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Biomedical subjects

F J Epstein

Publications and source records attributed to F J Epstein.

At least 73 records · Page 4Linked to original sources
PubMed1992

Adult intramedullary astrocytomas of the spinal cord.

In this series, 25 adult patients with intramedullary astrocytomas were treated by radical excision alone. Six patients proved to have anaplastic astrocytoma; five of them died within approximately 2 years and the sixth has demonstrated disease progression. The other 19 patients were diagnosed as having low-grade astrocytoma (16 cases) or ganglioglioma (three cases); two of these had advanced preoperative neurological disability and died of medical complications. Fifteen of the remaining 17 patients have no clinical evidence of tumor recurrence after a mean follow-up period of 50.2 months; the other two have a small residual neoplasm that demonstrates no progression. Of these 17 patients, seven had previously received radiation therapy, but had clear evidence of tumor growth subsequently. This experience suggests that surgery is not beneficial for anaplastic spinal astrocytoma. However, in cases of low-grade tumor, radical excision is associated with minimal morbidity and an excellent long-term prognosis when carried out before significant disability occurs.

Adolescent↗
PubMed1992

Complications of ventriculoperitoneal shunt procedures or hydrocephalus associated with vein of Galen malformations in childhood.

Twenty children with vein of Galen malformations and hydrocephalus required a ventriculoperitoneal shunt. Shunt placement was associated with a 70% incidence of complications that included status epilepticus in 3 patients, intraventricular hemorrhage in 7 patients, and subdural hematoma or hygroma in 5 patients. Based upon this experience, the authors recommend the use of preoperative prophylactic anticonvulsants and the placement of medium pressure frontal ventriculoperitoneal shunts. This report will address the overall experience with and the basis on which these therapeutic recommendations were made.

Adolescent↗
PubMed1991

Chronic headache associated with a functioning shunt: usefulness of pressure monitoring.

Chronic headaches in a shunt-dependent patient with small ventricles has long been treated with little or no regard to intracranial pressure. In this study, pressure monitoring on 12 such patients demonstrated that they fell into three distinct categories: 3 had headaches caused by intracranial hypertension, 2 had headaches from hypotension, and 7 showed no relation of symptoms to pressure. As therapeutic procedures for treating these three categories are entirely different and sometimes opposing, it is clear that intracranial pressure monitoring is essential to successful management of this complaint.

Adolescent↗
PubMed1991

Current trends in the management of brainstem tumors in childhood.

Historically, the prognosis for a child diagnosed with a brainstem tumor has been bleak. The development of magnetic resonance imaging (MRI) has allowed for detailed visualization of tumors within the brainstem. This knowledge combined with the clinical history and neurological examination allows subcategorization of such tumors and delineation of children who might benefit from surgery. Surgical candidates include children with long clinical histories, focal neurological deficits and focal, cystic, exophytic or cervico-medullary tumors on the MRI scan. All children have the potential for multiple cranial nerve abnormalities, extremity weakness and swallowing and breathing difficulties. Nursing care of patients with brainstem tumors is complex and challenging.

Astrocytoma↗
PubMed1991

Brain and spinal cord hemorrhage in long-term survivors of malignant pediatric brain tumors: a possible late effect of therapy.

Three children with malignant primary CNS tumors treated with craniospinal radiotherapy developed intraparenchymal hemorrhages a median of 5 years following therapy in sites distant from the primary tumor. Radical surgical procedures disclosed fresh and old hematoma, gliosis, and necrosis in all 3 patients and an aggregation of abnormal microscopic blood vessels in two. No tumor was found. All 3 patients remain in long-term (greater than 10 years) continuous remission.

Adolescent↗
PubMed1991

Optimal wound closure after tethered cord correction. Technical note.

A technique of wound closure following tethered cord correction is presented that significantly reduces the incidence of cerebrospinal fluid collections in the subcutaneous space. In over 60 cases, the described method of fascia and skin closure has lessened wound problems to a minimal level. Patient hospitalization time has also been greatly diminished.

Cauda Equina↗
PubMed1991

Intraoperative ultrasonography: an important surgical adjunct for intramedullary tumors.

The echographic characteristics of 186 suspected intramedullary spinal cord tumors were reviewed. Ultrasonography was found to be specific in distinguishing the tumor type, the extent of the lesion, and the presence and type of associated cysts. Ultrasonography greatly facilitates the selection of respective sites for the placement of a myelotomy, and for initiation of the resection. Additionally, this indispensable adjunct provides ongoing images that allow the preoperative plan to be precisely followed in a surgical field where anatomical landmarks are limited and the margin for error is minimal.

Astrocytoma↗
PubMed1991

Trends in surgery: laser surgery, use of the cavitron, and debulking surgery.

The purpose of this article is to expose nonneurosurgeons to high-level technological adjuncts used by pediatric neurosurgeons for the treatment of pediatric central nervous system disease. Some of the characteristics of the instruments and their most important uses are described. Emphasis is placed on the impact this technology has had in the development of "new" operations. Surgical limitations and future perspectives are also discussed.

Brain Neoplasms↗
PubMed1990

Pediatric spinal cord tumor surgery.

This article discusses our experience in managing pediatric spinal cord tumors. A description of the clinical presentation of children with such lesions and of the radiological characteristics of these tumors is given. Emphasis is placed on treatment philosophy and objectives as well as on surgical technique. Our results and the complications in treating 95 children with spinal cord tumors are outlined.

Astrocytoma↗
PubMed1988

Brainstem haematomas: review of the literature and presentation of five new cases.

Fifty-one cases of brainstem haematoma that have undergone neurosurgical intervention since Finkelnburg's first exploration in 1905, are presented, together with five new cases. The location, incidence, aetiological and pathological factors, as well as clinical syndromes are reviewed. Diagnostic criteria are presented. The distinction between brainstem "haematoma" and "haemorrhage" is stressed. A retrospective comparison of 56 surgically treated cases and 31 conservatively managed cases is made, as is an analysis of the natural history of the disease process. Based on currently available data, the conclusion is drawn that patients with brainstem haematomas fare quite well after surgical therapy.

Adolescent↗
PubMed1987

Volumetric quantification of intracranial and ventricular volume following cranial vault remodeling: a preliminary report.

This preliminary study documents preoperative and postoperative changes in cerebral tissue as well as intracranial and ventricular volume in patients who underwent cranial vault remodeling for craniosynostosis. The documentation and calculations were provided from CT data according to a craniofacial protocol. Three-dimensional images were then obtained of the preoperative and postoperative skulls and cerebral tissues. From these data, comparisons of preoperative and postoperative volumes of the cerebral tissue and ventricles could be examined. In one case, a frontal bone advancement combined with anterior cranial vault remodeling was associated with an increase in intracranial volume of 110 cc (8 percent) and a ventricular volume increase of 112 percent. The reported technique should allow more complete evaluation of the preoperative pathology and documentation and prediction of the projected intracranial and ventricular volume changes.

Brain↗
PubMed1987

Closure of extensive and complicated laminectomy wounds. Operative technique.

Fifty-eight patients with previously irradiated intramedullary spinal cord astrocytomas underwent laminectomy for radical excision of their tumors. A high incidence of postoperative cutaneous cerebrospinal fluid fistulas and large pseudomeningoceles following routine closure prompted the development of an alternative method of wound closure using mobilized musculofascial flaps. The authors describe the surgical techniques and pitfalls to be avoided during the closure of complicated laminectomy wounds.

Astrocytoma↗
PubMed1986

Intramedullary spinal cord tumors: MR imaging, with emphasis on associated cysts.

Fifteen magnetic resonance (MR) imaging studies in 16 patients with intramedullary spinal cord lesions were correlated with surgical findings in all patients and with results of intraoperative spinal sonography (IOSS) in eight. Tumor extent was defined accurately in all but two patients by MR imaging; these lesions were found at surgery to have been underestimated by one to two vertebral body segments. Most tumors had lengthened T1 and T2 relaxation times. Intratumoral cysts were detected by MR imaging in one of eight cases, and rostral and caudal cysts were defined in only two of ten cases. The poor detection rate is attributed to poor spatial and contrast resolution. Preoperative MR imaging to define the extent of cord enlargement and IOSS to define cystic structures appears to be the optimal method of tumor management pending our further study.

Adolescent↗
PubMed1985

Sonography of the spine and spinal cord.

Sonography has proved to be a valuable method for the examination of the spine in children with spinal dysraphism. It facilitates the diagnosis of meningocele, lipoma, and/or spinal cord tethering rapidly and noninvasively. It is suggested that sonography be utilized for screening infants with neurocutaneous signature of spinal dysraphism.

Astrocytoma↗
PubMed1984

[Intraoperative localization of space-occupying intracranial processes using ultrasound].

During a two-year period, intra-operative ultrasonic explorations were performed in 44 patients for the purpose of localisation of intracranial masses. This facilitated accurate intraoperative assessment of the location and consistency of the mass. We consider operative ultrasound to be an invaluable adjunct to surgery of small intracerebral masses.

Brain Edema↗