: accuracy 96%, PPV 93%, NPV 98%, sensitivity 96%, and specificity 90%. The clinical examination often failed to diagnose a meniscal lesion: accuracy 64%, PPV 59%, NPV 89%, sensitivity 96%, and specificity 33% for the medial meniscus. For the lateral meniscus the accuracy was 91%, PPV 61%, NPV 98%, sensitivity 89%, and specificity 91%. The overall values for the clinical investigation of the medial and lateral menisci combined were: accuracy 78%, PPV 60%, NPV 94%, sensitivity 93%, and specificity 62%. Investigation of all 201 patients operated from group B with MRI would have cost $160,800. The cost of 30% fewer arthroscopies would have been $562,800--in total $723,600. The operation of all 201 patients cost $804,000. Hence about $80,000 could have been saved by scanning all 201 patients and therefore reduce the rate of diagnostic arthroscopies.

Adolescent↗