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Biomedical subjects

F Halberg

Publications and source records attributed to F Halberg.

At least 469 records · Page 26Linked to original sources
PubMedDate not supplied

Chronochemotherapy: L 1210 leukemia and beyond.

In cancer and other therapeutic research, an interpretation of median survival times can and should take cure into account. With this qualification, an analysis of recently published data provides further statistically significant evidence in favor of cancer chronotherapy as compared to homeostatic therapy.

Animals↗
PubMedDate not supplied

Toward a chronopsy: part II. A thermopsy revealing asymmetrical circadian variation in surface temperature of human female breasts and related studies.

A thermorhythmometric analysis was carried out on data from a patient who underwent a prophylactic subcutaneous mastectomy, subsequently to a preoperative mammogram revealing clustered small calcifications in the left breast. The patient self-measured surface temperature of each breast, above and below the nipple, at intervals of 75 +/- 10 min for 59 h while awake. In one location of each breast, the recording thermistor-probe was insulated for 21.5 h while other probe locations remained uninsulated. The overall rhythm-adjusted average surface temperature and the extent of predictable circadian variation differed with statistical significance when the two breasts were compared. The left breast exhibited a higher rhythm-adjusted mean temperature and a lower extent of predictable circadian variation, as compared to the contralateral breast. The interbreast differences of surface temperature also demonstrated a statistically significant rhythm. A review on results of rhythmometry of breast temperature was also carried out. The thermorhythmometric findings here reported must not necessarily be regarded as indicative of cancer; they may be found in non-cancerous subjects and may or may not reflect early pathology. The objective of this publication is to suggest that non-invasive mammary thermorhythmometry may complement clinical histopathology. This subject may exemplify a new principle awaiting scrutiny with much more extensive sampling and much longer follow-up, namely that chronopathology including chronoprotopathology, alongside established diagnostic procedures, may provide an indication for prophylactic intervention.

Adult↗
PubMedDate not supplied

Strain-difference in circadian murine chronotolerance to the antidepressant drug nomifensine.

The anti-depressant drug nomifensine (8-amino-1,2,3,4-tetrahydro-methyl-4-phenylisoquinoline) was administered at several dose levels to mice of 2 inbred strains at one of 6 circadian times 4h apart under conditions standardized for light-dark synchronized rhythmometry. A circadian rhythm in tolerance to nomifensine reflected by differences in mortality was demonstrated for both C57 and DBA mice. An interstrain difference in tolerance was also observed.

Animals↗
PubMedDate not supplied

Nomifensine chronopharmacology, schedule-shifts and circadian temperature rhythms in di-suprachiasmatically lesioned rats--modeling emotional chronopathology and chronotherapy.

Some emotional disorders are associated with alterations of biological rhythm characteristics ('echronism'). Chronotherapy aims empirically to 1. optimize the kind and timing of conventional psychopharmacologic treatment and, need be, to use such old or new molecules in the rational endeavor to 2. correct (disease-determining) rhythm alteration directly. With respect to the first aim, a reduction by timing of undesired pharmacodynamic effects, as well as an amplification of empirically desired ones, can be dramatically illustrated by circadian rhythms in tolerance to many drugs affecting the central nervous system of rodents. A more rational approach is aimed at correcting ecchronism. The new antidepressant drug, nomifensine, achieves this task in rats with bilateral suprachiasmatic lesions, exhibiting in the telemetered core temperature an echronism of varying degrees. In this model system for the chronobiotic treatment of ecchronism, the properly timed administration of nomifensine speeds the adjustment of bilaterally (suprachiasmatically) lesioned rats to a shift in the synchronizing light-dark schedule. With methodologic provisions, notably for treatment timed by pertinent marker rhythms, nomifensine deserves clinical tests in psychochronotherapy.

Animals↗
PubMedDate not supplied

Psychophysiologic circadian rhythmometry on manic-depressive twins.

Rhythmometry on emotionally disturbed identical twins is applied for study of possible emotional chronopathology. Several circadian rhythmic variables are apparently 24-h synchronized in both twins, during a study span associated with mania in one twin and apparently 'normal' behavior in the other. While the data span of 3 weeks does not allow validation of any desynchronization with a period quite near to 24 h in the case of a manic girl, it does not rule out the possibility of uncoupling of an adrenal cortical cycle, gauged by the circadian rhythm in urinary 17-ketosteroid excretion. The question whether circadian or other dyschronism was present, and, if so, represented a trivial corollary or, perhaps, a determinant of emotional pathology, remains unanswered. The methodology here illustrated and added tests of differences in rhythm characteristics are likely to provide answers to such questions when they are combined with therapeutic manipulations and the search for possible chronobiotic drugs.

17-Ketosteroids↗
PubMedDate not supplied

Circannual variation in human erythrocyte adenosine aminohydrolase.

In serially independent samples of blood from apparently healthy subjects controlled as to clock-hour of blood withdrawal but not as to any circannual changes in circadian state, human erythrocyte adenosine aminohydrolase undergoes a statistically significant circannual rhythm, which may or may not be aliased. This rhythm is also demonstrated in patients with a variety of neoplastic diseases and it occurs around a statistically significantly lower mesor in patients with a variety of malignant tumors investigated.

Adenosine Deaminase↗