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Biomedical subjects

F Halberg

Publications and source records attributed to F Halberg.

At least 541 records · Page 30Linked to original sources
PubMedDate not supplied

Telehygiene system for preventive chronopharmacology in space and remote areas on earth.

A chronobiologic computerized modular health care (telehygiene) system for humans in extraterrestrial space 1) monitors and analyzes physiologic blood pressure, heart rate and other variation, including that in tumor markers; 2) recognizes earliest risk elevation by dynamic changes in the 'usual value' range (trend and rhythm alteration); 3) prompts timely and timed treatment for cardiovascular and emotional disease and malignancy prevention, and 4) serves for health improvement; the information from the system can also help optimize shift-work schedules for peak performance and provides endpoints of interest in basic science. The system exploits the chronome, a genetically anchored, habitat-synchronized structure of multifrequency rhythms and trends which is now documented (by longitudinal data series) to respond to magnetic disturbance in the solar system, with consequences expressed in catastrophic illness that is best prevented. Such a system, rated by peers as being of highest priority, could complement classical tools such as the stethoscope, proposed by the U.S. Johnson Space Center representative for use on the moon.

Aerospace Medicine↗
PubMedDate not supplied

Human chronome research at the service of veterinary medicine: a legacy of Erna Halberg.

The time has come for humans to return the debt to the many non-human species that were studied for the sake of humanity and to extend the motto of "doing unto oneself first what eventually is to be done to others" when the "others" are the patients of veterinarians. As physiologic monitoring benefits from advances in hardware and software, much chronobiologic information can be obtained on the chronomes of the different species cared for by veterinarians for a new health care focusing on prevention, implemented perhaps by recognizing and treating earliest rhythm alteration rather than merely the fact of overt disease.

Animals↗
PubMedDate not supplied

Differences in some circadian patterns of cardiac arrhythmia, myocardial infarctions and other adverse vascular events.

BACKGROUND: Results from unpublished data on the incidence of adverse vascular events and from several published studies are reevaluated chronobiologically. METHODS AND RESULTS: Cosinor methods indicate 1. a circadian variation in the incidence of paroxysmal supraventricular tachycardia (PST), of broadly classified ventricular arrhythmia (VAr), and of atrial fibrillation (AF); 2. a statistically significant difference in the timing of the circadian rhythm of PST and VAr versus that of AF; and 3. a further difference in the timing of these rhythms from that in the incidence of myocardial infarctions (MI). Electrocardiographic records for spans longer than 24h show the extent of day-to-day variability in circadian characteristics of the given patient and indicate the presence of even lower-frequency components, notably along the scale of a week, that may underlie weekly and half-weekly patterns of morbidity and mortality. CONCLUSION: Beyond alterations in the about 1-Hz periodicity of the heart, predictable changes along the scales of the day and the week may constitute a clue to the etiopathology of a given condition and provide a basis for treatment timing. The assessment of unfavorable changes in the lower frequency components may provide a lead time long enough to prompt the institution of preventive, rather than curative, intervention.

Animals↗
PubMedDate not supplied

Power of 'phase 0' chronobiologic trials at different signal-to-noise ratios and sample sizes.

Clinical trials would gain from incorporating 'Phase 0' chronobiologic pilot designs both from the viewpoint of (statistical) power and cost-effectiveness. Herein, this statement is documented by power computations and is further illustrated by clinical examples answering specific questions. Power computations show the merits both of chronobiologic designs (that assign samples at equidistant intervals to cover one full cycle of anticipated pertinent rhythms) and of chronobiologic analyses (the cosinor versus the analysis of variance). Randomized clinical trials would gain from incorporating a concern for timing as well as dosing in all three stages of clinical trials (Phase I, II and III focusing on toxicity, efficacy and a comparison with the current best treatment, respectively) and could be cost-effectively preceded by 'Phase 0' trials so as to detect, sooner and with smaller sample sizes, desired or undesired effects that may otherwise be missed.

Analysis of Variance↗
PubMedDate not supplied

Clinical trials: the larger the better?

A chronobiologic approach is much more than fine-tuning that may perhaps be considered after a drug has been identified as useful; at very little cost at first, a Phase 0 chronobiologic trial may show that there is danger that a given drug may do more harm than good when administered at the wrong time. At least equally important, the chronobiologic approach may recognize the usefulness of a drug that is active only at the proper time. When different chronobiologic timing results in opposite effects from the same total weekly dose of the same drug, it is clear that timing cannot be separated from dosing. The time structure-adjusted pattern of drug administration can make the difference between the undesired stimulation of a malignant growth and shortening of survival time and the desired growth inhibition and prolongation of survival. The experience with lentinan, namely that this immunomodulating drug can stimulate as well as inhibit the development of a cancer, may apply to many more therapeutic agents in a day and age of biologic response modifiers. It is a point of particular importance that an immunostimulator ought not be given at a time when it can be an immunosuppressor. What is surprising to many under these circumstances is that chronobiologic designs are also cost-effective. Most scholars believe that if a test is carried out at six times, it will cost six times more, will require six times more patients and six times more work. We believe we have shown that the reverse holds true: if so, the discussion of the pros and cons of chronobiometry and of neglect thereof becomes one of ethics. Figures 1-5 depict the status quo. Examples have been given to show that some effects can be obtained only at certain times with the dose used. Figure 8 reveals the doubling of the desired anticancer effect by timing treatment according to an unspecific marker rhythm. The recognition of the power of chronobiologic designs coupled to the discovery of large-amplitude rhythms in non-invasively determined marker chronomes is a challenge that can be exploited, particularly in the treatment of cancer. Marker determinations are still expensive, but once the cost of their development is paid, a market is established, and the community is trained in self-help, the responsibility now assumed by most diabetic patients for themselves can also be shouldered by cancer patients.(ABSTRACT TRUNCATED AT 400 WORDS)

Biometry↗
PubMedDate not supplied

Chronobiologic perspective of international health care reform for the future of children.

The realization of the implications of splitting the atom ended a tragic war. The nuclear age ensued. Likewise, a devastating escalation of health care costs could be ended by realizing the implications of splitting the normal range. Our currently disease-cure-oriented health care system does too little too late. Chronobiology could change this status quo into a system that recognizes risk early; it would gain new information from the resolution of predictable variations that take place within the physiologic range. Investment into vaccinations leads to returns in the form of savings in suffering and cost. A relatively modest investment into a 'Blood Pressure Health Start', pursued while chronobiology is being taught as an integral part in primary, secondary, higher and continued education, may not only drastically and in some respects promptly reduce the health care bill, but it would help the economy of the country that invests into the development of instrumentation for a chronobiologic systems approach. On the one hand, reducing the number of cases of catastrophic diseases, via improved diagnosis (to start with) of the blood pressure status, is likely to substantially reduce the budget deficit by reducing the legitimate and essential costs of care (to start with, of strokes and heart attacks, that kill more people than all other diseases combined and that have blood pressure disorders as their major risk factor). On the other hand, by implementing a novel health care system which also involves new technology that can become in demand worldwide, any trade balance will be improved.(ABSTRACT TRUNCATED AT 250 WORDS)

Child↗
PubMedDate not supplied

Circadian rhythms in polyamine excretion by rats bearing an immunocytoma.

Large-amplitude circadian rhythms were observed in the urinary excretion of polyamines by rats bearing an immunocytoma. Control animals excreted polyamines at a lower rate but also with marked circadian variation. In confirmation of earlier observations, light-chain excretion by the tumor-bearing rats also exhibited a circadian rhythm, superimposed on an increasing trend. The potential of these rhythms as markers for the chronotherapy of cancer is noted.

Animals↗
PubMedDate not supplied

Repeated alcohol intake changes circadian rhythm of ambulatory blood pressure.

The blood pressure of 7 clinically healthy volunteering social drinkers was studied while they consumed, with a crossover design for 5 days, either 40 g of alcohol by day or fruit juice, with the two spans on alcohol and juice being separated by a one-week washout. Whereas the rhythm-adjusted mean was not changed, a clear statistically significant increase in the circadian double amplitude was found. The study provides a model for a rapidly achieved circadian amplitude hypertension which may precede an elevation of the overall blood pressure mean in the natural course of the disease.

Adult↗
PubMedDate not supplied

[The role of biological clocks in formation of standards, pathology, and in therapy. 1. Chronobiological aspects of formation of blood pressure in children with positive and negative family history of relatively high blood pressure].

There are a difference in average values and in amplitudes of about-7 and monthly rhythms of infants' blood pressure with positive and negative family history to the hypertension. Chronobiological approach to these problem can reveal hypertension risk at the early stage of life.

Biological Clocks↗
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The week in phylogeny and ontogeny: opportunities for oncology.

Like circadian systems, multiseptans are apparently frequent if not ubiquitous chronome components. There is growing evidence from both basic and applied viewpoints that built-in circaseptans play a role complementary to the circadian system as does the circasemiseptan component. We have here compared circaseptans and circasemiseptans, by reference to their corresponding circadians, in humans (at early stages of development or as adults in society vs. isolation in caves) and across species (notably in organisms identified as early inhabitants of the earth), in growth and regeneration, and in tumor markers, presumably reflecting the host carrying a malignant growth, in pre-disease and in overt illness. Intermodulations within the components of chronomes of a given set of variables, and among components of chronomes of different variables, the feedsidewards, are the basic characteristics of life. Many frequencies lower than those here considered, including the biologic year and a component corresponding to the length of the solar cycle have been opportunistically studied. Because of practicality only, the relation of circasemiseptan and circaseptan chronome components to circadian components was here explored as a hint that much information lies in the relations among rhythms with different frequencies, for oncologists in particular.

Adult↗