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Biomedical subjects

F Hinman

Publications and source records attributed to F Hinman.

At least 73 records · Page 4Linked to original sources

Complications of vesicoureteral operations from incoordination of micturition.

Recently, a study was made of 8 boys with complications after corrective surgical procedures for dysfunction of the voiding mechanism. One of these patients already had been subjected to irreversible diversion before the basic disorder was recognized but the majority was treated with suggestion (often with hypnosis) as well as with drugs affecting the smooth muscle (1 adolescent was too hostile to accept treatment). Because the bladder was dysfunctional, the operations either failed or sequelae persisted until measures such as suggestion, hypnotherapy and retraining reversed the incoordination of micturition. Operation or reoperation in 5 children might not have been necessary if bladder coordination had been established earlier. The case of boys with poor urinary control but free of neurologic stigmas are suspect. If they require an operation for repair of congenital urinary defects such as reflux, equal attention must be paid to psychologic and habit patterns causing bladder dysfunction. Otherwise, the operation is done essentially into a neurogenic bladder. It is concluded that psychologically conditioned incoordination of voiding may alone produce mid and upper tract damage. The cases of boys with problems of urinary control not explained by neurologic or anatomic defects should be suspected and corrective surgical procedures may fail if bladder dysfunction is not corrected by retraining, suggestion and even hypnotherapy.

Child↗

Male incontinence: relationship of physiology to surgery.

After prostatectomy it is the passive continence mechanism that maintains continence. Since this mechanism is less effective when the structures are not in the normal elevated position, perineal continence operations are probably successful in proportion to the mobility of the sub-prostatic structures and the ability to keep them elevated.

Humans↗

The antibacterial effect of the bladder surface: an electron microscopic study.

To explore an intrinsic bladder defense mechanism we examined interaction between Escherichia coli and bacterial size particles (polystyrene latex balls) and the vesical luminal surface by scanning and transmission electron microscopy. The bacteria and the latex spheres were held in folds of the cellular luminal surface. Voiding (bladder contraction) resulted in the entrapment of a large number of bacteria and particles by these microplicae, with their apparent engulfment in vesicles below the cell surface. Some urine was probably contained in the folds and vesicles, thus reducing the volume of residual urine in the bladder. Since leukocytes were rarely seen in the model studied they presumably do not play an immediate role against acute infection in the normal bladder. These observations indicate that fixation of bacteria to the mucosa is 1 step in the mechanism whereby the normally functioning bladder resists infection.

Animals↗

Meatal recolonization in bitches.

Colonization of the urethrovaginal area precedes urinary tract infection in women. Among the potential factors limiting colonization by fecal pathogens is bacterial interference, the ability of established commensals to inhibit colonization by pathogenic bacteria. Since the microcontour of the canine distal urethra possesses microvilli like those in the vagina rather than the microplicae found at higher levels and also has similarities in cellular glycogen content the meatal area would be expected to respond to hormonal influences like the vagina. The normal canine urethrovaginal flora was determined by serial cultures. It consisted principally of Staphylococcus epidermidis, Corynebacterium and Acinetobacter-Haemophilus. Estrus produced a selective overgrowth of beta-Streptococcus and Acinetobacter-Haemophilus. A normal canine transient, Escherichia coli, and a normal resident, Corynebacterium, persisted only for a short time (4.5 days) unless inoculated during estrus, when they remained for a mean period of 70 days. In contrast, human Escherichia coli and Pseudomonas persisted only a short time, whether during anestrus (4.8 days) or during estrus (8.5 days). The commensals had returned fully by 14 days after sterilization, while those in estrus overresponded. Thus, indigenous bacteria inhibit establishment of certain foreign species in the urethra and hormones enhance the susceptibility to colonization.

Acinetobacter↗

Structure and function of the rabbit bladder altered by chronic obstruction or cystitis.

Decreased muscle contractility has been observed in association with intercellular collagen deposition after acute urinary obstruction. Chronically induced (2 months) bladder neck obstruction in rabbits produced similar marked changes in the ultrastructure of the bladder wall, with widening of the intercellular spaces and formation of collagen. Resting intravesical pressure was greater in animals with bladder neck obstruction than in the controls, yet response to stimulation was not impaired. Bacterial cystitis, in contrast, produced no consistent change in ultrastructure but the response of intravesical pressure to pelvic nerve stimulation was reduced. It is concluded that intercellular collagen deposition is not responsible per se for impaired conduction of nerve stimuli; perhaps discrete conduction pathways exist in the detrusor and the intercellular electrotonic spread of action potentials is not essential for contraction.

Animals↗