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Biomedical subjects

F Harder

Publications and source records attributed to F Harder.

At least 289 records · Page 16Linked to original sources
PubMed1983

[Therapeutic breast-preserving measures in operable breast carcinoma].

Simple mastectomy with axillary clearance represents the standard therapy in operable breast cancer. In many cases no additional complex therapeutic measures have to be taken. For small tumors without clinical suspicion of lymphnode involvement in the axilla a combination of tumorectomy and axillary clearance followed by high voltage radiotherapy allows the conservation of a nearly normal breast. The survival figures available today show no difference between amputation and conservative treatment. An absolute condition for successful conservative treatment and follow-up is a consequent and continuous collaboration between the involved disciplines. If this is not the case, mastectomy with eventual later reconstruction has to be preferred.

Breast Neoplasms↗
PubMed1982

[Clinical relevance of N-acetylglucosaminidase determination in urine of kidney transplant recipients with and without cyclosporin A].

From January to September 1981 urinary gamma-N-acetyl-glucosaminidase (NAG) excretion was measured in 23 cadaver kidney recipients up to 90 days posttransplant. Conventional immunosuppression with azathioprine and prednisone was used in 12 patients, and cyclosporin A (CyA) in 11 patients. The purpose of this study was to assess the clinical value of NAG determinations in the diagnosis of acute rejection episodes and CyA-induced nephrotoxicity. A total of 26 acute rejection episodes were observed. 14 (54%) of these were associated with a significant increase in NAG excretion. The other 46 episodes of increased NAG excretion (77% of a total of 60 episodes) were unrelated to acute rejection reactions. No obvious reason was apparent in 39 instances (63%). Nine out of 11 patients treated with CyA showed one or more increases in NAG excretion, but the number of such episodes did not differ between patients with CyA serum concentrations below 500 ng/ml and those with levels above 500 ng/ml. Histological signs of CyA toxicity in graft biopsies correlated well with increased NAG excretion. It is concluded that increases in NAG excretion are not sensitive and specific enough to be of definite help in the diagnosis of acute rejection and/or CyA-induced nephrotoxicity.

Acetylglucosaminidase↗
PubMed1982

Acute gallstone pancreatitis: best timing for biliary surgery.

The timing of biliary surgery in patients who have pancreatitis secondary to cholelithiasis is debatable. Of 523 patients admitted for acute pancreatitis between 1969 and 1978, 114 had gallstones for which an operation was performed, early and late operation respectively in 98 patients. Complications occurred in 12 of the 114 patients and 7 patients died. Significantly more deaths occurred in the group who had an immediate operation (n = 5). In the group who had an operation more than 7 days after the amylase returned to normal, recurrent pancreatitis developed in 5 patients, 1 of whom died. It is concluded that immediate operation does increase mortality, and so may delay longer than 7 days after the amylase returned to normal.

Acute Disease↗
PubMed1982

Femoral nerve lesion subsequent to renal transplantation.

Severe femoral neuropathy subsequent to renal transplantation is described in a patient who died in the 5th postoperative week. Postmortem examination revealed a compression of the femoral nerve by an older hematoma of the iliac muscle, ipsilateral to the transplantation, and severe Wallerian degeneration of the nerve beginning at the site of the hematoma. It is postulated that the hematoma resulted from surgical trauma on the iliac muscle and was facilitated by previous anticoagulation and hypertensive vasculopathy. We suggest that every patient with similar symptoms occurring after renal transplantation should be investigated for a retroperitoneal hematoma. If such a hematoma is diagnosed, immediate decompression neurolysis should be performed in order to prevent prolonged recovery time or permanent disability.

Femoral Nerve↗
PubMed1981

Normal keratinized mucosa transplants in nude mice.

Two types of normal keratinized mucosa were transplanted to subcutaneous sites of nude mice of two different strains. 24 intact specimens of clinically normal human palatal mucosa were transplanted to nude mice of the strain nu/nu NC. The transplants were recovered after 42 d with a recovery rate of 96%. Moreover, 22 intact specimens of normal rat forestomach mucosa were transplanted to nude mice of the strain nu/nu BALB/c/BOM. These transplants were recovered after 21 d with a recovery rate of 63%. The histologic features of the transplants were essentially the same as those of the original tissues. However, epithelial outgrowths from the transplants differed with respect to the pattern of keratinization. The outgrowths of human palatal mucosa transplants were essentially unkeratinized, while the outgrowths of the rat forestomach transplants showed continued keratinization.

Adolescent↗
PubMed1981

[Cadaveric kidney transplantation in patients over 55 years].

The progress of 24 patients aged over 55 who received kidney transplants from dead bodies is compared with that of 42 recipients aged under 55. The functioning of the transplants and mortality do not differ in the two groups 3 and 12 months after transplantation. However, in the group of older transplant patients we found a high incidence of analgesic nephropathies, twice as many associated cardiac complications and an increased incidence of tumours. It seems no longer justifiable to withhold such kidney transplants from patients over 55 on grounds of age.

Adult↗