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Biomedical subjects

F Hanyu

Publications and source records attributed to F Hanyu.

81 records · Page 5Linked to original sources
PubMedDate not supplied

Esophageal squamous cell carcinoma: pathology and prognosis.

Between 1985 and 1992 a total of 403 patients with resected thoracic esophageal squamous cell carcinoma were evaluated histopathologically, and various pathologic findings related to survival were examined. Concerning depth of tumor invasion, 8 (2%) cases were pTis, 110 (27%) were pT1, 48 (12%) were pT2, 202 (50%) were pT3, and 35 (9%) were pT4. Lymphatic invasion was detected in 299 cases (74%), blood vessel invasion in 200 cases (49%), intramural metastasis in 45 (11%), and lymph node metastasis in 232 (58%). In pT1 carcinoma cases, 4% of mucosal carcinomas and 30% of submucosal carcinomas had lymph node metastasis. Tumors with deeper invasion had a higher incidence of lymph node metastasis: 74% of pT3 carcinomas and 83% of pT4 carcinomas. The sites of lymph node metastasis were divided into mediastinal, cervical, and abdominal fields; and rates of lymph node metastasis were 49%, 14%, and 41%, respectively. In all resected cases, the operative mortality rate was 3.2%, and the overall 5-year survival rate was 44.8%. The 5-year survival rate of patients with curative resection (R0 and R1) was 49.5%, whereas patients with palliative resection (R2) did not survive more than 3 years. There was no significant difference in survival relative to tumor location. In curatively resected cases, the significant prognostic factors by multivariate analysis were pT category, vascular invasion, lymph node metastasis, and intramural metastasis. Prognosis of lymph node-positive cases did not depend on the positive node site. Patients with only one positive node had a better prognosis, and those with six or more positive nodes had a poor prognosis.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

Induction and clinical utilization of lymphokine-activated killer cells in patients with gastrointestinal tract cancers.

In 18 patients with cancers of the gastrointestinal tract, lymphokine-activated killer (LAK) cell activity was studied and compared with that of healthy subjects. After cultivation with 10(3) iu/mL of recombinant interleukin-2, the cytotoxicity of patients' lymphoid cells was increased from 13.6 +/- 6.8% to 76.2 +/- 19.5% against Daudi cells and from 12.8 +/- 8.1% to 76.2 +/- 19.5% against K-562 cells. Based on these results, autologous LAK cells were given to patients. LAK cells injected into subdermal metastatic tumours demonstrated a significant inhibitory effect on tumour growth in comparison with that of control tumour nodules. Of four patients with metastatic tumours in the liver, to whom LAK cells were administered via the hepatic artery, tumour size was reduced by about 25% (minor response) in one patient, with a decrease of computerized tomography attenuation in the tumours occurring in the other three patients.

Adult↗
PubMedDate not supplied

Highly anatomically systematized hepatic resection with Glissonean sheath code transection at the hepatic hilus.

We have developed a new method of hepatic resection, in which the cancer-bearing Glissonean code (G-code) branches are served using a hilar approach for an anatomically systematized resection. Since the hepatic artery, portal vein and bile duct are surrounded by connective tissue, the portal triad can be treated as a fibroid code both outside and inside the liver. Compared to the ramification pattern of the hepatic artery, portal vein and bile duct, that of the G-code is simpler. In all our surgical procedures of hepatic resections, the cancer bearing G-code branch is selectively cut using a hilar approach before the dissection of the parenchyma of the liver. We have experienced 168 cases of several types of hepatic resection for hepatocellular carcinoma. Only in three cases was it impossible to accomplish the transection of some third branches using a hilar approach.

Bile Ducts↗
PubMedDate not supplied

Technique and management of percutaneous transhepatic cholangial drainage for treating an obstructive jaundice.

BACKGROUND/AIM: The authors report on the experience they have gained with regard to the techniques and management of percutaneous transhepatic cholangial drainage (PTCD) as a non-operative method for providing biliary drainage in treating 1,012 patients with obstructive jaundice. MATERIALS AND METHODS: The PTCD puncture for drainage was performed under fluoroscopic guidance for 603 patients between January 1968 and October, 1980, and under ultrasonic guidance for 409 patients between August, 1978 and July, 1994. RESULTS: The incidence of complications after the fluoroscopically-guided puncture was 6.0%, the early post-PTCD complications consisting of hemobilia(5 patients), shock due to an increased the intrabiliary pressure following an injection from the contrast material (12 patients), and shock due to a decrease in the intrabiliary pressure (13 patients), and the late complications consisting of bile peritonitis caused by catheter displacement (6 patients). In contrast, the incidence of post-PTCD complications after the ultrasonically-guided puncture amounted to only 0.7%, which was dramatically lower, and the only complication that occurred was a late complication due to PTCD-tube displacement. CONCLUSION: Thus, monitoring the PTCD-tube is important to complete recovery from the PTCD procedure.

Cholestasis↗
PubMedDate not supplied

Right side hepatic resection under right thoracoabdominal incision with special reference to a highly anatomical systematized method.

The results of 31 right side hepatic resections approached through thoracoabdominal incision are described, with emphasis on the benefit of the approach and systematized liver resection. Regarding postoperative mortality rate (0%) and morbidity rate (32.3%), the thoracoabdominal approach for right side hepatic resection seemed as safe and effective as the conventional abdominal approach. Even though there were no significant differences in the complications, the fluctuation of alanine aminotransferase and the hospital stay, the average operation time for the right segmentectomy through the thoracoabdominal approach was 1.3 hours less (p = 0.0078) than that of the abdominal approach. Technically, this approach was accomplished in almost the same fashion as in the abdominal approach by the utilization of systematized hepatic resection. Thoracotomy itself was not more harmful than the abdominal approach, even in patients with impaired liver function. This combination could take the advantage of a shorter operation time.

Adult↗