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Biomedical subjects

F Harder

Publications and source records attributed to F Harder.

At least 253 records · Page 14Linked to original sources
PubMed1985

[Catheter jejunostomy in elective abdominal surgery].

Needle catheter jejunostomy is used to a varying extent today. Therefore, the need for nutritional support was evaluated following elective abdominal surgery and compared to experiences with postoperative enteral feeding. Oesophagectomy, total gastrectomy and the Whipple procedure were identified as good indications for catheter jejunostomy, whereas with other types of operation an individual decision is required.

Catheters, Indwelling↗
PubMed1984

[Tumors and kidney transplantation].

Incidence and type of de novo tumours were studied retrospectively in 187 consecutive patients who had received kidney transplants between 1967 and 1981 and undergone immunosuppressive therapy for 2 months or longer. Up to the end of June 1983, 18 patients (9.6%) had developed 22 malignancies and 7 of them had died from the tumour. The risk of developing a malignancy appeared to increase with prolonged immunosuppression. No significant difference was noted between patients with and without tumours regarding primary renal disease, duration of pretransplant dialysis, and type or total dose of immunosuppressive drugs. The risk of developing any malignancy appeared to be some 20 times that in the general population. The practical management of patients with de novo tumours is described in the light of our own patient material and the recent literature. Finally, two further oncological problems are discussed: first, the incidental grafting of malignant cells with the transplant, and second, how to proceed in a transplant candidate with a previous malignancy.

Adult↗
PubMed1984

Identification of human connective tissue in transplant of human oral mucosa in nude mice.

The present study describes a method for identification of connective tissue of human oral mucosal transplants in nude mice. The method was based on the development of a murine antiserum to human fibroblasts. After absorption with murine fibroblasts the antiserum in an immunofluorescence method appeared to react specifically with human connective tissue of frozen sections, whereas the antiserum did not react with murine connective tissue. The antiserum, applied to frozen sections of human oral mucosal transplants in nude mice, could distinguish between human and murine connective tissue in the sections. The ability to distinguish between the two types of tissue was utilized to elucidate a possible relation between epithelial morphology and underlying type of connective tissue. It was found that the formation of rete ridges of transplanted human oral epithelium was dependent on the presence of subepithelial human connective tissue. The method described may be useful for the recognition of human tissue in experimental studies of human transplants to other species.

Adolescent↗
PubMed1984

The junction zone of human epithelium and foreign stroma. Ultrastructural observations in human oral mucosal transplants in nude mice.

This study describes ultrastructural features of epithelial-stromal junction of human buccal and palatal mucosal transplants and their outgrowths in nude mice. The investigation included transplant epithelium overlying human connective tissue in 27 cases, epithelial outgrowth formed over murine connective tissue in 33 cases, and over Millipore filter in 12 cases. The epithelial-stromal junction of the transplants differed from the normal state only in the presence of lamina densa loops projecting into the connective tissue and in lamina densa interruptions and duplications. In contrast the epithelial outgrowths demonstrated flattening of epithelial basal cells, lack of proximal epithelial cell projections, lack of complete hemidesmosome complexes, lack of distinct lamina densa, and lack of anchoring fibrils. It is suggested that these changes may be due to lack of necessary interaction between the human epithelium and the foreign stroma.

Adolescent↗
PubMed1984

Cyclosporine alone or in combination with prednisone in cadaveric renal transplantation.

One hundred recipients of first cadaveric kidney transplants were treated with three different immunosuppressive regimens: (1) conventional immunosuppression, (2) CsA alone, and (3) low-dose CsA in combination with low-dose prednisone, with rapid adjustment to give CsA whole blood trough levels of 300 to 800 ng/mL. One-year graft survival in the aza + pred group was 76%, and in the CsA alone group 75%. Graft survival at two and six months in the CsA-pred group was 94%. The dose of CsA in the CsA-pred group in the first two months posttransplant was only about half that given to the CsA-alone group. Surprisingly, the reduction in the CsA dose also reduced the number of methylprednisolone pulses given for treating rejection by greater than 50%. The incidence of nephrotoxicity and extrarenal side effects also fell considerably. Withdrawal of prednisone in the CsA-pred group after five months led to reversible rejection in two cases. In conclusion, (1) the rapid reduction in the CsA dosage is beneficial and has no drawbacks, and (2) our guidelines for withdrawing prednisone (timing of withdrawal, rate of reduction in dosage) still need further refinement.

Adult↗