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Biomedical subjects

F H Straus

Publications and source records attributed to F H Straus.

At least 55 records · Page 3Linked to original sources
PubMed1978

Patterns of human thyroid parenchymal reaction following low-dose childhood irradiation.

Microscopic changes in the thyroids of 68 patients who had received low-dose childhood irradiation to the head and neck and who presented with palpable thyroid abnormalities culminating in surgery are compared to 34 control thyroids obtained from age- and sex-matched autopsy cases. Eighty-eight percent of irradiated thyroids showed moderate to severe focal hyperplasia, 51% contained single or multiple adenomas or adenomatous hyperplastic nodules, 68% exhibited chronic lymphocytic thyroiditis, 51% revealed colloid nodules, 42% presented with oxyphile change, 25% had mild fibrosis and 59% contained well-differentiated papillary, follicular or mixed thyroid carcinoma averaging 1.6 cm in diameter. Three small carcinomas were of the sclerosing type. The non irradiated thyroids showed 32% colloid nodule formation, 17% focal hyperplasia, 6% adenomatous hyperplasia and no identifiable carcinomas. Several nonspecific histologic abnormalities are now recognized as following low-dose radiation to the thyroid, the most important being focal hyperplasia, which may represent a pre-malignant change in thyroid parenchyma.

Adolescent↗
PubMed1978

Pathological aspects of the infertile testis.

In this review, the pathological findings from testicular biopsies of men suffering from various types of infertility are presented. The causes of male infertility are divided into three major categories: pretesticular, testicular, and post-testicular causes. The pre-testicular causes of infertility may be defined as extra-gonadal endocrine disorders, such as those originating in the hypothalamus, pituitary, or adrenals, which have an adverse effect on spermatogenesis. The testicular causes of infertility are primary defects of the testes. The post-testicular causes of infertility consist primarily of obstructions of the ducts leading away from the testes. Cases in which the spermatozoa are normal in number but greatly impaired in motility, presumably due to faulty maturation or improper preservation of the spermatozoa during their sojourn in the epididymides, or due to biochemical abnormalities of the seminal plasma, are also included in the postesticular category.

Androgens↗
PubMed1977

Roentgenographic findings in work hypertrophy of the muscularis propria of the terminal ileum.

This case is presented as an uncommon example of valvulae thickening caused in part by work hypertrophy of the circular muscular layer. This normal response of smooth muscle may occur in association with progressively obstructing lesions of the colon or ileocecal valve. Recognition of a similar abnormal small-bowel appearance may suggest the presence of a more distal obstructing lesion.

Adenocarcinoma↗
PubMed1977

Squamous carcinoma of the stomach after luetic linitis plastica.

This report illustrates many of the long term complicatio of syphilis involving the stomach. A 49-year-old woman with diffuse squamous metaplasia of the gastric mucosa developed invasive pure squamous cell carcinoma. The literature is reviewed and the probable pathophysiology is discussed.

Adenocarcinoma, Scirrhous↗
PubMed1975

Osteosclerosis in primary hyperparathyroidism.

Osteosclerosis in adults with primary hyperparathyoidism is rare; the usual skeletal manifestation, when presented, is diffuse osteropenia. We describe a patient with generalized osteosclerosis in association with primary hyperparathyroidism. The findings are documented by conventional and fine-detail radiography, absorptiometric bone mineral analysis, quantitative microradiography and histologic examination of bone. The unique features are contrasted with the manifestations recorded in a recently studied group of 87 hyperparathyroid patients. The data presented here support a causal relationship in this patient between parathyroid hormone excess and the development of densely sclerotic bones.

Adenoma↗
PubMed1975

Thyroid hemangioma.

A case is presented of a fifty-six year old man with a thyroid hemangioma presenting as a neck mass with tracheal deviation and unilateral vocal cord paralysis. A standard thyroid scan yielded equivocal findings. The diagnosis was determined preoperatively by the use of a 99m-technetium angiogram that disclosed the vascular nature of the lesion. Subsequent arteriography demonstrated the main arterial supply of the mass to be from both inferior thyroid arteries. Operative removal of the mass was accomplished through a standard transverse cervical incision. Pathologic study revealed that the vascular tumor involved both the surrounding normal thyroid parenchyma and also a microfollicular adenoma. This case points out the value of utilizing all available diagnostic means in atypical cases of thyroid disease.

Angiography↗
PubMed1975

Papillary clear cell carcinoma of the thyroid gland.

A case of an unusual papillary clear cell carcinoma of the thyroid gland is described. The patient expired 17 days after operative biopsy and thyroxine suppression. Special stains were helpful in differentiating renal cortical carcinoma and parathyroid malignant disease from primary papillary clear cell carcinoma of the thyroid. Ultrastructural features of this tumor may relate to the effects of thyroid stimulating hormone as well as the malignant nature of the tumor.

Adenocarcinoma↗