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Biomedical subjects

F J Veith

Publications and source records attributed to F J Veith.

At least 379 records · Page 21Linked to original sources
PubMed1976

131I-fibrinogen in the detection of pulmonary allograft rejection.

The uptake of 131I-fibrinogen in canine pulmonary allografts was compared to that in lung autografts or lungs with papain-induced unilateral hemorrhagic pneumonia. In addition to serial lung scans and the postmortem measurement of tissue radioactivity, all dogs had serial chest roentgenograms and histologic study of their lungs. All four animals in the allografted group had increased radioactive uptake on the side of the allograft lung at the same time as or slightly before radiographic abnormalities were evident. However, increases in lung radioactivity also occurred in animals with pneumonia or autografts at the time infiltrates were present. Thus the presence of increased lung scan activity, which occurs in rejecting lung allografts after the injection of 131I-fibrinogen, is not a specific index of pulmonary rejection.

Animals↗
PubMed1976

Intravenous rupture of arteriosclerotic aneurysms of the abdominal aorta.

Intravenous rupture of abdominal aortic aneurysms occurs infrequently but should be considered with the coexistence of severe congestive failure, anasarca, and abdominal bruits. Six patients are presented with four survivors. In only two patients was the diagnosis considered preoperatively without angiography. Two were variants in that thrombus occluded the fistula, thereby negating findings usually manifested clinically. Diagnosis of this type can be made only during operation when copious venous bleeding ensues with evacuation of the aortic thrombus. Careful fluid management and prompt surgery are prerequisites to obtaining a successful outcome. Repair is accomplished easily by suturing the fistula from the aortic aspect, but care is required to avoid dislodgement of thrombus and atherosclerotic debris resulting in pulmonary embolism.

Aged↗
PubMed1975

Effect of ureteral stent on urinary tract infections in renal transplantation.

A retrospective study was carried out to determine the effect of ureteral intubation during renal transplantation. We noted urinary tract infections in 76 per cent of those patients whose ureters were intubated during transplantation, as opposed to 45 per cent in those transplant recipients without ureteral stents. The incidence of recurrent urinary tract infections also increased from 18 to 34 per cent with the use of ureteral catheters. Ten separate episodes of bacteremia, indirectly related to indwelling catheters, are noted.

Adolescent↗
PubMed1975

Pathologic pulmonary changes in hemorrhagic shock.

Fifty-seven dogs were subjected to hemorrhagic hypotension by a variety of protocols. Histologic pulmonary changes were studied using the light microscope. Of these 57 dogs, 21 had no demonstrable lesions, 8 had minimal changes, and 28 had moderate or severe lesions, all of a focal nature. No correlation was found between the presence of lesions and mean systemic arterial pressure during shock, the udration of the hemorrhagic period, the fate of the animal, preoperative hematocrits and blood volumes, mean postreinfusion arterial pressure, whether the animals were mongrels or purebred beagles, whether they were awake or sedated, whether they breathed spontaneously or were artifically ventilated, whether they had undergone previous splenectomy or not, whether hilar stripping was performed or not, and finally, whether blood was reinfused after hemorrhage or not. Thus we conclude that multiple factors may exert a harmful effect on the lung in hemorrhagic shock, and that shock probably makes the lungs more vulnerable to other injurious agents rather than there being one single pathogenetic mechanism for the pulmonary damage. The term "adult respiratory distress syndrome" rather than "shock lung" is best used for the human clinical entity since it implies a complex ettiology rather than a discrete pulmonary lesion produced by a single pathogenetic mechanism.

Animals↗
PubMed1975

Intimal injury and regrowth in the rabbit aorta; medial smooth muscle cells as a source of neointima.

The present study was undertaken to determine the mechanism of neointima formation in rabbit arteries subjected to extensive endothelial desquamation. Endothelial cells were selectively removed from the abdominal aorta by passing an inflated balloon catheter through the vessel. The healing response was then studied serially for up to a week, when neointima formation had provided a virtually complete cover. In en face preparations, the early neointimal cells appeared in random locations; they did not develop in apposition to residual, healthy endothelium. The possibility of blood cell colonization was explored by inserting killed aortic homografts. Since these homografts showed neointima formation only close to the site of junction with the normal aorta and as a direct extension of healthy endothelium, the likelihood of significant blood cell colonization was deemed small. Histologic and electron microscopic sections provided evidence that the early neointimal cells in the healing aorta were derived from medial smooth muscle cells. Healing of the injured arterial intima was accompanied by thickening instead of prompt restoration to normal, and the thickened intima resembled an arteriosclerotic plaque. The present study thus supports the concept that arteriosclerosis is a disease involving proliferation of medial smooth muscle cells.

Animals↗
PubMed1975

Corticosteroids in clinical and experimental lung transplantation.

Lung allograft rejection can usually be diagnosed by the appearance of infiltrates on plain chest roentgenograms when these are interpreted in the light of other clinical and bacteriologic information. Large pulsed intravenous doses of methylprednisolone were usually effective in reversing lung allograft rejection that occurred in immunosuppressed dogs. In 10 of 15 animals the presence of moderate to severe rejection and its effective reversal with treatment were documented with roentgenograms and histologic sections. This ability to reverse the manifestations of lung allograft rejection, when they occur, has helped in the management of human lung allograft recipients.

Animals↗
PubMed1975

Patient selection and improved technical factors in small-vessel bypass procedures of the lower extremity.

Thirty-two small-vessel bypasses were constructed as limb-salvage procedures. The one month patency rate was 72 percent and the one year cumulative patency rate was 55 percent. Preoperative, intraoperative, and postoperative angiography was performed in most cases and the results correlated with the ultimate fate of the graft. Preoperative angiography is critical in determining the location of a suitable small vessel, including the peroneal artery, and the quality of the runoff. Intraoperative angiography is required to delineate correctable intraoperative defects usually appearing at the distal anastomotic area. Additionally, failure to demonstrate runoff or a pedal arch can help support a decision not to re-explore a graft should early closure occur. Postoperative angiography is essential to validate clinical success with graft patency and function. It also serves to discover potential graft defects that might otherwise lead to closure and potential limb loss. Selected cases of failed small-vessel bypass grafts may be salvaged by thrombectomy with or without graft revision. Small-vessel bypass is generally contraindicated if there is extensive tissue necrosis and infection extending into the proximal foot. In cases where the necrotizing infection is localized, particularly to the forefoot, then open drainage, debridement, or amputation should be performed together with small-vessel bypass. Finally, the risks indigenous to small-vessel bypass procedures demand optimal patient selection and exquisite operative technique.

Amputation, Surgical↗
PubMed1975

Alveolar lavage cytology in transplanted lungs. I. Staining methods and findings in dogs with autografts and allografts without immunosuppression.

Alveolar lavages were performed repetitively on the normal and transplanted lungs of dogs that had recieved autografts or allografts without immunosuppression. One half of the lavage returns was fixed as a cytologic smear; the other half was subjected to semi-thin section or electron microscopic examination. Of the staining methods was used, the periodic acid-Schiff (PAS) and Giemsa techniques were best for differentiating and counting cells. The Ladewig technique was best for evaluating the presence and location of fibrin. After autotransplantation, the proportion of so-called alveolar marcophages increased, reached a peak in 4 to 7 days, and then returned to normal. Phagocytized fibrin increased for the first postoperative week, but not extracellular fibrin was ever observed. After allotransplantation, a progressive decrease in the proportion, size, and vacuolization of so-called alveolar macrophages was noted along with an increase in extracellular fibrin. Intracellular fibrin could be detected only up to the third day. These findings define adequate methods for preparing and staining material obtained from diagnostic alveolar lavages, and they suggest that the procedure may serve as an index of lung allograft rejection.

Animals↗
PubMed1974

Arterial reconstruction with a modified collagen tube: a clinical experience.

Twenty-one modified bovine grafts were implanted in a variety of arterial reconstructions. Successful clinical results were obtained in 60% of the survivors. Attention is directed, however, to the problems of difficulty in reexplorations, the lack of elasticity, and aneurysm development indigenous to the bovine graft. One infection in this series required graft removal and extra-anatomic bypass. The modified bovine graft represents a major advance in vascular reconstruction, but should not be accepted as the ideal arterial prosthesis.

Aneurysm↗