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Biomedical subjects

F Hoffmann

Publications and source records attributed to F Hoffmann.

At least 163 records · Page 9Linked to original sources

[Seasonal variations in the birth rate and conception rate within the last 200 years (author's transl)].

The monthly variations and the mean daily conception rates of 136,828 deliveries from 1803 to 1970 within the same population area are reviewed. It was found that the conception rate during the first half of the 19th century showed a rapid increase from its low during the winter to its maximum in May and that this pattern became much less pronounced in the 20th century. During the second half of the 20th century, the highest conception rate shifted for the first time to the summer and the third quarter of the year. In contradistinction to this development, the low of the conception rate during the winter from January to March is much less pronounced during the first half of the 20th Century and remains constant with the lowest conception rate in February into the second half of the 20th century. The importance of the influence of nature during the spring and winter and of the working and living patterns as well as the influence of family planning and recreational activities on the intensity of procreation in the human within the last 200 years is discussed.

Birth Rate↗

[Experimental study on cancerogenic activity of asbestos filters (author's transl)].

Wistar rats evolved many malignant tumors of different localisation. The tumors grew in the time of 8-14 months after oral application of asbestos filters which contained 53% Chrysotile asbestos. The number of tumors was statistically significant different not only in comparison to a control group which got talc only, but also to an untreated control group. The localisation of the tumors varied and so conclusions about organ specifity can not be drawn, when asbestos is applicated orally.

Administration, Oral↗

Side-effects of local anesthetics on the corneal epithelium of the rabbit eye.

The toxic side-effects of 0.4% Novesine and Chibro-Kerakain were investigated by scanning- and transmission electron microscopy in 15 rabbit corneae each in intervals of 3, 6, 10, 15 and 60 mins. The lesions following Kerakain were larger and occurred earlier. After 60 mins, the specimens after Novesine application showed an almost complete repair process, whereas after Kerakain the epithelial surface appeared to be functionally impaired.

Anesthetics, Local↗

[Herpes Simplex Keratitis under the Scanning lectron Microscope(author's transl)].

In 12 rabbits a dendritic keratitis could be provoked by applying a suspension of herpes viruses (Herpes virus hominis -- HVH type 1) onto their previously both uviolised and non-uviolised corneae. 4 days later ophthalmectomy was performed and the corneae were examined by the scanning electron microscope. Macroscopically, both in the uviolised eyes and the control eyes punctiform lesions of the corneae were observed. After short ray-treatment (3 min) no differences were present between the uviolised and non-uviolised eyes. At longer time of exposure (7--15 min), however, a more distinct alteration occurred in the uviolised eye. The scanning-electron-microscopical picture showed the dendritic lesions to be composed of numerous circular foci of 100 to 200 mu. There were no differences in the lesions of the uviolised and non-uviolised corneae. The fact that after ultraviolet ray-treatment a great part of the epithelial cells is sloughed off, but, nevertheless, the same dendritic lesions develop, contradicts the assumption of a morphological substrate of the epithelial cells being the inducing factor.

Animals↗

[A simple method for breeding major spore quantities of Clostridium butyricum to be used in experiments for tumour diagnostics and therapy (author's transl)].

A simple method is described for breeding major spore quantities of Clostridium butyricum using a modification of Berger's iron bouillon. The method allows the breeding of cultures with comparatively high spore-forming rates which is essential for the use of such spores in experiments in the field of early tumour diagnostics and tumour therapy.

Bacteriological Techniques↗

Scanning electron microscopy in ophthalmology.

In the context the technique of the scanning electron microscopy is described and the results are shown gained by the scanning electron microscope in ophthalmology. It is pointed out that questions specific to surface can be answered quicker and easier, if superificial microscopy together with the scanning electron microscope is used an additional source of information. Scanning electron optical pictures are very useful for ophthalmologic science.

Ciliary Body↗

[Pigment glaucoma. Scanning-electronmicroscopic findings. (author's transl)].

In case of a patient suffering from pigment glaucoma trabeculectomy was performed on both eyes. In one trabecular section the outer wall of Schlemm's canal, and in the other the trabecular framework were investigated by scanning-electronmicroscopy. The intertrabecular spaces were largely blocked by pigment granula, which, in some places, were stored in the clump cells of the iris. Even the outer wall of Schlemm's canal was dotted with pigment granula. The scanning-electronmicroscopic findings revealed the pigmental drainage blocking of the aqueous humour and explained the acute pressure rise in the pigment glaucoma with wide iridocorneal angle by an acute obstruction of the already largely blocked intertrabecular spaces.

Adult↗