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Biomedical subjects

F J Stanley

Publications and source records attributed to F J Stanley.

At least 55 records · Page 3Linked to original sources
PubMed1994

A matched cohort study of planned home and hospital births in Western Australia 1981-1987.

OBJECTIVE: to evaluate practice comparing planned home birth with planned hospital birth DESIGN: a retrospective analysis of a cohort who had planned to have a home birth compared with a matched hospital birth group SETTING: Western Australia (WA) PARTICIPANTS: all women (N = 976) who 'booked' to have a home birth 1981-1987 and 2928 matched women who had a planned hospital birth (singleton births only). MEASUREMENTS AND FINDINGS: women in the home birth group had a longer labour, were less likely to have had labour induced or to have had any sort of operative delivery. They were less likely overall to have had complications of labour, but more likely to have had a postpartum haemorrhage and more likely to have had a retained placenta. Babies in the home birth group were heavier and more likely to be post-term. They were less likely to have had an Apgar score below 8 at 5 minutes, to have taken more than 1 minute to establish respiration or to have received resuscitation. The crude odds ratio for planned home births for perinatal mortality was 1.25 (95% CI 0.44-3.55). Postneonatal mortality was more common in the hospital group. Planned home births were generally associated with less intervention than hospital births and with less maternal and neonatal morbidity, with the exception of third stage complications. Although not significant, the increase in perinatal mortality has been observed in other Australian studies of home births and requires continuing evaluation. KEY CONCLUSIONS: Planned home births in WA appear to be associated with less overall maternal and neonatal morbidity and less intervention than hospital births. IMPLICATIONS FOR PRACTICE: whether these observed differences in intervention and morbidity have any relationship to the small, non-significant increase in perinatal mortality could not be determined in this study. Continuing evaluation of home birth practice and outcome is essential.

Cohort Studies↗
PubMed1994

The aetiology of cerebral palsy.

I have attempted to give an overview of the latest thoughts on the aetiology of the cerebral palsies. These motor disabilities are of continuing interest and their prevalence is rising, particularly in low birth weight preterm singletons and multiple births. The likely multiplicity of causes demands intelligent investigation probably in collaborative population data bases. Ultrasound and other scans may provide better data on both site and timing of neonatal brain damage. However these are more likely to have been done on cerebral palsied children who were preterm than on those born at term. There are currently no clear preventive messages except those relating to postnatal cerebral palsy or encouraging strategies to reverse the increases in multiple births. The challenges now are to obtain better data on the antenatal factors and on causal sequences which may be important. The Little Foundation is seeking to encourage such collaborative studies. Other suggestions from our workshop [14] included attempting to follow up those infants who have been participants in large randomised controlled trials (such as those evaluating surfactant) to the age when they can be confidently diagnosed as having cerebral palsy. If antenatal data have been collected on them they may form the basis for a cohort analysis relating risk to cerebral palsy occurrence, as well as to answer questions about whether the intervention influenced cerebral palsy occurrence.

Asphyxia Neonatorum↗
PubMed1994

A population database for maternal and child health research in Western Australia using record linkage.

This paper describes a linked total population database established in Western Australia for monitoring and evaluating maternal and child health and for conducting epidemiological studies. Good vital statistics data including all Western Australian hospitalisations and excellent birth defects and cerebral palsy registers have ensured that complete data are available. Examples of studies which have been conducted using the database are given.

Case-Control Studies↗
PubMed1994

Sudden infant death syndrome in aboriginal and non-aboriginal infants.

This study, based on routinely recorded data, was designed to compare the epidemiology of sudden infant death syndrome (SIDS) in Aboriginal and non-Aboriginal infants in Western Australia (WA). All cases of SIDS occurring in infants born in WA from 1980 to 1988 were included in the study. There were 66 Aboriginal (6.1 per 1000 live births) and 337 non-Aboriginal (1.7 per 1000 live births) infants who died from SIDS. It was found that there was a significant linear increase in the Aboriginal SIDS rate over the study period while the non-Aboriginal rate remained relatively constant. For non-Aboriginal infants, there was an elevated risk of SIDS for young maternal age, single marital status and male gender but this was not found for Aboriginal infants. There was a significant difference in the age at death distribution for the two populations. Low birthweight and preterm birth were risk factors for both Aboriginal and non-Aboriginal infants. There may be differences in the aetiology and/or classification of SIDS between the two populations.

Age Distribution↗
PubMed1994

Sudden infant death syndrome and infant mortality in aboriginal and non-aboriginal infants.

The aim of this study was to investigate sudden infant death syndrome (SIDS) in the context of total infant mortality for Aboriginal and non-Aboriginal infants. Deaths for infants born in Western Australia from 1980 to 1988 inclusive were ascertained from a total population data base. Infant mortality rates and rates by period and cause of death were calculated for both populations. Aboriginal infants had a mortality rate three times that for non-Aboriginal infants (23.6 cf. 7.9 per 1000 live births) and both populations showed a similar rate of decline in mortality over the study period. There were differences in the proportion of deaths occurring neonatally and postneonatally in the two populations. In terms of SIDS, 21% of the deaths in Aboriginal infants occurred neonatally compared with 7% for non-Aboriginal infants. The overall cause of infant death distribution differed significantly between the two populations (P < 0.001). During the study period, Aboriginal infants showed a significant increase in deaths due to SIDS and a significant decrease in those due to birth defects and low birthweight. These results suggest it would be useful to review the pathology and diagnosis of sudden unexplained death in infancy.

Cause of Death↗
PubMed1994

Hospital admissions before the age of 2 years in Western Australia.

A linked data file of birth records and hospital admissions was used to investigate inpatient hospital morbidity before 2 years of age for all non-Aboriginal and Aboriginal children born in Western Australia in 1986. Of the non-Aboriginal children, 31.8% were admitted to hospital at least once before the age of 2 years, with an overall admission rate of 526/1000 live births; the corresponding figures for Aboriginal children were 68.7% and 2797. The mean number of days in hospital for each non-Aboriginal child admitted was 7.4, and 26.5 for Aboriginal children. Of the total cohort, 21% of non-Aboriginal and 20% of Aboriginal children were admitted only once, and 4% of non-Aboriginal and 36% of Aboriginal children were admitted at least three times; 23% of non-Aboriginal and 24% of Aboriginal children were admitted for only one major disease category, and 1% of non-Aboriginal and 16% of Aboriginal children were in at least four categories. The highest admission rates and highest percentages of the cohort admitted were for gastrointestinal and respiratory diseases and social admissions. These results illustrate the importance for both descriptive and analytical research of relating admissions to hospital for the total population to the individual child, and of using clinically relevant disease classifications.

Cohort Studies↗
PubMed1994

Cesarean section and operative vaginal delivery in low-risk primiparous women, Western Australia.

OBJECTIVES: A major component of the increasing trend in cesarean sections in Western Australia is the rise in emergency cesarean sections in primiparous women. The aim of this study was to identify independent risk factors (particularly those known early in pregnancy) associated with operative delivery in low-risk primiparous women. METHODS: Retrospective multivariate logistic regression analyses of antenatal and perinatal data were conducted for all low-risk primiparous women entering labor spontaneously and giving birth in Western Australia in 1987 (n = 3641). RESULTS: Of the subjects, 58% had a spontaneous vaginal delivery, 8% had an emergency cesarean section, and 34% had an operative vaginal delivery. The significant independent risk factors for emergency cesarean section were older maternal age, shorter maternal height, heavier infant birthweight, and long labor. The risk factors for operative vaginal delivery were older maternal age, shorter maternal height, heavier infant birthweight, epidural anesthesia, labor/delivery complications, male infant, private patient status, and being married. CONCLUSIONS: This multivariate analysis confirms known risk factors for operative delivery in low-risk primiparous women and suggests that it may be possible to predict the likelihood of operative delivery for an individual woman by using knowledge of maternal age and height and assessment of infant birthweight.

Adult↗
PubMed1993

Effects of frequent ultrasound during pregnancy: a randomised controlled trial.

Despite widespread application of ultrasound imaging and Doppler blood flow studies, the effects of their frequent and repeated use in pregnancy have not been evaluated in controlled trials. From 2834 women with single pregnancies at 16-20 weeks gestation, 1415 were selected at random to receive ultrasound imaging and continuous-wave Doppler flow studies at 18, 24, 28, 34, and 38 weeks gestation (the intensive group) and 1419 to receive single ultrasound imaging at 18 weeks (the regular group). Outcome data was obtained from 99% of women who entered the study. The only difference between the two groups was significantly higher intrauterine growth restriction in the intensive group, when expressed both as birthweight < 10th centile (relative risk 1.35; 95% confidence interval 1.09 to 1.67; p = 0.006) and birthweight < 3rd centile (relative risk 1.65; 95% confidence intervals 1.09 to 2.49; p = 0.020). While it is possible that this finding was a chance effect, it is also plausible that frequent exposure to ultrasound may have influenced fetal growth. Repeated prenatal ultrasound imaging and Doppler flow examinations should be restricted to those women to whom the information is likely to be of clinical benefit.

Adult↗
PubMed1993

Absorption of pteroylpolyglutamates in mothers of infants with neural tube defects.

The ability to hydrolyse and absorb pteroylpolyglutamates (PteGlun) included in a standard meal in mothers who had given birth to an infant with a neural tube defect was tested by comparing them with mothers who had not had any infants with this defect. When compared with control mothers working in the research unit in which the study was performed, case mothers had significantly lower baseline serum and erythrocyte folate levels, and smaller increases in serum folate following the meal containing PteGlun. However, all estimates of folate were similar when case mothers were compared with a group of mothers who were friends of the case mothers. The results show that the higher the baseline levels of serum and erythrocyte folate the greater the increase in serum folate after the test meal. Fitting a model for the serum folate response curve resulted in coefficients which differed significantly between case mothers and all control mothers. We conclude that intestinal hydrolysis of PteGlun taken orally is not impaired in mothers who have had infants with neural tube defects when compared with control mothers with similar baseline folate levels, although the curves describing the response to the meal for the two groups do differ significantly. Further investigation is required to determine the mechanism underlying this difference.

Adult↗
PubMed1993

Small-for-gestational-age term birth: the contribution of socio-economic, behavioural and biological factors to recurrence.

This paper follows a previous study comparing women who had repeatedly given birth to small-for-gestational-age (SGA) term infants ('repeater' mothers) with multiparous women who had had only one such infant ('non-repeater' mothers). The present investigation involves the individual matching of each woman in the above groups with a control mother whose offspring were all term non-SGA infants. The study was based on all Western Australian Caucasian women giving birth to singletons and the study population comprised 594 repeater cases with 594 matched controls and 935 non-repeater cases with 935 matched controls. Conditional logistic regression analyses indicated that demographic and paternal factors were significant predictors for recurrent SGA term birth whereas obstetric conditions, particularly preeclampsia, were important for the prediction of isolated SGA term birth. Maternal smoking, low maternal birthweight and lack of higher educational qualifications were associated with both types of SGA birth. After multivariable analyses, a strong and significant association remained between having a first infant as a teenager and recurrent SGA term birth. The tendency to repeat SGA term birth appears to be associated with social, economic and behavioural disadvantage and is unlikely to be ameliorated without fundamental changes in society.

Adolescent↗
PubMed1993

Stillbirths, neonatal and post-neonatal mortality by race, birthweight and gestational age.

The birthweight and gestational age specific mortality of singleton Aboriginal and White infants born in Western Australia during the period 1980-86 is described. The analyses are based on the approximately 8000 Aboriginal and 143,000 White births notified through the Western Australia Midwives' system, which were linked to perinatal and infant death records. Overall, stillbirth, neonatal and post-neonatal mortality risks were significantly higher (P < 0.01) for Aboriginals than Whites. However, for specific birthweights and gestational ages, particularly for infants of lower birthweight and shorter gestations, Aboriginals had lower mortality risks than Whites. The ratio of Aboriginal to White mortality risks tended to increase with advancing age of death, suggesting that longer exposure to the well-documented poorer social and environmental conditions of Aboriginal infants increased the mortality risk.

Birth Weight↗
PubMed1993

Spastic quadriplegia in Western Australia: a genetic epidemiological study. I: Case population and perinatal risk factors.

In a case-control study of all cerebral palsy cases with moderate and severe spastic quadriplegia born between 1976 and 1985, males comprised three-quarters of the cases and tended to have more severe motor impairment than females. The majority of cases had multiple and severe disabilities, and 27 per cent had died by the time of data collection. There was an excess of low-birthweight and preterm births compared with all live births in WA. An intrapartum cause was considered possible in 18 of the 74 children; however, half of these had evidence of compromise before labour.

Australia↗
PubMed1993

Spastic quadriplegia in Western Australia. II: Pedigrees and family patterns of birthweight and gestational age.

Pedigrees were obtained for all 74 index children and for three controls for each case. Recurrence of similar spastic quadriplegic phenotypes occurred in two families. A karyotype of 46,XY,dup(13)(q14q34), resulting in a partial trisomy 13, was found in another case. Rates of miscarriages and stillbirths plus neonatal deaths were higher among siblings of index cases than in siblings of birth-year controls, but were similar to siblings of birthweight controls. Average birthweights and gestational ages were lower in index cases than in birth-year controls. Children with spastic quadriplegia had significantly lower birthweights and gestational ages than their siblings. However, they also tended to come from families with a pattern of low birthweight and preterm delivery. The differences between families remained after controlling for factors affecting birthweight.

Australia↗
PubMed1992

Dietary folate and nonneural midline birth defects: no evidence of an association from a case-control study in Western Australia.

In a population-based case-control study of dietary folate and neural tube defects, information was collected by interview and self-administered questionnaires from the mothers of cases with only neural tube defects, from the mothers of matched control infants with defects other than neural tube defects, and from the mothers of matched live-born infants with no birth defects. The association of midline birth defects (excluding neural tube defects) with dietary folate intake in the first 6 weeks of pregnancy was assessed by restricting the analysis to the 59 mothers of infants with midline defects in the first control group and comparing them with their matched control infants in the second control group. The crude and adjusted odds ratios for dietary folate and for folic acid supplementation were close to one, and all confidence intervals embraced unity. These data do not provide evidence of an association between midline birth defects (excluding neural tube defects) and either dietary folate or folic acid supplementation.

Australia↗