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Biomedical subjects

F Jensen

Publications and source records attributed to F Jensen.

At least 109 records · Page 6Linked to original sources
PubMed1979

Achondroplasia and hypochondroplasia. Comments on frequency, mutation rate, and radiological features in skull and spine.

An attempt was made to ascertain all the dwarfs in the State of Victoria. The incidence of achondroplasia proved to be approximately 1 in 26,000 live births in the period 1969 to 1975 when ascertainment was nearly complete. This indicates a mutation rate of 1.93 X 10(-5) per generation in this locus. Paternal age was shown to influence mutation. Ascertainment in earlier years of the study was low despite the very great effort made to find all cases. Patients with hypochondroplasia were particularly difficult to find. However, 25 cases were found for study. Overlap between hypochondroplasia and achondroplasia was found in all features except the facial appearance (which was the basis of definition). Achondroplasia was more severe in all regards, but some individuals with hypochondroplasia were very short and some had extreme degrees of spinal canal stenosis. The classical measurements used to describe the skull changes in acondroplasia failed to distinguish this condition from hypochondroplasia. More efficient indices were devised, but visual assessment of the size of the facial region compared to that of the cranial valult proved more reliable than any index. The clinical distinction based upon facial appearance remains the arbitrary basis of definition.

Achondroplasia↗
PubMed1978

Genetic control of immune responses to Moloney leukemia virus in rats.

When BN and LEW rats were immunized with untreated or with inactivated Moloney murine leukemia virus (M-MuLV), BN rats produced high antibody responses to the p15, p30, and gp70 antigens of the virus, whereas LEW rats were low responders to these antigens. BN rats also exhibited a high response and LEW rats a low response when the two strains were immunized with purified p30. Studies of (LEW X BN)F1 and backcross rats suggested that factors associated with AgB exerted major influences on responses to antigens of M-MuLV and that other factors were also important. When other rat strains representing 5 AgB alleles were tested, some were high and some were low responders to M-MuLV, and responses to p15, p30, and gp70 were not always parallel. Since M-MuLV replication was greater in cells of BN rats than in cells of LEW rats, replication of M-MuLV may have influenced the levels of responses to some viral antigens. Control of virus replication appeared to be due to cell mechanisms rather than to the environment of the host.

Animals↗
PubMed1977

Recurrent intraspinal arachnoid cyst treated with a shunt procedure.

A case of a recurrent arachnoid cyst in the thoracic region in a 13-year-old boy is reported. At the first operation, complete removal of the cyst proved impossible. At a second operation four years later, it was still impossible to remove the cyst so we performed a shunt procedure with drainage through a Hakim valve to the right atrium. This procedure was successful, resulting in complete disappearance of symptoms. In the presence of recurrent intraspinal cysts the authors recommend this treatment, as it is an easy operation which does not cause undue discomfort to the patient.

Adolescent↗
PubMed1977

Post-traumatic syringomyelia. Review of the literature and two new autopsy cases.

Two cases of post-traumatic syringomyelia studied macro- and microscopically are reported and compared with three previous autopsy cases described in the literature reviewed. The histological findings suggest that the pathogenesis may be explained by a pressure gradient in a small primary cavity. Although syringomyelia is a rare complication of traumatic spinal cord lesions, it is important to draw attention to the condition because it may be improved by surgical intervention.

Adolescent↗
PubMed1976

The natural history of reflux and long-term effects of reflux on the kidney.

Spontaneous cessation of vesicoureteral reflux occurred in 42 per cent of 102 patients. It ceased in 65 per cent of the patients with unilateral reflux, in 50 per cent of those with bilateral reflux in normal caliber ureters and in 9 per cent of those with bilateral dilated ureters. Renal parenchymal changes were seen most frequently in patients with urinary infection after diagnosis. The likelihood of such infections lessened if reflux ceased. Proportionately more male than female subjects were free of infection. Renal damage may follow even 1 episode of infection. Lesions appeared with equal frequency during the entire followup period, whereas urinary infection was more common in the 5-year period after diagnosis. Renal damage was more likely to occur in kidneys that were already abnormal. Reflux should be controlled surgically if urinary infections occur after diagnosis and during long-term chemotherapy and careful observation. In the absence of infection indications for operation are infrequent. Non-surgical management may apply to normal caliber ureters and in infancy, while antireflux operation may be considered at diagnosis in dilated ureters, bilateral reflux or in the presence of renal lesions.

Adolescent↗
PubMed1976

Ultrasonically-guided percutaneous nephrostomy. Report of 24 cases.

Ultrasonically-guided percutaneous nephrostomy using the Seldinger technique was attempted on 24 kidneys in 19 patients with obstructive hydronephrosis. Seventeen of the procedures were successful, 4 failed, and in 3 the catheter slipped out of the renal pelvis 1-48 hours after insertion. The procedure is simple and independent of renal function. Postrenal uremia can be relieved, infected hydronephrosis drained prior to elective surgery, and urinary parameters assessed. Injection of contrast material can define pathological anatomy in those cases where excretory urography and retrograde pyelography are unsatisfactory. No significant complications were encountered.

Fistula↗
PubMed1976

Repair of denuded cranial bone by bone splitting and free-skin grafting.

As an alternative to the use of pedicled skin flaps for the repair of large defects of the scalp with denuded cranial bone, we recommend splitting of the bone and exposure of the diploë. The diploë is then covered with a free-skin graft, either immediately or after the formation of granulation tissue. The method is simple; it does not cause undue discomfort to the patient and does not detract from the chance of success if a more elaborate reconstructive procedure should be required later.

Basal Cell Carcinoma↗
PubMed1976

The treatment of thyroid cysts by ultrasonically guided fine needle aspiration.

28 solitary thyroid cysts diagnosed by ultrasonic examination were punctured under guidance of ultrasound, as a therapeutic trial and for cytological evaluation. No case of malignancy was encountered. At follow-up 3--6 months later no cyst could be demonstrated in 20%, 30% of the cysts had decreased, while 50% were unchanged or increased in size.

Biopsy, Needle↗