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Biomedical subjects

F Hartmann

Publications and source records attributed to F Hartmann.

At least 127 records · Page 7Linked to original sources
PubMed1987

[Isolated perfusion of the small intestine of the rat with perfluorotributylamine as an artificial oxygen carrier].

A new model of isolated intestinal perfusion could be established with fluorocarbon (FC-43) as artificial oxygen carrier. Morphology, cell metabolism of xenobiotics (phase I and II), as well as the transport of a monosaccharide, were stable for at least 2 h. Without interference with the changing metabolism of erythrocytes in the perfusion medium, the proposed model allows one to investigate exclusively the metabolic function of the perfused organ.

Animals↗
PubMed1986

Biomechanical properties of human intervertebral discs subjected to axial dynamic compression--influence of age and degeneration.

This investigation was performed to study biomechanical properties of human intervertebral discs as a function of age. 178 specimens from 21 spinal sections (Th9-S1, 5-84 yr) were subjected to axial dynamic compression; the load being 950 +/- 540 N. The results revealed three distinct age ranges: From the first to the middle of the third decade: axial deformability decreases within the thoracic region, and remains almost constant within the lumbar spine; creep decreases in both parts. From the middle of the third to the beginning of the sixth decade: the biomechanical behavior scarcely alters. Afterwards: axial deformability remains unchanged; creep, however, again increases within the lumbar spine. The results reveal the discs behave most efficiently within the age range where the incidence of back pain is maximal.

Adolescent↗
PubMed1986

Activation of latent collagenase from polymorphonuclear leukocytes by oxygen radicals.

Polymorphonuclear leukocytes (PMN) accumulating at inflammatory sites have the potential to degrade collagen by releasing the metalloproteinase collagenase (EC 3.4.24.7), which is stored within the specific granules of these cells in a latent, inactive, form. In order to elucidate the activation mechanism the latent enzyme (molecular weight 91,000) was purified from human PMN and incubated with the oxygen radical-generating system of xanthine oxidase (EC 1.1.3.22) and hypoxanthine. This coincubation resulted in the activation of the latent enzyme as assessed by the collagenolytic attack on human and bovine cartilaginous tissue. Two parameters for collagenolysis were used: loss of hydroxyproline-containing fragments, and mechanical measurements reflecting the stability of tissue specimens. Superoxide dismutase (EC 1.15.1.1) as well as catalase (EC 1.11.1.6) were capable of inhibiting the activation of latent PMN collagenase by the oxygen radical-generating system. The results indicate the hydroxyl radical to be the final oxidant responsible for the activation of latent PMN collagenase. Thus a new activation mechanism of latent collagenase is presented in this paper and discussed together with the potential relevance in pathophysiologic states of acute and chronic inflammation.

Animals↗
PubMed1985

[Not Available].

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History, Modern 1601-↗
PubMed1985

[Apropos of a case of sleep hypochondriasis].

About one case of an important sleeplessness for 4 years, the authors show the characteristics of this moan, which they would want to call it "Sleeping hypochondria". This hypochondria is very "efficient" because the sleeping quality is always subjective. More, patient and therapeut especially invest it. Oftenly, hypnotics are ordained. In this case, the confusion between offered and real symptoms could be grown. In fact, the last one is the patient moan, his speech subject. The treatment of this particular case, by paradoxical injunction, allowed to create a breaking of the patient system. The paradoxical cure, by made-self prescription, allows to understand much better the "insomnia work" in the aggressive relationship with the therapeut.

Adult↗
PubMed1984

Mitoxantrone metabolism in the isolated perfused rat liver.

The hepatobiliary pharmacokinetics of mitoxantrone, a new anthracenedione derivative, was studied in the isolated perfused rat liver. Mitoxantrone was administered in doses of 0.2 and 0.4 mg/kg body weight. Multiple bile samples were obtained for 4 hours. Mitoxantrone and three metabolites were separated by high-performance thin-layer chromatography (HPTLC) and measured at 610 nm. Following 0.2 mg mitoxantrone/kg body wt, 25.8% +/- 2.6% of the administered dose was excreted in the bile during 4 h, the major metabolite M1 accounting for 80% of this. After 0.4 mg mitoxantrone/kg body wt the amounts excreted were lower and light microscopic examination showed disseminated areas of cell necrosis.

Animals↗
PubMed1984

The corporeality of shame: Px and Hx at the bedside.

In order to appreciate the role of the phenomenon of shame in the context of the clinic - both as normal self evaluation and as neurotic response - a philosophical anthropological description of shame is offered. Not only are Biblical metaphors recast , but more recent phenomenological psychological descriptions taken from Max Scheler and others are cited. These necessarily require some account of the patient's body in shame, taken from both his perspective and the physician's. In short, the corporeality of shame is constituted as "ce que enveloppe le corps".

Guilt↗
PubMed1984

Biomechanical properties of human intervertebral discs subjected to axial dynamic compression. A comparison of lumbar and thoracic discs.

This investigation revealed biomechanical properties and some morphological parameters of isolated intervertebral discs at various disc levels. One hundred twenty-three specimens were subjected to axial dynamic compressive loads. The duration of testing was 5 minutes, the loads Fd1 = 650 N +/- 400 N (discs from T5-6 to L1-2) and Fd2 = 950 N +/- 540 N (discs from T9-10 to L5-S1). Down the spine, the mean disc heights and cross-sectional areas increased; the water content seemed to be nearly constant. Axial deformation and ventral bulging increased down the spine as well, which is mainly due to the increasing disc height. Creep showed different characteristics. It was smallest within the region T10-11 to L1-2 and increased above and below this level. The increase below L1-2 is mainly due to the increasing disc height; the increase above T10-11 occurs because the thoracic discs behave in a more viscous manner than the lumbar discs.

Adolescent↗