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Biomedical subjects

F J Criado

Publications and source records attributed to F J Criado.

At least 37 records · Page 2Linked to original sources
PubMed1998

Healing of colonic ischemic anastomoses in the rat: role of superoxide radicals.

PURPOSE: The aim of this study was to evaluate the role of superoxide radicals in the healing of ischemic colonic anastomoses in the rat. METHODS: Adult male Wistar rats were used in a factorial design with two factors (normal or ischemic colonic anastomoses) each having two levels (treatment with saline or allopurinol). Colonic anastomoses were performed either in normal or previously devascularized colons (ischemic anastomoses) at identical locations, using the same technique. On the fourth postoperative day, animals were killed, and specimens were taken for determinations. RESULTS: Ischemic anastomoses displayed significant increases in superoxide radical (assayed as superoxide anion), superoxide dismutase, and glutathione peroxidase concentrations. Bursting strength and hydroxyproline levels were also significantly lower in these anastomoses. Allopurinol administration elicited a significant decrease in superoxide anions and raised both bursting strength and hydroxyproline levels only in ischemic anastomoses. CONCLUSIONS: Superoxide radicals are involved in the delay in healing of ischemic anastomoses. Allopurinol lowers superoxide anion production and has beneficial effects on the cicatrization of ischemic anastomoses.

Anastomosis, Surgical↗
PubMed1998

Percutaneous femoral puncture for endovascular treatment of occlusive arterial lesions.

BACKGROUND: Percutaneous femoral arterial access is a most important and difficult aspect of endovascular intervention, and the source of most complications. METHODS: A retrospective review was made of the authors' 9-year experience with 755 femoral punctures for the endovascular treatment of occlusive disease. The main focus was the evolving success rate with percutaneous arterial entry and the incidence of access-related complications. RESULTS: Cutdowns were frequent during the first 2 years, 54% and 17%, respectively, decreasing to 5% or lower by the third year. The incidence of femoral hematoma and other complications mirrored the same learning curve. After cutdown, wound infections and lymph leakage occurred in 2.4% each, and prolonged significant pain in 5%. CONCLUSIONS: Percutaneous puncture is a crucial skill in endovascular intervention. Practicing vascular surgeons can expect a significant learning curve. Performance can be optimized through intensive basic and advanced training and preceptorship. The cutdown approach is neither necessary nor acceptable for most endovascular procedures.

Arterial Occlusive Diseases↗
PubMed1998

Outpatient endovascular intervention: is it safe?

PURPOSE: To evaluate the feasibility and safety of outpatient percutaneous endovascular intervention in the treatment of arterial occlusive disease. METHODS: The records of 134 patients who underwent 151 outpatient endovascular procedures between 1992 and 1997 were reviewed retrospectively. According to established protocol, focal lower limb (n = 145) and subclavian (n = 6) arterial lesions requiring relatively straightforward endoluminal interventions were appropriate for outpatient management provided the patients were free of significant comorbidities. A percutaneous transfemoral approach was used for lower limb lesions, while subclavian angioplasty was performed via a brachial access. Heparin anticoagulation was administered conservatively. Patients were discharged 3 hours after sheath removal. RESULTS: The majority (98%) of patients were discharged as planned. Three (2%) patients were observed overnight in the hospital for treatment of acute iliac artery thrombosis, puncture-site bleeding, and suboptimal angioplasty. No patient required hospitalization following discharge. Periprocedural morbidity was confined to 2 (1.5%) groin hematomas and 1 (0.7%) femoral pseudoaneurysm. CONCLUSIONS: Outpatient endovascular intervention appears safe; however, proper case selection and technical excellence are inseparable components for the success of this strategy.

Aged↗
PubMed1998

The talent endoluminal AAA stent-graft system. Report of the phase I USA trial, and summary of worldwide experience.

In the United States, the Phase I Feasibility Study under IDE G970065 was approved by the Food and Drug Administration on 04/11/97. The approved protocol called for implantation of the bifurcated Talent spring stent-graft system on patients who are high-risk candidates for conventional surgery because of cardio-respiratory, medical, general, or local anatomical reasons which would likely complicate the technical execution of the operation or be accompanied by a high expected mortality rate. Patient enrollment was complete with 16 cases as of September 26, 1997. This was a multicenter experience involving five different sites. This is an ongoing study and patients, of course, will continue to be followed longitudinally. Phase II will likely be approved by the FDA for initiation in January or February of 1998. Standard-risk AAA patients will be entered into the study at this time; comparison with concurrent controls will be used for comparison with conventional surgery.

Adult↗
PubMed1997

Percutaneous revascularization of an extensively diseased saphenous vein bypass graft with a saphenous vein-covered Palmaz stent.

A 68-year-old man developed unstable angina 12 years following coronary artery bypass surgery. Angiography revealed an extensive area of severe stenosis and diminished distal flow in a right coronary artery vein bypass graft. Given the high distal embolism rate associated with conventional catheter-based treatment of old degenerated vein grafts, the diseased area was "relined" with a composite autologous saphenous vein-covered stent. The procedure was performed using modifications of standard PTCA methods and resulted in a widely patent, smooth lumen. This initial case demonstrates that a degenerated saphenous vein graft can be successfully revascularized with an autologous saphenous vein-covered stent in an attempt to minimize the potential complications of standard catheter-based revascularization methods.

Aged↗
PubMed1997

Evolving indications for and early results of carotid artery stenting.

BACKGROUND: While carotid endarterectomy continues to be the gold standard of treatment for most patients with significant carotid artery disease, there are cases where lesion or anatomy-related factors create situations less than ideal for conventional surgery. Other therapeutic modalities, such as endoluminal stenting, may represent reasonable options for such patients. METHODS: Thirty-three patients with 70% or greater internal carotid artery lesions were treated by endovascular stent placement from July 1994 through June 1996. Indications included transient ischemic attacks in 20 and previous stroke in 4; and 9 were asymptomatic. RESULT: Stents were placed successfully in all instances. Mortality and stroke rates were zero. All patients remained asymptomatic during follow-up (mean 8 months), and stent patency by duplex ultrasound has been 100%. A single instance of intrastent restenosis has been observed. CONCLUSIONS: Endoluminal stenting is an investigational technique of unproven efficacy and long-term durability. Yet it appears technically feasible, and possibly reasonable, as an alternate option for cases unfavorable for standard surgery.

Carotid Stenosis↗
PubMed1997

Miniincisional ligation of incompetent perforating veins of the legs.

PURPOSE: The purpose of this study was to determine the effectiveness of a new surgical procedure for interrupting incompetent perforating calf veins in patients with recalcitrant venous ulcers. METHODS: Eighteen patients with venous ulcerations in 26 limbs had incompetent perforators diagnosed by duplex scanning. All were taken to the operating room, where the fascial defects through which the perforators coursed were obliterated by a "pursestring" permanent suture placed on the leg fascia. Follow-up duplex scanning was carried out within 2 weeks of the procedure and every 6 months thereafter. The mean follow-up in this series was 22 months. RESULTS: Initial success in obliterating the perforators was noted in 24 (92.3%) of 26 legs. Three subsequent failures occurred within 6 months for a midterm success rate of 80.7%. No wound complications or infections occurred. All ulcers healed within 6 weeks of the procedure (mean, 23 days) in the successfully treated patients. CONCLUSIONS: Miniincisional ligation of incompetent perforating veins is easy to perform and has very encouraging early results.

Adult↗
PubMed1996

The treatment of focal aortic arch branch lesions with Palmaz stents.

PURPOSE: The purpose of this study was to evaluate the safety and effectiveness of Palmaz stents as a less morbid alternative to traditional surgery for focal aortic arch branch lesions. METHODS: Twenty-two patients with symptoms and a mean age of 61.3 years were treated from July 1991 to May 1995 with 26 stents at the following locations: 8 innominate artery, 5 left common carotid artery, 1 right common carotid artery, and 12 left subclavian. Procedures were carried out in an operating room with patients receiving either local anesthetic in 12 cases or general anesthetic in 10. Surgical exposure of either the cervical common carotid or brachial artery allowed precautionary distal clamping before retrograde stent deployment to prevent atheroembolization. RESULTS: Initial success was possible in 92.3% (24 of 26) of cases. There were no strokes or deaths. During a mean follow-up period of 27 months, 22 of 26 (85%) vessels have remained patent and the patients symptom free. CONCLUSION: Focal aortic branch lesions can be effectively and safely treated with Palmaz stents.

Adult↗
PubMed1996

Techniques for endovascular recanalization of supra-aortic trunks.

The supra-aortic are no stranger to endovascular interventions. Since the 1980s, interventionists have been evaluating and refining the use of transluminal techniques for recanalizing stenotic and occlusive lesions in these large-bore, high-flow vessels. The authors present their methodologies for evaluating, selecting, and treating supra-aortic lesions with balloon angioplasty and stenting. Helpful suggestions are offered for optimizing the outcome of these endovascular approaches to atherosclerotic occlusive disease in the supra-aortic trunks.

Angioplasty, Balloon↗