[Experience using tidazin--a new Russian selective stimulant of histamine H2 receptors].
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Biomedical subjects
Publications and source records attributed to F I Komarov.
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Clinical and echocardiographic studies in 25 chronic coronary patients with atrial fibrillation paroxysms following intravenous administration of 0.61-3.8 mg/kg Rhythmilen or its single oral dose (1.25-2.5 mg/kg), as well as during prolonged treatment with 400-600 mg Rhythmilen daily, demonstrated that their myocardial contractility parameters were reduced in the absence of an attack. Contractility parameters were not basically affected where the drug had no effect. Rhythmilen is an effective anti-arrhythmic agent: it arrests atrial fibrillation paroxysms in 73% and maintains the sinus rhythm when used preventively in 82% of cases.
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The authors substantiated a new approach to the problem of peptic ulcer in terms of chronobiology. The presence of external and internal dyschronism in this disease was shown. Basing on the observations of protein synthesis in the gastric mucosa and clinical observations a review of the concepts of the time-period of exacerbation of gastric and duodenal ulcers was proposed.
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