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Biomedical subjects

F Hagemeijer

Publications and source records attributed to F Hagemeijer.

At least 37 records · Page 2Linked to original sources
PubMed1982

Benefits from adding nifedipine to the treatment of unstable angina when beta-blockade and isosorbide dinitrate have proved inadequate.

Nifedipine (10 mg orally six times daily) was given to patients with unstable angina persisting despite adequate beta-blockade (group I, 35 patients) or despite the association of adequate beta-blockade and sublingual isosorbide dinitrate (group II, 47 patients). Stabilization of anginal symptoms was achieved in 31/35 patients of group I and in 39/47 patients of group II. Aorto-coronary bypass grafting was carried out in 19 patients because of persisting unstable angina (five patients) or because of the severity of residual angina (14 patients). Tolerance to these drug combinations was excellent, with side-effects consisting mainly of transient headache (eight patients) and noncardiac ankle edema (eight patients). Nifedipine was found to be valuable in stabilizing unstable angina persisting despite beta-blockade and nitrates.

Aged↗
PubMed1980

Aprindine: a review.

Explore the source record for details and available documents.

Administration, Oral↗
PubMed1980

Echocardiography and rupture of the heart.

In four patients with rupture of the free wall of the left ventricle, the diagnosis was made at the bedside using a portable cross-sectional echocardiograph; this was confirmed at necropsy in two patients and by paracentesis in the other two. Weak ventricular contractions were seen after each QRS complex of the electrocardiogram, contradicting a widespread belief that cardiac rupture immediately produces electromechanical dissociation. In one patient aspiration of 100 ml blood from the pericardium allowed resumption of cardiac pump function; this patient survived for three days but was allowed to die because of cerebral damage sustained during resuscitation.

Aged↗
PubMed1979

Echocardiological contrast studies with dynamically focussed multiscan.

Bidimensional contrast echocardiological examinations were carried out in 120 patients with the use of dynamically focussed multiscan. Ultrasonic contrast was produced by a push injection of 10 ml of isotonic saline or of 5% glucose in water injected into an antecubital vein through an 18 gauge needle. Contrast studies were observed on a television monitor and recorded on videotape for detailed off-line analysis. All the echocardiological diagnoses presented here were confirmed during catheterization. A few typical clinical examples are illustrated, including a patient with Ebstein's anomaly, a case of tricuspid regurgitation, atrial and ventricular septal defects, and a left ventricular ultrasound angiocardiogram. Bidimesional contrast opens a new field for the assessment of remediable cardiac lesions.

Angiocardiography↗
PubMed1979

Intra-aortic balloon pumping in coronary artery disease.

Cardiogenic shock and severe left ventricular failure after acute myocardial infarction, refractory angina pectoris at rest either of new onset or superimposed on stable angina pectoris, or occurring in the post infarct (less than 2 weeks) period, and the suspicion of a slowly evolving infarction are the main indications for intra-aortic balloon pumping at the Thoraxcenter. 76 patients were treated with intra-aortic balloon pumping for cardiogenic shock after acute myocardial infarction and left ventricular failure, 42/76 (55%) could be weaned, 9 (12%) died within 3 months, 33 (43%) survived over 3 months, to date 29 are alive. 42 patients with refractory angina at rest were treated with intra-aortic balloon pumping. Pain relief was prompt in 41 (98%), who subsequently underwent coronary artery bypass grafting. Total myocardial infarction rate was 11% (5/42), total mortality rate was 7%. Perioperative myocardial infarction rate was 8% (4/42) and perioperative mortality was 7% (3/42). Pain relief was prompt in 14/17 patients (82%) with post infarct refractory angina. In 3 patients pain persisted despite intra-aortic balloon pumping, all sustained a myocardial infarction, 1 died, 2 other patients were excluded for surgery. 12 patients underwent coronary artery bypass grafting, none died, none developed acute myocardial infarction, 3 have mild stable angina. In 8 patients a slowly evolving myocardial infarction was suspected. Pain relief was prompt in 7/8 (88%) after institution of intra-aortic balloon pumping. Intra-aortic balloon pumping improves prognosis in cardiogenic shock after myocardial infarction, and abolishes refractory ischemic pain.

Adult↗
PubMed1978

Verapamil in the management of supraventricular tachyarrhythmias occurring after a recent myocardial infarction.

In 16 patients, a sustained supraventricular tachyarrhythmia occurring less than 72 hours after the first symptom of an acute myocardial infarction was treated with titrated doses of verapamil. The drug was given intravenously in 1 mg increments every minute under continuous monitoring of electrocardiogram and blood pressure. Endpoints for the administration of verapamil were the following: reversion to sinus rhythm; a ventricular rate slower than 100/min; hypotension; a pulmonary capillary wedge pressure rising above 15 mm Hg; signs of intolerance; a maximum dose of 20 mg. Reversion to sinus rhythm was observed in 7/8 patients in atrial flutter and in 1/8 patients in atrial fibrillation; in all the ventricular rate could be slowed below 100/min without untoward effects.

Blood Pressure↗
PubMed1978

Progressive development of a left ventricular thrombus.

In a patient with ischemic heart disease and terminal left ventricular failure, echocardiographic techniques (single-crystal M-mode echocardiograms and bidimensional, linear, dynamically focussed multiscan recordings) allowed the detection and follow-up of a left ventricular thrombus, later documented at autopsy.

Coronary Disease↗
PubMed1978

[Contrast echocardiology in two dimensions and in real time. 1. Ultrasonic techniques].

An aqueous solution (5% glucose) injected rapidly into a peripheral vein modifies the acoustic homogeneity of the blood not only at the periphery, but also within the cavities of the heart. This ultrasonic contrast technique has taken a new lease of life thanks of two-dimensional echocardiology in real time, which allows the blood to be visualised as it moves. A description is given of the current two-dimensional real time transducers, and the dynamically focal multiscan which has been developed in our laboratories. An analysis is made of the chosen ultrasonic contrast medium (glucose water), of the site and mode of injection, of the recording technique and of the various echocardiological views. Finally, a discussion highlights the limitations of single crystal echocardiography, and the advantages of the two-dimensional technique in real time.

Contrast Media↗
PubMed1978

[Contrast echocardiography in two dimensions and in real time. 2. Clinical applications].

The anatomical and functional abnormalities which are the basis of septal defects and valvular incompetence can be visualised directly by two-dimensional contrast echocardiology. Although right-left shunts at atrial or ventricular level can easily be discovered and visualised after injection peripherally, the same is not true of left-right ventricular shunts; these are not detectable. As for left-right shunts (as demonstrated by oxymetry) at the atrial level, these are in a separate category; the passage of ultrasonic contrast medium from right to left is inconstant. This technique also allows the study of abnormal blood flow: tricuspid incompetence, turbulence caused by prosthetic valves, etc.

Adolescent↗