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Biomedical subjects

F Jara

Publications and source records attributed to F Jara.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Comparative study of iohexol and iopamidol as cardioangiographic contrast media].

We have done a double-blind randomized study to compare the cardiac effects of 2 nonionic low osmolality contrast agents, iohexol (n = 25) and iopamidol (n = 25), for left ventriculography and coronary arteriography. No statistical differences were detected between both groups in quality of image, clinical (absence of nausea; intense warmth [8% vs 8%, p = NS]) and electrocardiography (repolarization changes [24% vs 12%, p = NS], absence of severe bradycardia and ventricular arrhythmia) effects. Ventriculography induced no change in systolic left ventricular pressure (iohexol: 128.6 +/- 18 vs 127 +/- 19 mmHg, p = NS; iopamidol: 133 +/- 24 vs 131.8 +/- 23 mmHg, p = NS), and a little but significant rise in left ventricular end-diastolic pressure (iohexol: pre = 11.6 +/- 7 vs post = 13.9 +/- 7 mmHg, p less than 0.01; iopamidol: 11.7 +/- 4 vs post = 15.5 +/- 5 mmHg, p less than 0.001). Our results suggest that iohexol and iopamidol are comparable and qualified for angiocardiography.

Angiocardiography↗
PubMed1989

Vancomycin therapy for gram-positive peritonitis in patients on CAPD.

We describe the use of vancomycin in the therapy of gram-positive peritonitis in patients on CAPD. Two ways of administration were in comparison: a) the intraperitoneal (IP) route, with the intraperitoneal administration of 30 mg/l vancomycin for 10 days and b) the intravenous (IV) route with 2 infusions of 1 gram of vancomycin, the first one on the day of the diagnosis of gram-positive peritonitis and the second 7 days later. Each one of these therapeutic schedules was applied at random for 20 episodes of peritonitis out of 40 episodes with gram-positive organisms (28 Staph. albus, 10 Staph aureus and 2 Streptococcus). Remission of clinical symptoms occurred in 49-72 hours in both groups, while macroscopic clearing of dialysate effluent and sterilization of cultures were observed in 4-7 days. Recurrence of peritonitis was seen in 4 patients of the IV group 2 weeks after the administration of the second dose of vancomycin. We conclude that the use of vancomycin with either of the two ways of administration is of great value in the treatment of gram-positive peritonitis. The IV infusion was less successful but it seems to be useful for the out-patient treatment of gram-positive peritonitis.

Drug Administration Schedule↗
PubMed1989

[Comparative studies of diatrizoate, ioxaglate and iohexol as angiocardiographic contrast media].

We did 2 consecutive randomized studies to compare the effects of diatrizoate, ioxaglate, and iohexol. Sixty patients were studied: 15 with diatrizoate (group I) versus 15 with ioxaglate (IIA), and 15 with ioxaglate (IIB) versus 15 with iohexol (III). Group I had hypotension and severe increase in end-diastolic pressure. Severe bradycardia was seen in 27% of the cases. Group IIA and IIB had identical changes, with a moderate increase in systolic and end-diastolic pressure. Group III only presented a mild increase in end-diastolic pressure. None of the low-osmolar contrast media produced severe bradycardia, but ioxaglate induced frequent (20%) nausea. Our results suggest the best contrast media for angiocardiography is, in decreasing order: iohexol, ioxaglate, and diatrizoate.

Angiocardiography↗
PubMed1981

[Coronary angiography and hemodynamic parameters in patients recovered from a myocardial infarction].

The hemodynamic findings of a group of 112 patients with a prior history of myocardial infarction have been reviewed. The patients have been classified in three subgroups: anterior (48 cases), posterior (43 cases), and biventricular electrical infarction (21 cases). There was only one female in the 112 cases. There was a good correlation between the electrical region of infarction and ventricular asynergy localized to the same territory (76.65, and 90 %, respectively), as well as significant involvement of the corresponding coronary artery (89.88 and 100 %, respectively). A high percentage of patients with significant lesions of the coronary artery opposite the infarction was found (48 % in anterior necrosis, and 76 % in posterior lesions). In five cases the coronary vessels had no abnormalities. Ejection fraction and postangiography end diastolic pressure were the parameters of ventricular function most constantly altered. From this study it appears particularly relevant that there is a low incidence of women: there exists a good correlation between the infarct, the zone of asynergy, and the affected coronary; the number of affected coronaries increases with age; there are significant lesions in the opposite coronary, and there is a greater alteration of ventricular function in patients with biventricular infarction, followed by patients with anterior infarction.

Adult↗
PubMed1980

[Left ventricular aneurysm. Correlations with coronary arteriography (author's transl)].

Ventricular aneurysm is the most severe segmental disorder of ventricular function. A group of 45 patients with ventricular aneurysms have been evaluated, correlating a total of 80 aneurysmatic segments with cineventriculographic findings. Seventy-one percent of the patients had multiple lesions. Except for three patients with normal coronary blood supply and apical aneurysm there was a positive correlation between the remaining aneurysmatic segments and significant lesions in the corresponding arteries. As in the three cases with normal coronary arteries, associated spasm was suspected in other eight cases showing significant vessel stenosis of less than 75 percent of the lumen. Detection of ventricular aneurysm in the cineventriculographic examination is highly suggestive of severe arterial damage.

Adult↗
PubMed1980

[Distribution of significant coronary lesions in patients with rheumatic valvular heart disease. Study of 300 consecutive cases (author's transl)].

Associated coronary atherosclerosis in patients with rheumatic valvular heart disease is an important finding under prognostic and therapeutic viewpoints. Selective coronary angiography was carried out in 300 patients with rheumatic valvular disease (157 cases with associated mitral and aortic lesions; 57 cases with aortic regkurgitation; 35 cases with aortic stenosis; 31 cases with mitral stenosis, and 20 cases with mitral regurgitation). Significant coronary atherosclerosis occurs in 11 percent of all patients. The distribution of the lesions was as follows: anterior descending artery (56 percent); right coronary artery (47 percent); circumflex artery (28 percent); marginal artery (22 percent); oblique branches (19 percent), and common left trunk (3 percent). Lesions in the common left trunk were only present in association with aortic regurgitation. Fourty-four percent of patients with significant atherosclerosis showed multiple lesions, and there was a distal coronary tree appropriated to coronary bypass in 78 percent of the cases. The distribution of significant coronary lesions in patients with rheumatic valvular heart disease is similar to that observed in patients with ischemic heart disease. The frequent finding, however, of a short common left trunk and/or a left coronary prevalence in patients with aortic lesions is stressed under diagnostic and therapeutic viewpoints.

Adult↗
PubMed1980

[Angiographic mitral regurgitation in patients with chronic ischemic cardiopathy. Coronarioangiographic and ventriculographic correlations (author's transl)].

Mitral regurgitation in patients with chronic ischemic cardiopathy may occur following dysfunction of the papillary muscles and left ventricular impairment. A total of 291 patients with significant coronary lesions and absence of associated cardiopathies are reviewed. Patients were divided into three groups: Group A, formed by 241 cases without mitral regurgitation; group B, including 42 patients with slight mitral regurgitation, and group C, formed by eight patients with moderate or severe mitral regurgitation. Significant differences between groups A and B in relation to the number of affected coronary arteries, inferior or anterolateral akinesia-dyskinesia, and left ventricular enlargement were observed. There were no significant differences between groups B and C, though all patients of the last group had two or three affected coronary arteries. Angiographic mitral regurgitation following chronic ischemic cardiopathy is uncommon, especially moderate or severe degrees of regurgitation. Mitral regurgitation is related to the number of affected coronary arteries, presence of inferior or anterolateral akinesia-dyskinesia, and enlargement of the left ventricle. Clinical signs of significant mitral regurgitation may suggest the existence of coronary lesions, at least in two vessels.

Angiocardiography↗
PubMed1980

[Left ventricular function and state of the coronary tree in patients with significant coronary lesions (author's transl)].

The prognosis of patients with ischemic cardiopathy is mainly based upon the number of affected vesssels, the state of the distal coronary tree, and the left ventricular function. Coronary arteriographies and ventriculographies corresponding to 274 consecutive patients (January, 1975-October, 1978) with significant coronary lesions are reviewed. A singles vessel obstruction was registered in 36.5 percent of the patients; obstruction of two vessels was present in 28.5 percent, and of three vessels in 29.9 percent. The common left trunk was obstructed in 5.1 percent of the cases. The anterior descending coronary artery was affected in 78 percent of the patients, and the left coronary artery, circumflex, first marginal branch, and first diagonal branch showed narrowing in 62, 34, 36, and 26 percent, respectively. The distal tree of the above mentioned arteries was appropriate for coronary bypass operations in 51, 49, 50, 38, and 10 percent of the arteries, respectively. On the basis of coronary angiographic and ventriculographic criteria 117 patients (43 percent) were not candidates to coronary bypass surgery. The ejection fraction was less than 0.40 in 22 percent of the cases, and below to 0.30 in 12 percent (34 patients). The outstanding finding in the present series was the impairment of the distal coronary tree due to advanced atherosclerosis.

Adult↗