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Biomedical subjects

F J Veith

Publications and source records attributed to F J Veith.

At least 343 records · Page 19Linked to original sources
PubMed1979

Expanded polytetrafluoroethylene graft fistula for chronic hemodialysis.

In a retrospective study of 66 PTFE arteriovenous fistulae and 71 BCH arteriovenous fistulae for dialysis access, PTFE had a higher patency rate than BCH at 12 months (62.4 versus 32.5%). PTFE was easier to work with and easier to handle in the face of infection. The lateral upper arm approach to placement of the PTFE graft is desirable in patients who have had multiple previous access procedures because this area is usually free from scarring, is distant from neurovascular structures, and provides a greater length of graft for needle punctures.

Aneurysm↗
PubMed1979

Long-term fate of lung autografts charged with providing total pulmonary function. I. Light and electron microscopic studies.

Two groups of dogs underwent light and electron microscopic examination of both lungs up to five years after left lung autotransplantation. In one group of four dogs that had undergone ligation of the right pulmonary artery at the time of left lung autotransplantation, no generalized or consistent lesions were present in the transplant except for slight distension of net capillaries and slight capillary basement membrane thickening. Aside from theseminor changes which were probably of no functional significance, most areas of lung examined up to five years after transplantation were normal. In the second group of four dogs that did not have contralateral pulmonary artery ligation at the time of left lung autotransplantation, no consistent abnormality was present in either the transplanted left or nontransplanted right lung. In three animals in this group, widespread normal areas were present bilaterally up to five years after transplantation. One animal in this group had focal changes consistent with chronic pulmonary disease in both of its lungs. Thus, transplanted lungs do not necessarily develop significant late pathologic lesions.

Animals↗
PubMed1979

Long-term fate of lung autografts charged with providing total pulmonary function. II. Hemodynamic, functional and angiographic studies.

Four dogs underwent autotransplantation of the left lung with immediate ligation of the right pulmonary artery and survived up to five years. Mean pulmonary artery pressures increased from 15 +/- 2 mmHg preoperatively to 23 +/- 4 mmHg immediately after operation and remained at the level (24 +/- 3 mmHg) up to five years operation. Arterial and venous blood gas values, determined while the animals were breathing ambient air spontaneously under light anesthesia, did not deteriorate with time and were within the normal range. The vascular resistance of the transplanted lungs up to five years after operation were not significantly different from those determined immediately after operation and remained lower than preoperative values, indicating that transplanted lungs retain indefinitely the ability to vasodilate with increased blood flow. Periodic angiography performed from 3-5 years after operation confirmed that the right lungs received no pulmonary blood flow and revealed normal vascular morphology except for moderate dilatation of the large arteries in the transplanted left lung. Thus, single transplanted lungs can provide total respiratory function while carrying the entire pulmonary blood flow at tolerable arterial pressures for at least five years without evidence of functional deterioration.

Angiography↗
PubMed1979

Effect of donor bronchial length on healing: a canine model to evaluate bronchial anastomotic problems in lung transplantation.

Bronchial anastomotic complications in lung transplantation in man remain a major cause of failure. To study this problem in a canine model, we varied the length of the distal bronchial component in three groups of dogs that underwent hilar stripping, bronchial transection, and reanastomosis, The distal bronchial component was thus analogous to the donor in a transplanted lung. Anastomoses were performed, respectively, at the level of the main carina (long single anastomosis), at the midpoint between the main carina and the bifurcation of the left main-stem bronchus (short single anastomosis), and just distal to the bifurcation of the left main-stem bronchus (lobar anastomosis). Bronchial anastomotic damage and necrosis were evaluated by periodic examination with a fiberoptic bronchoscope and by gross and microscopic examination at sacrifice on the seventh postoperative day. The long single anastomoses demonstrated the most necrosis, and the labor anastomoses showed the least. The short single anastomoses showed an intermediate degree of damage. These findings support the hypothesis that shortening the distal or donor bronchial component reduces anastomotic damage, probably because of better pulmonary-to-bronchial collateral blood supply. This study provides a canine model by which to examine bronchial anastomotic complicatons and demonstrates the feasibility of performing labor anastomoses as a means for decreasing bronchial anastomotic problems in lung transplantation.

Animals↗
PubMed1979

Differential lung blood flows in experimental unilateral emphysema: nonvalidity of perfusion scans.

As part of an evaluation of the effects of left lung transplantation in dogs with papain emphysema of the right lung, differential lung blood flows were estimated by in vivo scintiscan of 99Mc-macroaggregated albumin (99mTc-MAA) and, after sacrifice, by direct counting of isotopically labeled carbonized microspheres. In six dogs, percentage flow to the right lung was calculated at the following four times: before and after induction of papain emphysema and 2 and 6 weeks after left lung autotransplantation. After the induction of right lung emphysema, the right lung in four of six animals continued to receive more than 50 percent of the total pulmonary blood flow. No correlation could be established between right lung blood flow determined by carbonized microsphere distribution (true right lung blood flow) and the flow determined by anterior and posterior scintiscans (apparent right lung blood flow). This discrepancy was caused by gross distortion of the right, emphysematous lungs, which had herniated into the left hemithoraces. This herniation was demonstrated by coronal slices taken through the thoraces of two additional dogs with right lung emphysema that were given radiolabeled carbonized microspheres and 99Tc-MAA and frozen after sacrifice. These results indicate that external scintiscans for which the particulate distribution technique are used are invalid in circumstances of altered lung geometry.

Albumins↗
PubMed1979

Preoperative saphenous venography in arterial reconstructive surgery of the lower extremity.

Preoperative saphenous venography was performed in 100 extremities in 60 patients to evaluate the saphenous vein for use as an arterial bypass graft. In 18 of the patients (30%), venography demonstrated vein abnormality, disease, or small size, which significantly influenced the management of the patient or the conduct of the operation. Good correlation was observed between venographically determined saphenous vein anatomy and diameter and those observed at operation in 52 patients. The average diameter of the saphenous veins on preoperative venograms was 3.4 mm (range, 1.0 to 6.0 mm). These veins dilated to an average diameter 73 +/- 5% greater than that observed venographically, so that the average diameter of harvested, dilated saphenous veins was 5.5 mm (range, 3.0 to 10.0 mm). All veins measuring 2.0 mm or more on the venograms dilated to 4.0 mm or more at operation and were suitable for femoropopliteal or small vessel bypass grafts. Four saphenous veins measuring 1.0 mm or more on the venograms dilated to 3.0 mm or more at operation and were suitable for small vessel bypasses. Thus preoperative saphenous venography can be of value in lower extremity arterial reconstructions. The procedure allows detection of anomalies and disease processes that would prevent the use of one or both saphenous veins as arterial bypass grafts and identifies the best available venous segment thereby obviating unnecessary incisions and minimizing operating time.

Arterial Occlusive Diseases↗
PubMed1978

Expanded polytetrafluoroethylene grafts in reconstructive arterial surgery. Preliminary report of the first 110 consecutive cases for limb salvage.

One hundred ten arterial reconstructions, including several new and extended bypasses, were performed with polytetrafluoroethylene (PTFE) grafts and were observed for three to 16 months. Patency rates were 100% with 15 bypasses to the femoral artery, 95% with 66 bypasses to the popliteal artery, and 76% with 29 bypasses to the arteries of the leg and foot. These encouraging preliminary results justify continued use and evaluation of PTFE as an arterial prosthesis.

Arteries↗
PubMed1978

Anti-lung antibodies associated with human lung allografts.

Serum specimens from 4 patients who had had a lung allograft were examined for anti-lung antibodies. Two patients developed antibodies after transplantation, and in 2, the antibodies increased in titer after an allograft. The absorption of the anti-lung antibody by fetal lung cell cultures, in contrast to the failure of absorption by kidney cell cultures from the same fetus, indicates that the antibody is lung specific.

Antibody Specificity↗
PubMed1978

Transplantation of the left lung into the right hemithorax to facilitate immediate reconstitution of bronchial artery flow.

Immediate bronchial artery reconstitution may be important in the prevention of bronchial anastomotic problems in lung transplantation. To facilitate this reconstitution in circumstances requiring allograft replacement of the right lung, we developed a method for transplanting the left lung together with its bronchial arterial supply into the right hemithorax. With this method, left lungs were allotransplanted into the right hemithorax of nine immunosuppressed dogs. Six recipients survived 1 to 4 weeks. Death resulted from pneumonia or rejection, and there were no bronchial anastomotic problems. Roentgenograms showed that the bronchial artery was patent and that the inverted transplanted left lungs could conform exactly to the thorax without space problems or radiographic abnormalities. Except for the unusual position of the large pulmonary arteries, angiographic patterns, function, and perfusion of the transplanted lungs were often normal and equivalent to those of the recipient's normal left lung. Thus it is possible to transplant a left lung into either hemithorax and immediately reconstitute its bronchial arterial circulation. Bronchial anastomotic problems may thereby be decreased.

Animals↗
PubMed1978

Transplantation of children's kidneys into adult recipients.

In the present study of 31 kidneys transplanted from donors ranging in age from one to one-half to nine years, the ability of kidneys from donors in the pediatric age group to provide adequate renal function in adults is evaluated. Kidney function was reviewed six months, one year, three years and five years after transplantation. Forty per cent of the transplanted kidneys from this age group had excellent function at six months. Of the kidneys at risk for five years, 30 per cent were still functioning. Kidneys from donors three years of age and younger developed a creatinine clearance rate of 20 milliliters per minute in 12 days or less. Maximum creatinine clearance rates for kidneys from donors of the pediatric age group equaled those of adult donors. In addition, recipients of pediatric kidneys after one year tended to maintain a lower creatinine level than did their counterparts receiving adult kidneys. Thus, kidneys from donors as young as 18 months of age can be transplanted individually without special difficulties and can be expected to provide excellent renal function for adult recipients.

Adult↗