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Biomedical subjects

F Jakab

Publications and source records attributed to F Jakab.

At least 55 records · Page 3Linked to original sources
PubMed1990

The role of Ca2+ level in liver transplantation.

During orthotopic liver transplantation Ca2+ assessment was made in the recirculation phase and the ultrastructural changes in the liver were studied. It was established that the Ca2+ level decreased progressively. The Ca2+ level in the hepatic vein was lower than the arterial value. The EM studies performed in the recirculation phase did not reveal any cellular damage, only the swelling of the mitochondria was striking. Based on the results, the question was raised whether Ca2+ can have a prognostic role in assessing the viability of the liver.

Animals↗
PubMed1990

Prognostic factors and treatment tactics in the surgery of liver abscesses.

The prognostic factors of 21 patients with pyogenic liver abscess were analyzed. It was stated that survival is unfavourably influenced by hyperbilirubinaemia, the mixed bacterial population, the associated diseases as well as the tumorous process. As a result of portal antibiotic perfusion, there was no difference in the mortality rates of multiple and solitary liver abscesses. Based on the analysis of the prognostic factors, the surgical tactics is developed, i.e. a need for surgical exposure is supported, which imposes three tasks: exposure of the abscess/es, management of the primary process inducing the abscess and introduction of a cannula for portal antibiotic perfusion. Besides some criteria, although the author do not have experience in this field, they suggest the use of percutaneous drainage controlled by echography or CT, basically because of the lower mortality rate.

Aged↗
PubMed1989

Management and care of the precanceroses of the stomach in the 11-year material of our clinic.

The present paper surveys over the past 11 years the cases of the endoscopic laboratory of our clinic which, according to criteria accepted all over the world, were considered as precancerous states of the stomach. According to the authors' experience, an advance in the management of malignant diseases can only be expected by referring to operation the cases in their early stage, if the examination and regular control of the patients are carried out with the predisposing factors being considered by a team involving the surgeon, endoscopist and pathologist.

Adenocarcinoma↗
PubMed1988

Postoperative pancreatitis after biliary and gastric operations.

Based on review of the literature and on their own material, authors have established that pancreatitis, following biliary and gastric operations, develops mostly at interventions performed on the papilla of Vater and/or around its region. The characteristic signs of the early postoperative. (2nd-4th day) pancreatitis are essentially confined to the pancreas (i.e. necrosis, abscess, erosion, bleeding, fistula). The time of early surgical intervention and the type of solution vary by patients. Recognition of the spreading of autolysis is possible by sonographic or computer tomographic control which also help in diagnosing further complications and indicating additional operations. Prognosis is poor and lethality is high and, consequently, the gastric or biliary operations involving the papilla of Vater or its region should be performed with particular caution. Postoperative pancreatitis can be a specific risk-factor of these operations.

Biliary Tract Surgical Procedures↗
PubMed1988

Echinococcus alveolaris treated by right trisegmentectomy.

A case of Echinococcus alveolaris of the liver treated by right trisegmentectomy is reported. The imaging procedures (sonography, CT, angiography) ensuring preoperative diagnosis were of help in performing of resections and they can also be used in the postoperative follow-up.

Echinococcosis, Hepatic↗
PubMed1988

Gastric stump carcinoma.

In the periods between 1960 to 1973 and 1974 to 1984, 10 patients with stump carcinoma were observed for a total of 1399 and 618 gastric resections, respectively. Although the member of stump carcinomas is relatively low, it can be stated that the patients undergoing resection for gastric ulcer are more at risk in facing the development of stump cancer. It is striking that, even despite an improvement in diagnostic procedures, resectability has not changed. The prognosis of survival may afford some hope only in the case of an early diagnosis. Consequently, it is advisable to make an annual endoscopic control in the patients more at risk for having been resected for gastric ulcer.

Female↗
PubMed1988

Changes in heparin level in experimental liver transplantation in dog.

Changes in heparin level during orthotopic liver transplantation were studied in experiments without the administration of heparin in dogs. It was established that the changes in heparin level might probably not play a role in giving rise to coagulopathy observed during liver transplantation. Their data also indicated that the rise in heparin level had originated not from the re-perfused liver but from the release of endogenous heparin.

Animals↗
PubMed1987

Examination of lymph and bile composition following experimental liver transplantation in rat.

The lymph flow of the thoracic duct, the protein content of the lymph, bile flow and bile composition are studied during the first three hours of the recirculation phase in experimental liver transplantation. It is established that the lymph flow and the protein content of the thoracic duct decrease as a result of the interruption of hepatic lymph flow of a high protein concentration. The change in bile composition and flow is due to the reduced bile acid excretion of the transplanted hepatic tissue.

Animals↗
PubMed1987

Changes in bile and lymph composition following portacaval anastomosis (PCA) in rat.

The effect of PCA on bile and lymph composition in rats was studied. It was established that secretion of bile acid decreased significantly and this resulted in reduced bile flow. In studying lymph flow and protein content, the most important observation was a decrease in the protein concentration of hepatic lymph. It can be supported that hepatic blood flow decreased due to PCA is responsible for all these changes.

Animals↗
PubMed1987

'Cuffed' portacaval anastomosis in rat.

Preparation of portacaval anastomosis (PCA) in patients suffering from portal hypertension has been an accepted procedure for reducing portal pressure. Recently, fashioning of mesocaval anastomosis has got preference. In the era of portacaval anastomoses numerous experimental works were concerned with the technique of performing them. During these experiments it was revealed that PCA produces considerable changes both in the metabolism and the circulation of the liver. Fischer et al. state that, following PCA, the weight of the liver decreased, on an average by 55%, as compared to the controls. Ossenberg et al. observed that after PCA liver perfusion was reduced by about 55-65%. Rubin et al. demonstrated that the hepatic cytochrome P 450 content was significantly decreased and the function of the microsomal drug metabolizing enzymes markedly altered subsequent to PCA. All these data indicated that, as a results of the bypassing of portal inflow from the liver, PCA significantly influences liver function and the intervention in experimental animals, i.e. rats, can be used as a model for chronic hepatic insufficiency.

Animals↗
PubMed1980

Cannulation of the cervical thoracic duct in the rat.

A method is described for cannulation of the cervical part of the thoracic duct in the rat. The volume or lymph flowing from the cervical cannula is approximately 80% higher and its protein concentration by about 18% lower than that of the lymph collected from a cannula introduced into the abdominal part of the thoracic duct.

Abdomen↗
PubMed1980

The effect of lymphostasis on bile flow and composition in the rat.

The ligation of the thoracic duct and of the hepatic lymph vessels leads in the rat to a decease of bile flow and bile salt output. Bilirublin excretion was temporarily reduced both in lymphostasis and in sham operated animals, but bilirubin concentration in the bile rose progressively and after 3 hours bilirubin output returned in both groups to the control level.

Animals↗
PubMed1978

Mucosa of the Heister valve in cholelithiasis: transmission and scanning electron microscopic study.

Light, transmission, and scanning electron microscopic studies were performed on 24 gallbladders with thin walls, without inflammation, extirpated by cholecystectomy because of gallstones and on five, free from biliary diseases, obtained by autopsies. Examination of gallbladders and epithelium covering the valvula spiralis (Heister) of the ductus cysticus showed the surface structure of the epithelium covering the Heister valve to be mulberry-like and characteristically pleated, similar to the epithelial lining of the gallbladder. In cases of cholelithiasis, several denuded areas were detectable on the valves. The epithelial lining of the gallbladder was intact. As a new observation, we describe the appearance of worm-like processes on the lateral surface of detached epithelial cells, seen during the course of scanning electron microscopic study. These probably correspond to interdigitating cell junctions observed by transmission electron microscopy.

Cholelithiasis↗
PubMed1978

Formation of cholesterol gallstones: the role of metabolic factors and of congestion.

Cholesterol gallstones were induced in mice by means of a lithogenous diet. Some of the animals were given in addition morphine regularly. The ten-week experiment was concluded with operation. Lithogenesis was recorded, the volume of the gallbladder was measured, the bile collected for analysis and a specimen was taken from the liver for histologic examination. In the animals fed the lithogenous diet were only gallstones found. The occurrence of cholestasis was unequivocally be proved by the volume of the gallbladder and the microscopic examination of the bile sediment in the group treated with morphine. Metabolic factors seem to play the primary role in the formation of cholesterol gallstones; cholestasis is of secondary importance.

Animals↗