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Biomedical subjects

F Herzog

Publications and source records attributed to F Herzog.

At least 19 recordsLinked to original sources

Mixed biodiversity benefits of agri-environment schemes in five European countries.

Agri-environment schemes are an increasingly important tool for the maintenance and restoration of farmland biodiversity in Europe but their ecological effects are poorly known. Scheme design is partly based on non-ecological considerations and poses important restrictions on evaluation studies. We describe a robust approach to evaluate agri-environment schemes and use it to evaluate the biodiversity effects of agri-environment schemes in five European countries. We compared species density of vascular plants, birds, bees, grasshoppers and crickets, and spiders on 202 paired fields, one with an agri-environment scheme, the other conventionally managed. In all countries, agri-environment schemes had marginal to moderately positive effects on biodiversity. However, uncommon species benefited in only two of five countries and species listed in Red Data Books rarely benefited from agri-environment schemes. Scheme objectives may need to differentiate between biodiversity of common species that can be enhanced with relatively simple modifications in farming practices and diversity or abundance of endangered species which require more elaborate conservation measures.

Agriculture↗

Landscape metrics for assessment of landscape destruction and rehabilitation.

This investigation tested the usefulness of geometry-based landscape metrics for monitoring landscapes in a heavily disturbed environment. Research was carried out in a 75 sq km study area in Saxony, eastern Germany, where the landscape has been affected by surface mining and agricultural intensification. Landscape metrics were calculated from digital maps (1912, 1944, 1973, 1989) for the entire study area and for subregions (river valleys, plains), which were defined using the original geology and topography of the region. Correlation and factor analyses were used to select a set of landscape metrics suitable for landscape monitoring. Little land-use change occurred in the first half of the century, but political decisions and technological developments led to considerable change later. Metrics showed a similar pattern with almost no change between 1912 and 1944, but dramatic changes after 1944. Nonparametric statistical methods were used to test whether metrics differed between river valleys and plains. Significant differences in the metrics for these regions were found in the early maps (1912, 1944), but these differences were not significant in 1973 or 1989. These findings indicate that anthropogenic influences created a more home geneous landscape.

Animals↗

Supplementing land-use statistics with landscape metrics: some methodological considerations.

Landscape monitoring usually relies on land-use statistics which reflect the share of land-sue/land cover types. In order to understand the functioning of landscapes, landscape pattern must be considered as well. Indicators which address the spatial configuration of landscapes are therefore needed. The suitability of landscape metrics, which are computed from the type, geometry and arrangement of patches, is examined. Two case studies in a surface mining region show that landscape metrics capture landscape structure but are highly dependent on the data model and on the methods of data analysis. For landscape metrics to become part of policy-relevant sets of environmental indicators, standardised procedures for their computation from remote sensing images must be developed.

Agriculture↗

Chronic liver disease in children on long-term parenteral nutrition.

Use of long-term total parenteral nutrition (TPN) is often presumed to be associated with serious hepatic dysfunction. In this retrospective study, we reviewed the complete charts of patients who had received TPN for more than 2.5 years, starting in infancy or childhood, for evidence of liver dysfunction. There were 16 male and 10 female patients with a total of 254.5 patient years on TPN. Seventeen patients have been on TPN since birth or early infancy. Thirteen of 26 patients derive > or = 90% of their calorie intake from TPN. Six patients had hepatomegaly; two of them also had splenomegaly. Twenty-one patients had normal transaminases, nine have had past episodes of raised enzymes ranging from 2.5 to 7.5 times normal. Seventeen patients always had normal bilirubin levels, five had past episodes of hyperbilirubinaemia, while four patients had persistently raised bilirubin levels (range 1.5-20.7 g/dl). Alkaline phosphatase was normal for age in all patients except two. Hepatic synthetic function, as measured by albumin, pre-albumin levels and prothrombin time, was within the normal range in all patients except one. Liver biopsies were performed in eight patients. Two biopsies showed cirrhosis, one showed chronic active hepatitis (CAH) with cholestasis, two patients had fibrosis, one showed cholestasis and two biopsies were normal. One patient with cirrhosis and one with CAH were positive for hepatitis C antibody. Another asymptomatic patient was positive for hepatitis B. Only the patient with CAH had hepatic decompensation. We conclude that clinical hepatic failure is uncommon in our group of patients on long-term TPN for 2.5 years or more. Cirrhosis and fibrosis, when found, could not be solely attributed to TPN.

Adolescent↗

The large type II 70-kDa keratin of mouse epidermis is the ortholog of human keratin K2e.

The basic keratin pattern of mammalian epidermis consists of the basal keratin pair K5/K14 and the differentiation-specific keratin pair K1/K10. Distinct skin sites of the adult mouse, i.e., ear, sole of the foot, and interscale regions of tail skin, express an additional, type II 70-kilodalton (kDa) keratin without a defined new type I partner in suprabasal epidermal cells. Until now, the question whether this large keratin is specific for the mouse (or related small rodents) or whether orthologous keratins exist in other species has not yet been answered. In the present study, we have determined the full-length amino acid sequence of the 70-kDa keratin. The keratin comprises 707 amino acid residues and has a calculated molecular weight of 70,976.70 Da. From the structural point of view, the 70-kDa keratin is remarkable in that more than half of both the V1 and V2 subdomains of its non alpha-helical head and tail portions consist of different glycine-rich peptide motifs that are configured consecutively at least two times and as much as seven times in tandem. By means of sequence comparisons and phylogenetic investigations, we show that the 70-kDa keratin represents the murine ortholog of the human 65-kDa keratin K2e, whose nature as a genuine keratin has recently been demonstrated. The unusually large size difference of 5 kDa between MK2e and HK2e is due mainly to a different duplication rate of the glycine-rich peptide motifs in the respective V subdomains of the orthologous keratins. We discuss the properties of these highly specialized keratins, which in both species define locally restricted epidermal keratin phenotypes, and compare them with other orthologous keratins that belong to the basic epidermal keratin pattern.

Amino Acid Sequence↗

Nutritive value of four wild leafy vegetables in Côte d'Ivoire.

The overall composition, vitamin, carotene and mineral contents of the leaves of four wild plants (Ceiba pentandra, Grewia carpinifolia, Hibiscus congestiflorus, Triplochiton scleroxylon) used as vegetables in the traditional cuisine in Côte d'Ivoire were determined. The results are within the range of data published for domesticated leafy vegetables. The leaves revealed to be good sources of iron and calcium. Special attention is drawn to their contents of mucilages.

Ascorbic Acid↗

Effects of isolation, handling and novelty on the pituitary--adrenal response in the mouse.

Male Swiss strain mice were individually- or group-housed for four weeks. Basal corticosterone levels did not differ with the type of housing, providing no support for the suggestion that the condition of the individually-housed mouse is stressful. Plasma corticosterone levels also were determined for mice which had been either left undisturbed or exposed to new cages which differed from their home cages by varying degrees. There were elevations in mean plasma corticosterone levels corresponding to the degree of difference between the home cage and the new cage. This finding supports the suggestion that changes in 11-OHCS levels are sensitive measures of environmental changes. Mice forced to remain in novel places exhibited higher plasma corticoid concentrations than animals which were given the opportunity to move freely between familiar and novel places. Corticoid values, as well as neurophysiological and behavioral responses, suggested that the stress induced by forced exploration might be due to the fact that animals are prevented from freely regulating their exposure to novel places rather than to novelty per se.

Animals↗

[The prevention of chickenpox in high risk children. Comparison of the effectiveness of specific immunoglobulins and of defibrinated convalescent plasma. 414 cases (author's transl)].

Comparison between 157 children treated with defibrinated convalescent plasma and 257 children treated with specific immunoglobulins revealed the improved effectiveness of the latter treatment in the prevention of chickenpox. Specific Herpes Zoster-Chickenpox immunoglobulins are prepared by caprylic acid fractionation of convalescent plasma. The prevention obtained in more than 90% of cases would appear to be clinically and biologically total as shown by serological surveillance of certain children with particularly severe immune depression.

Chickenpox↗

[Preventive and therapeutic effect convalescent zona and varicella sera in high risk children (659 cases)].

Study of 659 cases treated with serum from patients convalescent after herpes zoster and chickenpox over a period of two and a half years in French hospital departments, showed the obvious effectiveness of this type of therapy which seems to be better than that of zoster specific gamma globulin used by other workers since we obtained protection against chickenpox in 90 p. cent of cases, and attenuation of chickenpox in 82 p. cent. It would seem that these results could be improved by increasing the doses used.

Chickenpox↗

Investigation of the recovery phenomenon in immunofluorescence after laser excitation.

Laser excitation was applied in two standard immunopathological indirect immunoflorescence systems in order to investigate bleaching and recovery of fluorescence intensity upon repeated illuminations. Variation of illumination times and dark periods between these showed that the recovery phenomenon is a function of both the (time times energy) product of excitation and the length of dark intervals. The value of high energy excitation in immunofluorescence in providing insight into the mechanisms of bleaching and recovery is discussed.

Antibodies, Antinuclear↗