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Biomedical subjects

F Henao

Publications and source records attributed to F Henao.

24 records · Page 2Linked to original sources

Penetrating wounds of the back and flank: analysis of 77 cases.

To determine the factors that allow early recognition of injuries to the intrathoracic and intra-abdominal organs in patients with penetrating wounds to the lower thorax and abdomen with site of entrance located in the back or flanks, we retrospectively analyzed the cases of 77 such patients. There were 65 stab wounds (85%) and 12 gunshot wounds (15%). The injuries were confined to the abdomen in 46 (60%); 39 were stab wounds and seven were gunshot wounds. The wounds were confined to the chest in 24 patients (31%) and involved both the chest and abdomen in seven cases (9%). Of the 53 abdominal wounds, 21 necessitated celiotomy; in 20 of them, an intra-abdominal organ was found injured, and one patient died (1.9%). Of the 24 injuries confined to the chest, only one patient required emergency thoracotomy due to massive hemorrhage; all 24 patients survived. All of the seven thoracoabdominal injuries, two produced by gunshot and five by stabbing, necessitated celiotomy. Most patients with gunshot wounds to the back and flanks require celiotomy, but a selective therapy can be safely used in patients with stab wounds. The rate of negative exploratory celiotomy was less than 5%; the mortality was 1.3%.

Abdominal Injuries↗

Multiple systems organ failure: is it a specific entity?

Multiple systems organ failure (MSOF) is a relatively new clinical syndrome that should be considered as a unified and identifiable clinical condition. In many ways it is a product of the technologic advances developed in the last few years to treat seriously ill patients. Failing respiratory, renal, and cardiovascular systems are the most frequently encountered combinations, with sepsis, faulty nutrition, and metabolic derangements often present. However, other systems of organs that support vital functions (eg, gastrointestinal, hepatic, neurologic, and coagulation) become additional important components of the MSOF syndrome. The etiology of this entity is multifactorial and difficult to clearly determine. The patients at risk are usually in an intensive care unit and are easy to identify. Because there is no specific treatment, prevention is of utmost importance. When MSOF occurs, correction of the obvious deficits, active support of the failing systems, and prevention of failure of other still functioning systems are the key to survival.

Acute Kidney Injury↗

Retroperitoneal hematomas of traumatic origin.

The significance of retroperitoneal hematomas of traumatic origin ranges from inconsequential to fatal. To elucidate factors determining this significance, 203 such instances were analyzed. In 27 patients in whom operation was not required, the diagnosis was established by roentgenologic studies. In 176, the diagnosis was made at celiotomy; in 67, retroperitoneal hematoma had ruptured into the abdomen and all were explored; the retroperitoneal hematoma was not disturbed in 62 because it appeared contained and not expanding. Due to the location around the pancreatoduodenal region or the strong possibility of injury to a major vessel, 39 contained retroperitoneal hematomas and were explored. Of the 39 deaths observed, 31 occurred in the patients admitted with shock. Twelve deaths were attributed to bleeding from the retroperitoneal hematoma. Retroperitoneal hematomas in patients who are in shock, who have peritoneal irritation or positive peritoneal lavage results, should undergo operation. Those retroperitoneal hematomas found to be contained and not expanding should not be opened, unless it is necessary to exclude associated injuries. Patients with retroperitoneal hematomas who are not in a state of shock and who have negative peritoneal lavage results do not need urgent operation, but require observation.

Abdomen↗

Boophilus microplus tick burdens on grazing cattle in Colombia.

This study was conducted at Carimagua Research Centre in a well-drained savanna area in the eastern plains of Colombia. The objectives were to note the effect of ecological factors on tick burdens, principally the effect of the environment given by four grasses on the seasonal variations of tick populations. Adult female tick counts were carried out on heifers grazing four pastures and tick larvae on the grass detected by cloth dragging. Tick counts were significantly higher on animals grazing Brachiaria decumbens than those grazing Andropogon gayanus, Melinis minutiflora or native pastures. Tick larvae counts on the grass showed a similar tendency. Introduced grasses and intensification of production will require greater care to control tick infestations since increases in stocking rate and ground coverage could augment tick populations.

Animals↗

Arteriography with simultaneous gastric distention to detect insulin-secreting tumors of the pancreas.

Gaseous distention of the stomach at the time of arteriography enhances the contrast of densities within the pancreatic parenchyma, resulting in excellent visualization and therefore precise preoperative localization of insulin-secreting tumors of the pancreas. This relatively simple modification of selective arteriography was used in the last three consecutive patients we have seen with insulinomas. Apparently, the presence of air in the stomach makes the "tumor blush" that results from the uptake of the contrast dye by the vessels within the insulinoma and is clearer than in selective arteriography alone. The stomach was distended at the time of selective arteriography with carbonated soft drinks in two cases and by gas-producing pills in one. In all three cases, the location of the tumor shown by arteriography coincided exactly with the operative findings. Distal pancreatectomy was required in two; enucleation of the insulinoma was possible in one. All three patients recovered from operation uneventfully and were completely relieved of symptoms.

Adenoma, Islet Cell↗

Ca2+ uptake coupled to glycogen phosphorolysis in the glycogenolytic-sarcoplasmic reticulum complex from rat skeletal muscle.

The glycogenolytic-sarcoplasmic reticulum complex from rat skeletal muscle accumulates Ca2+ upon stimulation of glycogen phosphorolysis in the absence of added ATP. It is shown that an efficient Ca2+ uptake involves the sequential action of glycogen phosphorylase, phosphoglucomutase and hexokinase, which generate low concentrations of ATP (approximately 1-2 microM) compartmentalized in the immediate vicinity of the sarcoplasmic reticulum Ca2+, Mg(2+)-ATPase (the Ca2+ pump). The Ca2+ uptake supported by glycogenolysis in this subcellular structure is strongly stimulated by micromolar concentrations of AMP, showing that the glycogen phosphorylase associated with this complex is in the dephosphorylated b form. The results point out that the flux through this compartmentalized metabolic pathway should be enhanced in physiological conditions leading to increased AMP concentrations in the sarcoplasm, such as long-lasting contractions and in ischemic muscle.

Adenosine Monophosphate↗