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Biomedical subjects

F Huth

Publications and source records attributed to F Huth.

At least 55 records · Page 3Linked to original sources
PubMed1976

[Cogan's syndrome with angitis of cranial nerves, aortitis, endocarditis, and glomerulonephritis (author's transl)].

A 34-year-old woman died of left-heart failure due to combinated aortic-valve disease three years after manifestation of Cogan's syndrome characterized by sudden inner-ear deafness, loss of equilibrium, interstitial keratitis, and progressive loss of vision during pregnancy. At necropsy there was evidence of recurrent endocarditis of the aortic valves with stenosis and regurgitation, severe angitis of the thoracic aorta with marked secondary sclerosing changes as the cause of the heart failure. Angitis within the optical fasciculus and stato-acoustic nerve was the cause of the vestibular and optical defects. Primary changes in the visual and auditory cortices, the retina and inner ear were excluded as causes. There was also acute membrano-proliferative glomerulonephritis, which may have been coincidental.

Acute Disease↗
PubMed1976

[Experimental investigation of cardiac lymph vascular system (author's transl)].

Ligatures of the supracardiac lymph vessels and the cardiac lymph nodes have been performed in fifty mongrel dogs. Comparative electrocardiographical, light microscopical, scanning and transmission electron microscopical investigations were done one day to three months after surgery. The demonstrated findings confirmed former results concerning the topography and the microstructure of the cardiac lymph vascular drainage system. In addition, the comparative functional and morphological examinations made evident the pathogenetic importance of cardiac lymphostasis. Lymphostatic oedema has been discussed as a pathogenetic co-factor for human heart diseases. Therapeutic attempts on experimental cardiac lymphostasis with i.v. - application of Coumarin-Troxerutin were without effect.

Animals↗
PubMed1976

[The articular capsule in idiopathic hypertrophic osteoarthropathy (author's transl)].

The results of clinical roentgenological, cytological examinations as well as the histological examination of biopsy material with electron microscopy are reported for two cases of primary idiopathic hypertrophic osteoarthropathy. In both cases, a watchglass nail was present in the hands and feet; clubbed, distended knee, ankle and wrist joints; appositional enlargement of the shaft of the long bones; the hands and the phalanges of the foot as well as arthralgia and an hyperhidrosis. The morphological examination of biopsy material confirmed the already established increased periosteal bone enlargement. In addition, a fibrosis of the synovial membrane with thickening of the fibrous tissue matrix and increased vascularization of the synovial membrane could be established. Inflammatory processes could be excluded. The reported findings could be attributed to a generalized defect in hormonal or enzymatic regulation of the mesenchym. The vascularization can be explained as a reaction to the lengthening of the transit route between vessels and joint lumen. The thickening of the connective tissue together with the lengthening of the transit route is considered to be an essential causal factor in the arthralgic complaints of strain in hypertrophic osteoarthropathy.

Adult↗
PubMed1976

[The synovial membrane of the temporomandibular joint. Histological and morphometric studies on 106 temporomandibular joints].

Thickness of synovial lining cell layers, cytological appearance of synovial cells, the grade of fibrosis, the distance between subsynovial blood vessels and synovial surface, possible inflammatory infiltrations etc. have been controlled in synovial preparates of 106 mandibular joints. The age dependent fibrosis of the synovial tissue has been demonstrated.

Adult↗
PubMed1976

[Needle biopsy in gout and pseudogout (author's transl)].

INTRODUCTION: Radiological and morphological findings in advanced arthritis urica and pyrophosphate arthropathy are well known. In contrast, the early changes of synovial membrane in these disturbances of metabolism pose diagnostic problems. With the assistance of various cytological techniques and polarizing microscopical as well as electron microscopical investigation it was examined to what extent needle biopsies can be helpful in the differential diagnosis of gout and pseudogout. MATERIAL AND METHODS: In 8 patients with gout and 11 patients with pseudogout synovial fluid and small tissue specimens could be obtained with the aid of the Parker-Pearson needle. Both fluid and tissue specimens were investigated light and electron microscopically. Cell counts were evaluated in a Rosenthal chamber. The differentiation of the cells in stained smears was done by counting 200-600 cells per case. Crystals were identified by polarizing microscopy in wet preparations of freshly aspirated synovial fluid. RESULTS: Polarizing microscopy of synovial fluid detected intra- as well as extracellular urate and pyrophosphate crystals. The wedge-shaped urate crystals and the larger partly polygonal pyrophosphate crystals showed different polarizing microscopical properties and a negative birefringence. The absolute cell counts in gout were higher than those in pseudogout. The relative cell counts of the different cell types in synovial fluid showed more variation in gout than in pseudogout. Cases with acute gout developed a relative leukocytosis in contrast to a relative lymphocytosis in chronic gout. A relative leukocytosis was constant in all patients with pseudogout. Sclerosed areas with scarce and plump villi as well as sometimes hyperplastic and polymorphous synovial cell layers could be demonstrated histologically in the tissue specimens of the needle biopsies in cases with gout. Urate crystals were less frequent in specimens fixed in formalin. The histological alterations in pseudogout were uniform, 2-4 rows of slightly pleomorphic synovial cells lined the inner surface of the joint capsule, sclerosing alterations were less frequent. Pyrophosphate crystals and calcified particles were seen within the synovial lining cells, the connective tissue and the enodthelial cells of the blood vessels in pseudogout specimens. Intra- as well as extracellular crystals could also be demonstrated with the aid of scanning electron microscopy in sediments of synovial fluid in gout and pseudogout. Transmission electron microscopical investigations of synovial tissue specimens detected proliferated and pleomorphic synovial lining cells in gout in contrast to a more monomorphic appearance of these cells in pseudogout. The crystals were washed out during the preparation techniques for transmission electron microscopy so that needle-like empty spaces resulted within cytoplasm of the phagocytic cells. These clefts were surrounded by phagosomal structures and densified cytoplasmic ground substance; sometimes they were also lined by membranes...

Aged↗
PubMed1976

[Results of animal experiments concerning the carcinogenic effect of fibrous dusts and their interpretation with regard to the carcinogenesis in humans (author's transl)].

After reviewing the hypotheses about the pathogenesis of asbestos-induced malignant tumours we report about experimental data on animals. A high incidence of tumours (most of them mesotheliomas) was induced in rats by intraperitoneal injection of fibrous dusts (chrysotile, palygorscite, crocidolite, glass fibres, nemalite). Treatment with 8 types of granular dusts led though applicating a high dosage (50--100 mg) to neoplasms in only a small percentage of animals. After intraperitoneal application of 2 mg of chrysotile, crocidolite or glass fibres a tumour incidence in a range from 16% to 38% was observed and fibrous reaction was slight. 100 mg of milled chrysotile with relative short fibres (99.8% less than 5 mum, 99.5% less than 3 mum) caused no asbestosis, nevertheless tumours developed in 32% of the rats. Intraperitoneal injection of fibrous dusts also induced mesotheliomas in mice, however not in Syrian hamsters and guinea pigs. Our results point out that the fibrous shape of asbestos dust causes its carcinogenic effect and that furthermore other fibrous dusts can also lead to tumours. Prerequisites are an adequate measure of the fibres and their constancy in the tissue. For these two parameters no exact dates exist. It is estimated that a fibre with a diameter less than 1 mum and a length less than 3 mum exert a cancerogenic effect. Furthermore, a sequence of other factors has an importance for the dose-effect relationship of fibrous dusts. Material of the fibres plays a role in so far it defines the effect producing amount of fibres. The relevance of the results of animal experiments to man is discussed especially with regard to the cancerogenic effect of glass fibres.

Animals↗
PubMed1976

[Wall structure of cisterna chyli in humans studied by light and scanning electron microscopy].

Comparing light and scanning electron microscopy of a chronically lymphostatic and two normal cisternae chyli made visible a normally folded and smoothened (under load) cisternal wall. Different orifices of the supplying lymph-collecting vessels with varying valve structures were seen. The functional meaning of the orifice types and of the valves for the uptake of lymph and chylus into the cisterna as well as for the blockage of lymphatic reflux out of the filled cisterna were discussed.

Adult↗
PubMed1975

[The effect of acetyl-salicylic-acid and a pyrido-pyrimidine-derivate on the rejection of allotransplanted canine kidneys (author's transl)].

The effects of anti-thrombotic drugs-Acetyl-salicylic-acid and 2-Piperazinly-4-thiomorpholino-pyrido(3,2-d)-pyrimidin-sulfat-trihydrat-on rejection reactions of renal allografts in dogs have been studied. From the clinical point of view no effectiveness of the two drugs can be found, whereas the histological findings do clearly show diminished rejection reactions in the Acetylsalicylic-acid group.

Animals↗
PubMed1975

Alteration of the rabbit aorta following feeding of cholesterol diet in combination with sheathing of aortic segments by polyethylen tubes.

Nutritional disturbance and blockage of drainage of the vascular wall which were considered to play an impoetant role in the pathogenesis of arteriosclerosis were experimentally produced by aortic sheathing previously (Huth et al., 1974). Alteration of the rabbit aorta following feeding of cholesterol diet in combination with sheathing of aortic segments by polyethylen tubes is reported in this paper. The results were as follows: 1. When rabbtis were fed a cholesterol diet, atherosclerotic lesions formed in the intima of the aorta. 2. When rabbits were fed a cholesterol diet with simultaneous aortic sheathing, aortic atherosclerosis was also produced within the sheathed segments. 3. When rabbits were fed a cholesterol diet after formation of intimal thickenings within the sheathed segments, lipid deposition was scarce within these segments. The results suggest that among the pathogenetic factors of atherosclerosis a disturbance of vascular nutrition and a blockage of vascular drainage may be of greater importance than hypercholesterolemia.

Animals↗
PubMed1975

[Morphometric investigations' on synovial membranes of human knee joints. Statistical analysis (author's transl)].

Sixty knee joints of 49 autopsies and 10 amputated legs were examined histologically by specimens removed from eight locations. The criteria considered were: configuration of the surface, number of rows of synovial cells, sizes of bodies and nuclei of the synovial cells, position of the blood vessels to the synovial surface, degree of sclerosis both of the subsynovial connective tissue and blood vessels, and infiltrates of inflammatory cells. These parameters were recorded in tables, and 3,600 individual data were statistically evaluated by the aid of a PDP-12-computer. Survey of all findings shows that the age changes of the synovial membrane are relatively slight. With increasing body weight sclerosis of the synovial blood vessels progresses, but these vessels are sometimes spared in generalized arteriosclerosis. The greatest number of individual tissue changes is noted in the fat pad, medial and lateral capsular parts. Thus the synovial membrane of these parts may be regarded prominently reactive and of special value for the diagnosis of synovial changes. Since these parts are easily accessible at routine arthrotomies, they are recommended as the sites for diagnostic biopsies.

Adolescent↗