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Biomedical subjects

F Högl

Publications and source records attributed to F Högl.

13 recordsLinked to original sources
PubMed1981

[The activity of imidazole derivatives in the presence of human plasma (author's transl)].

By Warburg technique using yeasts and staphylococci, any decrease in antimicrobial activity of the imidazole derivatives could be excluded in the presence of human plasma. Econazole nitrate, the classical topical imidazole derivative, and ketoconazole, an oral active antifungal, were tested. The compatibility between imidazole derivatives and human plasma is of practical importance for obtaining optimal therapeutic results in treating human mycoses.

Antifungal Agents↗
PubMed1980

[Effect of imidazole derivatives on various numbers of microbes to determine microbial sensitivity].

Imidazole derivatives with antifungal activity were investigated in their effects on concentrated and diluted suspensions of Saccharomyces cerevisiae, Candida albicans, and Staphylococcus aureus haemolyticus. Against Candida albicans, activity of the imidazol derivatives was higher in diluted suspensions than in concentrated suspensions: this fact proves the presence of a microbe-count sensitivity. Against Saccharomyces cerevisiae and Staphylococcus aureus haemolyticus, no microbe-count sensitivity of clotrimazole, econazole nitrate, ketoconazole, or N-148/76 could be detected by Warburg assay on resting microbes.

Candida albicans↗
PubMed1980

[Interactions between amphotericin B and hydroxytetracycline].

By means of the Warburg assay (manometric technique), investigations were performed to elucidate interactions between amphotericin B, a polyene antifungal antibiotic, and hydroxytetracycline. Those two compounds were combined in clinical therapy. On resting yeasts and bacteria, interactions could be ruled out. On the contrary, on both types of microbes a significant increase in antimicrobial actions could be seen in the presence of the second substance. The antimycetic activity of amphotericin B was significantly increased in the presence of hydroxytetracycline (in five-fold concentrations). The antibacterial activity of hydroxytetracycline was significantly higher in the presence of amphotericin B (same concentrations). The clinical implication of these results is briefly discussed.

Amphotericin B↗