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Biomedical subjects

F KELLOGG

Publications and source records attributed to F KELLOGG.

10 recordsLinked to original sources

Decrease in serum cholesterol with surgical stress.

Serum cholesterol levels decreased with the stress of operation, before the procedure or after it, or before and after. This decrease was 17.6 per cent in a group of 28 elective surgery patients and 20.4 per cent in nine ruptured intervertebral disc patients who had an operation. A presurgical drop was noted and considered to be related to psychological stress.

Cholesterol↗

The fibrinolytic enzyme defect of hyaline membrane disease.

An investigation of the pulmonary fibrinolytic enzyme system in 31 infants who died with hyaline membrane formation was reviewed. There was complete lack of plasminogen activator activity in the lungs of 84 per cent of these infants. This phenomenon was shown to result from an abnormal inhibitor. A comparable inhibitor was found in normal placental tissue, and it is postulated that this inhibitor is released into the circulating blood as the result of placental infarction. Fibrin, a basic component of the hyaline membrane, is probably precipitated from a physiological capillary transudate associated with the formation of amniotic fluid by the lungs. The presence of an inhibitor of fibrinolysis would then result in the accumulation of intrapulmonary fibrin and the formation of hyaline membranes.

Amniotic Fluid↗