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Biomedical subjects

F K Orkin

Publications and source records attributed to F K Orkin.

32 records · Page 2Linked to original sources

Physostigmine-atropine solution fails to reverse diazepam sedation.

Patients undergoing dental extraction under intravenous diazepam sedation were studied to determine whether physostigmine, a cholinesterase inhibitor, reverses diazepam-induced sedation. A modified Bender-Gestalt Dot Test was used to measure psychomotor function. Patient self-assessment of recovery and a surgeon's independent assessment of recovery were scored on a 0 to 10 measured scale before and after administration of either a physostigmine-atropine mixture (nine patients) or saline (12 patients). The physostigmine-atropine mixture did not significantly speed recovery or improve psychomotor function when compared with normal saline. The results indicate that, in contradiction to previous case report, the analeptic effect of physostigmine may be specific for anticholinergic drugs.

Anesthesia, Dental↗

Analysis of the geographical distribution of anesthesia manpower in the United States.

The 1970 geographical distributions of total anesthesia manpower, anesthesiologists, and nurse anesthetists by state were analyzed by multiple regression to account for their unevenness. Independent variables included factors relating to prior professional contact in the state, professional satisfaction, practice income, demand for services, and environment. The distribution of training programs accounted for 41 per cent of the variance in the distribution of total manpower, but 55 per cent was explained by the number of operations, location of nurse anesthesia schools, and proportion of total state employment in service occupations (a proxy for the availability of consumer services). Location of training programs and the absence of the other type of personnel were good predictors for the manpower subgroups. The distribution of nurse anesthesia schools, anesthesiologists, number of surgical operations, and the relative value schedule conversion factor together accounted for 60 per cent of the variance in the nurses' distribution. The location of residency programs (or positions) was a better predictor for the anesthesiologists' location than medical schools or factors characterizing the demand for services. The distribution of nurse anesthetists, hospital cost per day (considered a proxy for a satisfying professional life and for regionalization of services), and residency programs explained 81 per cent of the variance in the anesthesiologists' distribution. Although the regression predicts that increasing the number of residency programs in an underserved state should be associated with an increase the number of anesthesiologists, such a policy may be infeasible dur to pending federal health manpower legislation unless matched by decreasing a greater number of programs in relatively oversupplied states.

Anesthesiology↗

Abuse of nitrous oxide.

The results of an anonymous questionnaire showed that up to 20% of medical and dental students have utilized nitrous oxide in a social setting to produce a "high." Nitrous oxide was obtained from a variety of sources, most often from cylinders used in the production of whipped cream. Although none of the 524 respondents described personal injury with the use of nitrous oxide, a few individuals reported cyanosis, nausea, and syncope.

Education, Dental↗