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Biomedical subjects

F Jung

Publications and source records attributed to F Jung.

339 records · Page 19Linked to original sources
PubMedDate not supplied

Haemocompatibility of endovascular coronary stents: Wiktor GX.

The stent to be examined (Wiktor-Stent, Medtronic ESTC, Kerkrade, NL) was mounted into a closed-loop tubular-system and perfused with platelet-rich plasma (PRP). As controls the tubular-system without stent (as non-thrombogenic control) and secondly the tube filled with glassbeads (as thrombogenic control) were evaluated. A decrease in the number of singularly circulating thrombocytes correlated well with an increases in circulating platelet aggregates. The increasing activation of thrombocytes was demonstrated by immunolabelling of surface structures (CD 62) which become prominent on activation of thrombocytes. The increase in case of the non-thrombogenic controls is thought to be due to the action of the roller-pump. This increase was coincident with an increase in immunologically labelled GPIIb/IIIa receptors and well correlated with an increase in platelet activation as demonstrated by the elevated CD 62 label. In spite of the use of anticoagulation principles in the perfusion model, thrombin was generated (measured by the TAT-complex) in all three cases and the completed coagulation (measured by the occurrence of fibrin D-dimers) also happened. The amount of D-dimers was small, however, in the cases of non-thrombogenic controls and of tubes equipped with stents. Only after the contact of PRP with tubes filled with glass-beads a significant increase in D-dimers followed. In conclusion the implantation of a stent led to an activation, adherence and aggregation of thrombocytes to a somewhat greater extent as in the control-system. It has, however, a much less thrombogenic surface than glass-beads.

Adult↗
PubMedDate not supplied

[The officers of health in the department of Moselle].

The 1803 law about medicine practice ended the anarchy appeared in this field and due to the measures taken during the Convention. It was immediately applied in Moselle and could regularize the situation of 101 medical practioners, 81 of whom were "officiers de santé". Paradoxically, this lax planed perpetuation of second-order practitionners who had, however, a limited practice, and did not have all the medicine doctor's privileges. From 1804, they were examined by departmental juries. Later, their recruitment conditions became more serious. They were practising in Moselle as well in the country as in the cities. Especially a lot, at the beginning of our century, they were progressively substituted by doctors. Their practice was often honorable, and one of them should occupy a quite special place: Pierre Morlanne, an obstetrician surgeon, well-known in Metz, who founded a Midwives Sisters' School. The relationships between medicine doctors and "officiers de santé" were generally correct, and the first one had kept them seats at the Medicine Doctors association of Moselle, created in 1852. However, medicine doctors were careful in "officiers de santé" exercice and did not hesitate to intervene in case of going worse. ...

Accreditation↗
PubMedDate not supplied

[Emile Auguste Bégin (1802-1888): health official, physician, historian, librarian].

Born in Metz, in 1802, E.A. Bégin son of an "Officier de Santé", was accepted for the "Military Instruction Hospital" of this town he left in 1822, promoted "Aide-Major" (a surgeon). He was appointed to the same establishment before having been incorporated, in 1824, into the French occupying power in Spain, and, after his return to Nancy and Strasbourg hospitals, in 1828. Then, he carried on studying medicine and became Doctor of Strasbourg Faculty.

France↗
PubMedDate not supplied

Haemodilution in patients with peripheral arterial occlusive disease.

Haemodilution is an efficient conservative therapy of peripheral arterial occlusive disease. Already a single isovolaemic haemodilution (replacement of 500 ml blood for Haes* 0.5, 10%) increases the pain-free walking distance by 85%. These effects can be maintained by a constant therapy over six weeks and following haemodilution once or twice per month. The haematocrit values should be between 38 and 42%. The haemodilution should be done hyper- or isovolaemically. Not more than 250 ml blood and 500 ml Haes should be infused during one session in order to avoid hypovolaemia. This means an infusion of 250 ml Haes, venesection of 250 ml blood via the same access and then infusion of the remaining 250 ml. The whole procedure should not last more than one hour. Blood pressure, heart rate, lung auscultation and percussion as well as creatinine values has to be controlled during an intensive therapy. If the hydroxyethyl starch concentration exceeds 150 g per week pruritus may occur in singular cases, if the concentration exceeds 700 g per week it is observed in 50% of the cases. Provided the preventive measures are observed haemodilution is an efficient and good therapy which also increases the compliance to practice vascular exercise.

Arterial Occlusive Diseases↗
PubMedDate not supplied

Control of therapy with microcirculatory and phlebotropically active drugs in patients with congenital and acquired venous insufficiency.

During the treatment of two patients with Klippel-Trenaunay syndrome interesting observations of the efficacy and the side effects of DHE were made. This led to the decision to carry out a validity study in 12 patients suffering from chronic venous insufficiency (CVI). The patients were treated with 0.25 mg or 0.5 DHE intravenously, and after that with 7.5 mg orally for one week. Before and after treatment measurements of venous capacity, microcirculatory parameters and rheological parameters were performed. Following the i.v. injection of 0.25 to 0.5 mg DHE the venous capacity decreased significantly in a dose-dependent way. The flow of erythrocytes in capillaries measured under resting condition was significantly lower and peak flow of reactive hyperemia decreased. No relation was found between the dose of DHE administered and the particular side effects (stomach trouble, increase in diastolic blood pressure) in 2 of the 12 patients. After oral treatment patients showed signs of subjective improvement of their complaints. On the basis of the results, the validity of non-invasive angiological tests is discussed.

Administration, Oral↗
PubMedDate not supplied

Thrombus formation in deep venous thrombosis. A clinical approach to diagnosis and control of lysis efficacy.

The efficacy of fibrinolysis in deep venous thrombosis (DVT) depends on the age and organization of the thrombus as well as its localization. Up to now, indication for lysis therapy is defined according to the duration of clinical symptoms (less than 7 days). Our lysis results in urokinase therapy (n = 87) with high-dose and long-term regimen (mean 7.8 days), however, have shown no correlation between the duration of clinical symptoms (up to six weeks) and lysis efficacy (p less than 0.05). Therefore phlebographic criteria were established to allow the differentiation of fibrinolytic therapy depending on the site of the thrombus, its localization and the formation of collateral veins. In order to determine the state of thrombus organization, we used a new ultrasound Duplex system device (ARTIS, 7.5 Mhz, Picker International). In vivo experiments with induced thrombosis in human vena saphena magna demonstrate that echodensity of thrombi in ultrasound starts at the 11th-15th day. These findings are in good agreement with pathological studies of thrombus formation. Recent results of 24 patients with DVT indicate that echodensity of thrombus in ultrasound correlates with the course of organization and the efficacy of later lysis therapy.

Adult↗
PubMedDate not supplied

[A comparative study on the therapeutic results between respiratory feedback (RFB) and a placebo treatment].

In a controlled study 24 patients with neurotic and psychosomatic symptoms were treated with Respiratory Feedback (RFB) in 12 consecutive sessions. The observed changes were compared with the results of a control group. Its members were subjected to a nonsystematic treatment causing them to relax (placebo-group). In this group the physical symptoms of three quarters of the patients changed for the worse whereas significant psychic changes were not observed. In the RFB-group, however, significant improvements were to be found in regard to the physical as well as the psychic condition of the patients. The most distictive changes were reduction in the disposition to exhaustion, a decrease of the vegetative symptoms, and a decline of the compleints about heart trouble, poor circulation and pains in parts of the stomach and intestinal system. Psychologically a distinct reduction of fear, neuroticism, increased extraversion scores and a positive change of mood followed. It is being discussed if the observed changes in the RFB-group can be attributed to specific effects of the Respiratory-Feedback (RFB).

Adult↗
PubMedDate not supplied

[Effects of vagotomy and pyloroplasty on a model of experimental chronic gastric ulcer in the rat (author's transl)].

343 white Wistar rats were divided into three groups of 113, 115 and 115 animals in each group. A control group received an injection of acetic acid into the wall of the antrum whereas the two other groups underwent first, in one group, a vagotomy and pyloroplasty, in the other, a pyloroplasty alone. In all the control animals there was observed, during the days following the injection, the existence of a severe antral ulcer. This ulcer improved with time upon 40th day, then around the 70th day appeared a second ulcer cycle. In the operated animals, the ulcers were definitively less frequent, and the course was linear without a second ulcer cycle. In the light of physiological and morphological evidence, it was shown that injection of acetic acid caused a submucosal lesion with a constant linear course towards the development of a callus which became hyalinised all the more quickly when it was submitted to endogenous agression by gastric juice. Above this callus, the gastric mucosa attempts to regenerate and, owing to the poor quality substratum, becomes ulcerated again, thus constituting the various cycles of peptic ulcer disease. Pyloroplasty and to a lesser degree, vagotomy-pyloroplasty, reduce stasis of the gastric juice and reduce endogenous agression of the callus and thus slow the unfavourable course.

Acetates↗
PubMedDate not supplied

[The efficiency of 20 hours of brief psychotherapy with the Guidire Affective Imagery. Examination with psychological tests].

26 non-selected out-patients of a psychiatric and psychotherapeutic clinic with psychoneurotic personality disorders and psychosomatic complaints were treated with the Guidive Affective Imagery (GAI) during 20 sessions. Analysis of the psychodiagnostic tests prior to treatment showed that 7 patients had insignificant psychopathological profiles although they felt bad and had diffuse psychosomatic complaints whereas 12 suffered from neurotical symptoms and severe psychosomatic disorders. The rate of improvement was assessed by standardized tests. The GAI proved to be an effective short term treatment of depressive and inhibited patients. A significant rate of improvement of less neurotic and psychosomatic disorders was found. These results are still to be confirmed by katamnestic questionnaires in order to assure that the therapeutic changes are long lasting.

Adult↗
PubMedDate not supplied

[Primary linitis plastica carcinoma of the colon and the rectum. Report of three personal cases (author's transl)].

Primary linitis plastica carcinoma of the colon is rare. Only 19 cases have previously been described in the american literature and three french cases are reported. Clinically, this entity appears as an inflammatory lesion. It revolves to a stenotic lesion and death by metastases. Eighty-four per cent of carcinomas are beyond the splenic angle and sixty-six per cent are localized on rectum or distal sigmoid. These tumours are accessible to rectoscopic examination and biopsy which is the only examination able to assert the diagnosis of linitis. Histologically, nothing can distinguish a primary colonic localization from a metastasis. Therefore, it is very important to search for a primary localization especially gastric. Surgical resection is efficient with or without X ray-therapy as we have seen it with control of carcino-embryogenic antigene evolution in one of our cases. Prognosis is bad, especially among people over 50 years with metastasis.

Adenocarcinoma, Scirrhous↗
PubMedDate not supplied

N-hydroxylation of the antiprotozoal drug pentamidine catalyzed by rabbit liver cytochrome P-450 2C3 or human liver microsomes, microsomal retroreduction, and further oxidative transformation of the formed amidoximes. Possible relationship to the biological oxidation of arginine to NG-hydroxyarginine, citrulline, and nitric oxide.

Previous investigations have shown that the antiprotozoal drug pentamidine is N-hydroxylated by rabbit and rat liver microsomal fractions. Indirect evidence for the participation of the cytochrome P-450 enzyme system was obtained. In this study, rabbit liver cytochrome P-450 2C3 is shown by reconstitution experiments with highly purified variants of P-450 2C3 isolated from rabbit liver and purified variants of P-450 2C3 expressed by recombinant Escherichia coli to be a microsomal pentamidine N-hydroxylase. The two variants, P-450 2C3 (6 beta H) and P-450 2C3 (6 beta L), are equally efficient for the formation of the monoamidoxime derivative of pentamidine. N-hydroxypentamidine is further oxidized to the respective amide by reconstituted rabbit liver P-450 enzyme systems involving the oxidase and peroxidase activities of this enzyme. Formation of nitric oxide [(NO); endothelium-derived relaxing factor] during this oxidation is shown by the detection of the cytochrome P-420-Fe(II)-NO complex by visible difference spectroscopy. The possibility for the N-hydroxylation of pentamidine to the corresponding amidoximes and subsequent oxidative conversion to the respective amide derivatives is comparable with the physiological transformation of arginine to citrulline via N-hydroxyarginine with liberation of NO (endothelium-derived relaxing factor). The N-hydroxylated derivatives of pentamidine are easily retroreduced by microsomal fractions from rabbit liver. NADH is preferred to NADPH as cofactor for this reduction, and the reaction is strongly suppressed by the addition of N-methylylhydroxylamine. The N-hydroxylation of pentamidine and the retroreduction are also catalyzed by human liver microsomes.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

Haemostatical and rheological aspects of dysfibrinogenemia.

Congenital dysfibrinogenemia is based on different alterations in the structure of the fibrinogen molecule leading to a variety of disturbances in the clotting process. Clinical manifestations of the disorder are showing a wide range from asymptomatic states to mild bleeding diathesis as well as thrombotic complications. In this study two of the 14 patients with dysfibrinogenemia showed a history of mild bleeding while the others showed no clinical symptoms. As fibrinogen is also an important factor of the blood fluidity not only haemostatic but also rheological parameters were measured. Included in the study were 14 patients with ascertained dysfibrinogenemia in comparison to 11 non-affected relatives and a control group of 297 apparently healthy subjects. Plasma viscosity (p < 0.0001) and erythrocyte aggregation index (p < 0.00001) were significantly higher in the patients than in their healthy relatives and the control group. A pathologically increased erythrocyte aggregation was found in 10 of the 14 patients but only in 1 of the 10 relatives. The dysfunction of the fibrinogen molecule thus influences the aggregation process of the red blood cells to a greater extent than normal fibrinogen. Moreover, there seems to be a stronger influence of the dysfunctional fibrinogen molecule on the aggregation process than on plasma viscosity. To date the question if the enhanced erythrocyte aggregation in dysfibrinogenemic patients may be of any diagnostic interest and if there are significant differences between patients with bleeding diathesis and thrombophilia cannot be answered and remains to be cleared in further investigations.

Analysis of Variance↗
PubMedDate not supplied

Influence of neutrophil separation on the expression of adhesion molecules.

In many assays of polymorphonuclear neutrophil (PMN) function the first step is separation of PMN from whole blood. In the present investigation it was examined if PMN separation leads to an altered expression of neutrophil surface membrane adhesion molecules. Samples have been taken from 20 healthy volunteers (10 male, 10 female; 39.7 +/- 11.8 years of age). PMN activation was measured cytometrically using the following antibodies against PMN surface membrane receptors: L-selectin (CD 62 L), beta-2-integrin Mac-1 (CD 11b) and Intercellular Adhesion Molecule 1 (CD54). PMN activation was determined in whole blood and after separation of PMN using density gradients. After PMN separation all three adhesion molecules appeared increased but the effect was only statistically significant for CD 54 (Wilcoxon test). Data (mean fluorescence intensity in arbitrary units) were: CD 62 L: 62 +/- 37 in whole blood, 82 +/- 28 after separation; p = 0.0674, CD 11b: 94 +/- 55 in whole blood, 111 +/- 47 after separation; p = 0.1454, CD 54; 13 +/- 12 in whole blood, 81 +/- 35 after separation; p < 0.0001. With the present data available it can be assumed that separation of PMN from whole blood can influence the results of flow cytometric assays.

Adult↗