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Biomedical subjects

F Horak

Publications and source records attributed to F Horak.

At least 91 records · Page 5Linked to original sources
PubMed1987

Oral hyposensitisation with enteric-coated allergens as extension therapy following a basic subcutaneous course of injections.

We investigated in grass-pollen-sensitive adults the efficacy and safety of a therapeutic hyposensitisation regimen consisting of a basic pre-seasonal course of tyrosine-absorbed glutaraldehyde-modified grass pollen extract (Pollinex), followed by oral extension treatment using encapsulated, particulate, enteric-coated grass pollen allergen. The daily recorded symptom scores both of these patients and of others treated with complete basic and extension courses of Pollinex indicated that both sets of patients had fared better during the grass pollen season than control patients who had received only the basic Pollinex injections.

Administration, Oral↗
PubMed1986

A multicenter trial of immunotherapy with alginate--conjugated grass pollen extract.

Conjuvac, a new generation of allergen extracts, has been developed to meet the need for improved characterization, purification, and standardization. Conjuvac consists of a dialyzed, standardized aqueous allergen extract chemically conjugated to a sodium alginate carrier and lyophilized in single-dose vials, thus ensuring stability until reconstituted with sterile water just before each injection. A preliminary study of Conjuvac 2 Grass by Pegelow (1984) involving a small number of patients showed this extract to have potential advantages. Accordingly, a study involving more patients was undertaken: two different maintenance dose levels of Conjuvac 2 Grass were investigated and compared to a pyridine-extracted, alum-precipitated two-grass extract called Allpyral, which in previous double-blind trials has been shown to be effective. The trial, which included 125 patients with hay fever and which extended over 2 years, involved ten allergists from seven European countries. Overall, the Conjuvac high-dose regimen proved slightly superior to Allpyral without any increased incidence of side effects, and all treatments stimulated marked increases in specific IgG levels without raising IgE levels.

Adolescent↗
PubMed1985

The allergen quick test: a simple allergy test to prove existing sensitization.

We have developed a new method of allergy skin test. The main advantages of the allergen quick test (AQT) are its simple and rapid procedure and its usefulness in screening trials for everyday clinical practice. The equipment consists of a disposable test applicator which is pre-loaded with the allergen solution to be tested. The AQT was used on 3800 subjects in a screening trial, and has been performed by several ENT specialists in their clinical practices since 1979. Evaluation of the results obtained confirms that this developed method is safe, easy to use, and accurate.

Child↗
PubMed1985

Manifestation of allergic rhinitis in latent-sensitized patients. A prospective study.

In a prospective study of allergic rhinitis in latent-sensitized young patients, 114 children were observed over a period of 4 years. At the beginning of the study, all patients were found to be sensitive to inhalant allergens but without any signs of clinical manifestations. Each patient's rhinologic and allergic status was checked in yearly follow-up examinations to determine the incidence of allergic rhinitis becoming clinically apparent and to define special risk characteristics. During the period of observation, 53% of the children developed manifest allergic rhinitis, while an additional 5% developed clinical symptoms of allergic bronchial asthma. Patients who showed monovalent sensitivity formed a special risk group, especially if they were sensitized to pollen. A continuously increasing serum IgE titer, increased concentrations of specific IgE, and skin tests were used as prognostic criteria to predict imminent clinical manifestations.

Adolescent↗
PubMed1985

[Flexible ENT endoscopy--video technic].

This study discusses the solutions to the problem of documenting moving processes in the field of otolaryngology. A flexible bronchoscope and video equipment connected to it are presented as a specific solution of the problem, with ample of observations. A technical comparison is used as the basis for a discussion of the pros and cons of the video and film techniques. A successful arrangement of examination facilities illustrates the future of flexible-endoscope techniques in the field of otolaryngology.

Adult↗
PubMed1984

Collaborative clinical assay of the biological potency of allergen skin-test extracts.

A multicentre collaborative clinical trial has been made at one centre in each of six countries to decide if the potency of allergen extracts can be determined satisfactorily by skin-prick tests in man. Although there was considerable variation in potency of antigen when determined in different patients, if a sufficiently large group (n = 54) of persons were tested, it was shown to be feasible to compare potencies of sequential batches of the same specificity, and also of antigens of different specificities. It was shown that batches of mite extract were weaker than that of a grass pollen, but it proved to be a simple matter to adjust the concentration to give the same biological potency.

Adolescent↗
PubMed1983

[Combination aerosol for bronchial asthma in childhood].

40 children with clinical diagnosis of bronchial asthma aged 8--14 years, 39 with allergic disposition, were investigated. Acute therapeutic and protective effect on frequency of asthmatic attacks, pulmonary auscultation and lung function (FEV1, PF, FVC) by application of Fenoterol and Ipratropium as combination aerosol were registered. Over a period of 4 weeks we could reduce the frequency of attacks nearly to the half. 10 and 20 minutes after aerosol application we showed a good improvement of pulmonary ventilation. Only on children with severe asthma bronchiale an exclusive treatment with Berodual seems to be of modest protective effect.

Adolescent↗
PubMed1983

[Rhinogenic adenocarcinoma in wood-workers].

In a retrospective epidemiological study, 127 patients with malignant tumours of the nose and paranasal sinuses were studied during a period of ten years. There was a remarkable coincidence between adenocarcinomas and adenocystic carcinomas on the one hand, and patients who were occupationally exposed to wood dust on the other; it was established that the duration of this exposure in the course of their professional life had been between 15 and 35 years. Adenocarcinomas represented 22.8% of the total amount of malignant tumours. The share of the woodworkers in the total number of occupationally active patients in our area of examination was 2.14%, whereas 17.2% of the patients with adenocarcinoma and adenocystic carcinoma had been occupationally exposed to wood dust. The statistical examination of the postulated connection between exposure to wood dust and the occurrence of malignant tumours of the histological type of the adenocarcinoma and adenocystic carcinoma, showed a highly significant correlation.

Adult↗
PubMed1983

[Assessment of therapeutic success of a specific immunotherapy of grass pollen allergy].

So far it has not been possible to clearly objectify the success of a specific immunotherapy. The aim of the study is to determine which immunological parameters and which clinically biological observations can be used in order to verify a therapeutic success. In four different groups of patients suffering from grass pollen allergy, different specific immunotherapies were carried out pre-seasonally. Continuous observations of patients symptoms together with continuous measurements of the concentration of pollen in the air, of the usual whereabouts of the respective patients, as well as the determination of specific IgE and IgG antibodies before and after the immunotherapy, and the observation of the IgD titre were used as basis of assessment of the efficacy of the specific immunotherapy. Statistical evaluation showed that only the pollen-exposure measurement as compared to the complaints of the individual patients can yield exact information on the therapeutic success. The immunological parameters, in particular the determination of the specific IgG antibodies, are not statistically related to the actual therapeutic efficacy.

Humans↗
PubMed1982

Disophrol syrup versus Rinomar syrup in the treatment of allergic rhinitis in children.

In this single-blind study, the efficacy and safety of Disophrol Syrup was compared to Rinomar Syrup in seventy-eight paediatric patients with seasonal allergic rhinitis. Patients took 5-10 ml of the randomly assigned medication three to four times daily for a 2-week period. Severity of nasal obstruction, nasal secretion and mucosal swelling was graded and patient response to each week of therapy evaluated. An overall favourable response to Disophrol Syrup was observed in thirty-one out of thirty-five (89%) patients and in thirty out of thirty-five (86%) patients in the Rinomar group. No statistically significant difference in patient response to therapy between treatment groups was noted and no mentionable adverse reactions were reported.

Brompheniramine↗
PubMed1982

The protective action of fluocortin butylester (FCB) in the nasal antigen provocation test: a controlled double-blind, crossover study.

Fluocortin butylester (FCB), a locally active corticosteroid, was inhaled as a fine powder mixed with lactose using the rhinolator in a comparative double-blind, crossover study against placebo. Fifty patients of both sexes and aged from 16 to 46 years with an established seasonal allergic rhinitis, but free of symptoms, took part in this trial. The determination of the protective action after allergen provocation was performed after seven days treatment with 4 mg FCB or placebo. Measurements of the nasal resistance and the temperature were taken after provocation. The symptoms of nose and eyes were recorded. The protective effect of FCB against nasal provocation with grass pollen extracts was statistically proved.

Adolescent↗
PubMed1982

[Frequency of inhalation allergies in children of rural areas as compared to urban areas].

The morbidity of inhalation allergies which was proved to exist on the basis of a screening test involving schoolchildren in a big city (Vienna) in 1979 was compared to that in school children in a rural area (Wiener Neustadt region). The study involved 651 children aged 8, 12 and 15-16 who were examined under the same conditions as the Vienna school children had been examined previously. Case histories were prepared with the help of questionnaires and each child was subjected to a skin test against grass species, pollen and the house-dust mite. If one of the two criteria was positive, blood samples were taken for specific serum-IgE determination by means of RAST and whole-blood IgE-level by means of PRIST. In the group of Wiener Neustadt schoolchildren aged 8, 8% suffered from manifest allergies (7% in Vienna) and 5% from latent allergies (7% in Vienna). In the group of 12 year old children, 11% suffered from manifest allergies (11% in Vienna) and 8.5% from latent allergies (8% in Vienna). A definite conclusion concerning the group of children aged 15-16 cannot be drawn, since the samples were not comparable. Since the results obtained in Wiener Neustadt and Vienna were largely identical, this proves 1. the reliability of the results concerning the percentages of allergic children; 2. that the number of allergies increases with the age of the children; 3. that there is no statistical difference in the allergy distribution between children coming from rural areas or from big cities.

Adolescent↗
PubMed1981

[Determination of the morbidity due to inhalation allergies in Viennese schoolchildren (author's transl)].

According to the medical literature there is a huge variation of between 0.4 and 49% of the population reported to suffer from inhalation allergies. In general, however, reference is made time and again to the increasing incidence of allergies, particularly in children. In the present study 3,158 Viennese schoolchildren of three different age groups (8, 12, and 16 year-olds) were tested for inhalation allergy. Precise case histories were elicited and skin tests carried out in all children, and if one of these criteria was positive an immunological examination was performed in addition, in order to detect any specific antibodies in the serum. A point system was used for the diagnosis of allergy. The tests showed that 17.6% of the schoolchildren have an allergic predisposition, 10.1% suffer from clinically manifest allergy and 7.5% show a subclinical form. With advancing age the percentage of children suffering from allergies increases significantly: While among the 8 year-olds only 13.6% show a predisposition to allergy (6.8% manifest, 6.8% latent), the incidence among the 16 year-olds is as high as 22.1% (14.2% manifest, 7.9% latent). Among the allergy patients pollen sensitization was found to exist in 71.7% of cases, sensitivity to household-dust mites in 23.1% and 5.2% reacted to multiple allergens. The results of this study are discussed and compared with internationally obtained data.

Adolescent↗
PubMed1981

Influence of aerobiology and weather on symptoms in children with asthma.

Local and central European weather, pollen (Castanea and Poaceae) and spore (alternaria and cladosporium) counts, and asthmatic complaints and drug requirements (expressed as "attack score") were correlated in a group of 40 asthmatic children (21 with recurrent symptoms) during a summer holiday camp for 6 weeks. It was shown that there are significant correlations between the cumulative 24-hour pollen count over 6 weeks and the attack frequency. 2-Hourly counts or daily counts did not correlate with complaints. Consecutive 10-day averages of attacks and pollen and spore counts showed good agreement. The influence of local weather was negligible. Low pressure gradients or high atmospheric pressure was not beneficial. Improvements of lung function are ascribed to training effects.

Adolescent↗
PubMed1981

[Intelligence tests in patients suffering from chronic rhinopathy (author's transl)].

In 100 patients referred to the allergy clinic of the First Otolaryngological University Hospital of Vienna because of chronic rhinopathy an exact allergy diagnosis was carried out, comprising anamneses, skin tests and laboratory tests (Rast, Prist). The test results have yielded two or three diagnosis groups: patients with rhinitis vasomotorica nonallergica, rhinitis vasomotorica allergica, and pollinosis. In addition, in all patients an intelligence test by means of WIP (a short form of HAWIE) was carried out. The IQ of all patients tested is, on the average, significantly above the average of the normal population, the variation in all three groups being significantly below the average of the normal population. The reason for the low degree of variation is that patients with low IQ values were missing. Earlier tests carried out by this clinic (allergy-screening test in 3500 school pupils) had shown that the percentage of allergy patients among pupils with low IQs (special schools) and other children (secondary-schools) cannot be assumed to be of a varying degree. This fact demonstrates that although allergy patients with below-average intellectual ability do exist, they obviously do not consult the respective special clinics. This paper tries to explain this phenomenon and suggests that the socially lower strata be increasingly informed about the problem of allergy.

Adult↗
PubMed1980

[Reactions of the nasal mucous membrane as a consequence of allergological skin tests (author's transl)].

The nasal resistance and the temperature were measured in both nasal lumina immediately before and 20 minutes after an allergological skin test in 75 patients admitted to the allergy ward because of suspected allergic rhinitis. The measurements were carried out by means of a passive anterior rhinomanometer according to van Dishoeck and the results served as parameters of the reaction of the nasal mucous membrane. In order to secure the allergy diagnosis, the skin tests were supplemented by a carefully taken case history as well as by RIST and RAST. The 100 skin test series carried out in this investigation showed an increase in the resistance and in the temperature in most of those patients whose positive skin test result corresponded to the final diagnosis. These reactions were most pronounced in the screening tests, and were also confirmed by the herb, tree and mould tests. Furthermore, the temperature in the nasal lumen increased sooner than the resistance. Thereby it was possible to prove that in allergological skin tests the shock organ, i.e. the nasal mucous membrane in the cases discussed in this paper, shows a marked concomitant reaction if there is a manifest allergy to the allergens used in the test.

Adolescent↗