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Biomedical subjects

F Hummel

Publications and source records attributed to F Hummel.

7 recordsLinked to original sources
PubMed1978

[Double blind study on maprotiline, an example of a multidimensional psychopharmacologic experiment (author's transl)].

Antidepressive therapy with maprotiline was accompanied by blood level determinations psychological clinical and electroencephalographical assessments. It was the aim of the study to introduce objective methods in psychotropic drug therapy and to look for a relationship between blood level and clinical outcome, EEG and psychological data. We found a "therapeutical window" of blood levels between 300 to 600 ng/ml of maprotiline (oral dose of 75 or 150 mg per day). There is also a relationship between clinical outcome rated by the Hamilton-Depression-Scale and the d2-cancellation-test.

Administration, Oral↗
PubMed1976

[Multidimensional pharmacopsychiatry in gerontopsychiatry: studies on the therapy with tricyclic antidepressant drugs (author's transl)].

A Concept for the multidimensional assessment and correlation of serum level and outcome of therapy with psychomopharmaca with chemical, psychological, psychophysiological, electroencephalographical and clinical methods is shown. It is possible by this method to correlate clinical outcome to serum level and effect of the drug and to objectivate the efficacy of the pharmacon. Applications in Gerontopsychiatry are discussed.

Aged↗
PubMedDate not supplied

Developing outcome assessment methods.

Describing the development of an outcome assessment method for accreditation, the authors discuss development of criterion definitions and the evaluation of results from a pilot study using student portfolios. The subsequent design of an outcome assessment tool to provide concrete, objective data, the evolution of the evaluation process using this tool, and how the outcome data are currently used for curriculum evaluation are discussed.

Accreditation↗
PubMedDate not supplied

Serum levels of extracellular matrix in acute pancreatitis.

BACKGROUND/AIMS: Elevated levels of serum markers of extracellular matrix, i.e., the amino-terminal procollagen-III-peptide, hyaluronic acid and laminin are found in various diseases. The study aims to examine a panel of these parameters in patients with acute pancreatitis and correlate them with the course and severity of the disease. METHODOLOGY: We prospectively examined the time-course of procollagen-III-peptide, hyaluronic acid and laminin in 24 consecutive patients with acute necrotizing (n = 13) or edematous (n = 11) pancreatitis. Patients with chronic pancreatitis with (n = 10) or without (n = 17) acute pain, and 6 patients in complete remission after an episode of acute pancreatitis as well as healthy individuals served as controls. In addition, serum levels of collagen VI and undulin were followed in 10 and 9 patients with acute necrotizing pancreatitis, respectively. RESULTS: The serum concentrations of procollagen-III-peptide, hyaluronic acid and laminin were significantly higher at the onset of acute necrotizing pancreatitis compared to edematous pancreatitis and the controls. They returned to almost normal levels during the course of the disease when the patient recovered, but remained elevated in patients with a lethal course. Laminin allowed us to discriminate between patients with necrotizing pancreatitis from all other forms of pancreatitis on admission (specificity 82%, sensitivity 92%, PPV 86%, NPV 90%). Collagen type VI levels were 2-3-fold higher in sera of patients with acute pancreatitis than in healthy controls, whereas the results for undulin were inconclusive. CONCLUSIONS: Since markers of matrix metabolism (especially laminin) are differently elevated in acute necrotizing versus edematous pancreatitis, we suggest that they might be used as parameters for the outcome.

Acute Disease↗