A 10-year-old boy with sickle cell anemia had a recurrent organic mental syndrome. On two occasions, symptoms and signs cleared promptly with exchange transfusion, and his neurologic condition was stable when the percentage of hemoglobin S was 19.4%.

Anemia, Sickle Cell↗

PubMed1980

Unrecognized Candida brain abscess in infancy: two cases and a review of the literature.

Two infants with presumed Candida species brain abscesses are presented. Six other infants with the same problem were found in a search of the literature, and some of the clinical and pathologic features of these patients are presented and discussed. All diagnoses were made post-mortem. There was frequent association with gastrointestinal pathology and subsequent surgery, and with antibiotic administration. Central nervous system signs and symptoms were not a prominent feature, and although most patients had disseminated candidiasis, one patient had an isolated macroscopic cerebral abscess.

Brain Abscess↗

PubMed1979

Phenytoin hypersensitivity: 38 cases.

To determine the frequency and severity of hypersensitivity reactions to phenytoin, we reviewed 38 cases of proven reactions. Patients were included only if no other drugs, including other anticonvulsants, were in use at the time of the reaction. Rashes were most frequent, followed by fever, lymphadenopathy, eosinophilia, abnormal liver function tests, blood dyscrasias, serum sickness, renal failure, and polymyositis. The pseudolymphoma syndrome, (fever, rash, and lymphadenopathy) occurred in nine patients. Thirty-five of the 38 reactions occurred within 2 months of the start of therapy. Phenytoin sensitivity accounted for 467 inpatient days during the 14 years of study. Early recognition of phenytoin reactions, prompt drug withdrawal, and appropriate therapeutic measures were necessary to prevent serious morbidity from phenytoin hypersensitivity.

Adolescent↗