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Biomedical subjects

F Hartveit

Publications and source records attributed to F Hartveit.

At least 55 records · Page 3Linked to original sources
PubMed1988

Cervical lesions in patients with malignant melanoma.

Koilocytes were found in the cervical epithelium in association with cervical intra-epithelial neoplasia in 8 out of 9 cases of malignant melanoma. This suggests that the cervical lesion in them was of viral origin. In 62 women with malignant melanoma but without cervical atypia there was also an excess of koilocytosis compared with controls with neither lesion. These findings point to the possibility that human papilloma virus infection may also be involved in the development of malignant melanoma, as it has been shown to be in cervical intra-epithelial neoplasia.

Cervix Uteri↗
PubMed1988

Cutaneous melanoma--season and invasion? A preliminary report.

Histological diagnosis of superficial spreading melanoma (SSM) of invasive type was found to vary significantly with season, such cases being most numerous in April-September. Cases of in situ type were evenly distributed throughout the year. This distinction has not been made previously. It suggests that different mechanisms may be involved in the development of these two lesions. The results as a whole support the theory that the development of invasive melanoma is related to periodic sun exposure, and are in keeping with the proposed role of ultraviolet radiation as a late-stage promoter. The possibility of virus-related initiation is also discussed.

Aged↗
PubMed1988

Metastatic patterns in autopsy cases of cutaneous melanoma.

Metastases from 62 skin melanomas occurred in specific organ combinations. CNS involvement was associated with lack of local cutaneous or lymphogenous spread and absence of metastases in lungs, liver and bones. Two predominant patient clusters were observed, one visceral with wide dissemination, and one CNS cluster with cerebral spread but few other metastases. Survival tended to be longer in the CNS cluster, and also depended on age, clinical stage, histologic type and final number of metastases per patient in the total material. It is concluded that dissemination occurs in certain specific patterns with different biological behavior.

Adult↗
PubMed1988

Metastatic melanoma of unknown origin at autopsy.

In 93 patients dying from metastatic melanoma the primary tumor was unknown in 13 (14%) after autopsy. There were no significant differences compared to cutaneous melanoma with respect to sex, age, organ distribution of metastases or final tumor load. An unknown primary was, however, significantly more common in cases presenting with general metastases compared to regional spread. The causes of death were similar to cutaneous cases. Our data suggest that melanoma of unknown origin has the same predilection and biology as metastatic cutaneous melanoma, supporting the view that regression of a cutaneous primary may be involved.

Aged↗
PubMed1988

Differences in the occurrence and age distribution of lesions in other organs in women with/without cervical neoplasia.

Over a 5 1/2 yr study period lesions leading to biopsy were reported in 902 of 3.937 women (23%) with a record of cervical neoplasia, compared to 1,142 of 13,030 controls (9%). This applied irrespective of the severity of the cervical lesion. In women with a record of cervical neoplasia, again irrespective of the severity of the lesion, relatively more lesions were seen in other organs in the younger age groups (45 yrs and less). In contrast the number of such lesions increased with age in the controls. While the present study gives no indication of the possible nature of the implied link between cervical neoplasia and the other lesions involved, it is suggested that the possibility of a common virus aetiology should be explored.

Adolescent↗
PubMed1987

Changes in autopsy profile--1975 and 1984.

In 1975 diseases of the circulatory system were the major cause of death in our hospital autopsies, with neoplasia a poor second. In 1984 the situation was the reverse. The reduction in diseases of the circulatory system was due mainly to that in cerebrovascular cases, deaths from coronary artery disease being unchanged. The increase in neoplasia affected older women in particular, who died from less common types of cancer. It is suggested that these patients may have escaped death from cerebrovascular disease and avoided cancers that usually kill in middle age, to die later of other age-related types that were less common in 1975. The present findings emphasize the importance of recognizing and adjusting to a changing spectrum of disease that is developing in the ageing population found in a West European country.

Adult↗
PubMed1987

Size of breast carcinomas at operation related to tumour growth rate.

The mean nuclear area (MNA) of breast carcinoma cells, previously shown to be related to prognosis, is here presented as a potential overall measure of tumour growth rate prior to operation. Recording of tumour diameter and MNA in 340 infiltrating breast carcinomas demonstrated that tumours of low MNA tended to present at a lower diameter that those of high MNA. The former have thus remained 'small' over a longer period, giving the woman more time to report them at this stage. It is suggested that mass screening from breast carcinoma may pick up these slow growing tumours, missing those of high growth rate unless the screening interval is correspondingly short.

Breast Neoplasms↗
PubMed1987

Stromal metachromasia: a marker for areas of incipient invasion in ductal carcinoma of the breast?

This morphological study of small ducts with in situ breast carcinoma demonstrates the changes that occur in the adjacent stroma when it stains metachromatically with toluidine blue. They are indistinguishable from those reported in areas with infiltrative tumour growth, and are accompanied by progressive damage to the duct wall. The latter may be destroyed as a result of this reaction that starts in the stroma, the tumour cells being thus provided with a possible means of escape from their in situ localization. This interpretation is in contrast to accepted teaching that the factors that facilitate infiltration are provided by the tumor cells. The observation is also of potential diagnostic interest.

Breast Neoplasms↗
PubMed1987

Malignant melanoma of the skin. Changing clinical stage at presentation, 1955-1979.

The rising incidence of malignant melanoma is associated with a change in the stage at presentation. As a result more deaths can now be expected in stage I patients, despite their overall better prognosis. More accurate staging, with regional node dissection, is needed if these 'at risk' patients are to be identified earlier. This need will become more acute as suitable adjuvant chemotherapy and other regimes become available.

Female↗
PubMed1987

Metastatic distribution in malignant melanoma. A 30-year autopsy study.

The metastatic pattern is described in 75 cases of malignant melanoma coming to autopsy over a 30-year period. Skin primaries were identified in 62 of them. Males outnumbered females in this, as in other autopsy studies. Metastases to lungs, liver and bone were interrelated and associated with further dissemination. Cerebral metastases occurred more often in initially localized lesions and were associated with few other metastases. It is stressed that detailed examination of the brain at autopsy is needed to identify cerebral involvement, and that brain scans may be indicated particularly in patients with seemingly localized primaries to identify latent cerebral involvement.

Age Factors↗
PubMed1986

Risk of carcinoma following gastric operations for benign disease. A historical cohort study of 3470 patients.

The risk of stomach cancer was analysed in a cohort of 3470 patients who had had gastric surgery for benign disease between 1900 and 1969. In 87 patients (2.2%) stomach-stump cancer was diagnosed in the follow-up period 1970-84. By comparison with the total incidence of stomach cancer in the same region during the same time period, the observed versus expected ratio in the post-surgery group was 2.1 (p less than 0.001) and did not differ between men and women. At 5-10 years postoperative the risk of cancer was no different from that in the total population, whereas after 40-45 years it was 7.3-fold higher. The risk was unrelated to primary diagnosis or type of operation.

Adult↗
PubMed1986

Haematogenous metastatic patterns in colonic carcinoma: an analysis of 1541 necropsies.

The sequence of events in haematogenous metastasis from colonic carcinoma was analysed, using 1541 necropsy reports from 16 centres. The findings are consistent with the cascade hypothesis that metastases develop in discrete steps, first in the liver, next in the lungs and finally, in other sites. Deviations of necropsy findings from the cascade model are largely explained on the basis of false negative reports. In only 216 of 1194 cases was there suggestive evidence that metastatic patterns (excluding lymph nodes) were causally related to lymphatic or non-haematogenous pathways. The incidence of metastatic involvement in 'other' (quaternary) sites correlated with target organ blood-flow (ml min-) per g, only when bone marrow and thyroid were excluded. In the thyroid the incidence was lower than expected on the basis of blood flow per g tissue; this may indicate that the thyroid is an unfavourable site for metastatic growth of colonic carcinoma. In the bone marrow it is higher; the latter may be due to delivery of cancer cells via both arterial blood and the vertebral venous plexus. Recognition of this pattern of metastases in the bone marrow could be important with respect of diagnosis and therapy, in patients with colonic carcinoma.

Aged↗
PubMed1985

Fiber concentration in lung tissue of patients with malignant mesothelioma. A case-control study.

The risk of malignant mesothelioma associated with low-level asbestos exposure is an important unresolved issue today. We have analyzed the asbestos fiber concentration in lung tissue from 14 cases of malignant mesothelioma and 28 case-matched controls by scanning electron microscopy. The cases represent 86% of all mesotheliomas recorded by the Cancer Registry of Norway from the county of Hordaland between 1970 and 1979. Based on 1 million fibers per g of dried tissue as an indicator of cumulated asbestos exposure, the odds ratio (relative risk) was 8.5 (95% confidence limits, 2.3-31.1). Assuming that the risk of malignant mesothelioma is related to mineral fiber concentration in lung tissue, it is concluded that a fiber concentration exceeding 1 million fibers per g of dried tissue is associated with an increased risk of malignant mesothelioma. Furthermore, the results are consistent with a no-threshold response.

Adult↗
PubMed1985

On the reputed decline in gastric carcinoma: necropsy study from western Norway.

Carcinoma of the stomach is said to be decreasing in many countries, Norway included. About 10% of all cases in Norway occur in the county of Hordaland. They do not differ in any known respect from cases in the rest of the country. A series of 575 cases coming to necropsy from Hordaland over 25 years was examined and the findings compared with the total number reported to the Norwegian Cancer Registry from the same district. Although the incidence of histological verification rose over the period from 49 to 85%, the number of histologically confirmed cases remained relatively constant, the considerable decline being confined to cases without such documentation. The results suggest that increased diagnostic effort has led to the exclusion of cases previously classified clinically as gastric carcinoma and that the incidence of the disease itself has not changed radically in the county of Hordaland.

Adult↗
PubMed1985

Quantitation of the axillary lymphoid tissue in women without cancer.

The number and distribution of nodes in the axilla of non-cancer autopsy patients was similar in women over and under 75 years of age, but the total area of nodal tissue was greater in the latter, suggesting a possible decrease in immune reactivity with age. Fewer nodes were found than have been reported in breast cancer patients examined by the same method. This is probably due to increase in size of sub-macroscopic nodelets on stimulation.

Age Factors↗
PubMed1985

Time-dependent changes in the axillary nodes in breast cancer: nodal area.

This paper reports a difference in the lymphoid tissue area in the axilla of node-negative breast cancer patients in the first versus the second half of the year, the area being greater in the latter. This observations is new. It is based on data from 72 patients derived over 25 consecutive months and is in keeping with previous reports of a proliferative histological picture in the nodes at this time. The findings were less marked in the node-positive cases (23), and were not accompanied by an increase in nodal number. No such difference was seen in 80 specimens from noncancer autopsy controls. A total of 1,868 nodes were evaluated. The possibility that light-mediated reactions may be involved is discussed briefly, as is the role of this proliferative reaction and its probable mediation relative to the parallel histological changes reported in primary breast carcinomas at this time.

Adult↗
PubMed1984

Prognostic evaluation in node-positive breast carcinoma: stage versus growth rate.

The range in survival time in operable node-positive breast carcinoma is considerable. Postoperative management is thus dependent on accurate prognostic assessment. This involves the choice of relevant prognostic factors. Theoretically these should include measurements of both stage and growth rate. In a series of 96 cases it is demonstrated that the diameter of the primary (3 cm and under/over 3 cm) can be used as a measure of tumour stage; the histological grade of the primary as one of tumour growth rate; and the presence/absence of tumour cells in the efferent nodal vessels (EVI status) as a measure of nodal stage. The latter is proposed as an alternative to the number of tumour-bearing nodes recovered from the axilla. Division of the cases on this basis was sufficient to assess high or low risk using routine histological methods.

Axilla↗