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Biomedical subjects

F H Rampen

Publications and source records attributed to F H Rampen.

At least 37 records · Page 2Linked to original sources
PubMed1992

Trends in mortality from malignant cutaneous melanoma in The Netherlands, 1950-1988.

This paper presents an analysis of trends in mortality from malignant melanoma of the skin in The Netherlands, 1950-1988. Statistical analyses show that time period effects are needed to describe the mortality trends in The Netherlands. Because this contrasts with reports from other countries, in which the trends were ascribed to a cohort effect only, log-linear models including the three factors age, time period and birth cohort, were fitted to the data. To be able to separate time period effects from birth cohort effects we assumed a mathematical function for the mortality rates in relation to age. The results obtained in this way indicate that time period effects increased up to 1970. An increase of birth cohort effects is seen for cohorts born between 1900 and 1955. For cohorts born after 1955 the mortality from melanoma seems to decrease. The most plausible explanation for the time period effect probably is improvement in death certification.

Adolescent↗
PubMed1992

Fundamentals of skin cancer/melanoma screening campaigns.

There is increased world-wide concern about the rising incidence of melanoma and non-melanoma skin cancer. Screening theoretically reduces death and morbidity from skin cancer/melanoma. Visual examination of the skin is a rapid, safe and inexpensive screening tool. In this review the fundamentals of early disease detection before implementation of a public-health screening programme are critically analysed with reference to the skin cancer/melanoma, epidemic. It is concluded that skin cancer/melanoma fulfils, for the most part, the criteria enunciated by Wilson and Jungner in 1968. However, information about the effect of screening on reducing incidence and mortality is still lacking. Future research should focus on methods of improving compliance and on the costs and benefits of such screening programmes.

Mass Screening↗
PubMed1992

Practical considerations of melanoma/skin cancer screening clinics.

In 1989 a voluntary melanoma/skin cancer screening clinic was held in Oss, the Netherlands. The campaign was carried out according to the free clinics conducted since 1985 in the USA. Our experiences with the first clinic urged us to improve on the organization of the screen. This produced a better yield of the second screen, conducted in 1990 in Arnhem. In this paper we present the practical and organizational implications of melanoma/skin cancer screening based on both screening exercises. It is emphasized that only dermatologists should screen. Concomitant public education will enhance self-selection of people at risk for melanoma/skin cancer. There should be ample provider time, sufficient auxiliary personnel and abundant examination rooms. Total-body skin examination is optional. Follow-up of positive screenees is mandatory. It is concluded that melanoma/skin cancer screening is feasible, particularly in countries with a high dermatologist-to-patient ratio.

Advertising↗
PubMed1991

Melanoma/skin cancer screening clinics: experiences in The Netherlands.

In 1989 and 1990 we conducted two free melanoma/skin screening clinics in Oss and Arnhem in the Netherlands. The study was carried out along the lines of the recent campaigns supported by the American Academy of Dermatology. Of 2564 persons screened, 53 had melanoma or nonmelanoma skin cancer (2.1%). Compliance with follow-up for persons with suspected melanoma/skin cancer was adequate (93 of 103; 90.3%).

Basal Cell Carcinoma↗
PubMed1990

[Revised consensus melanoma of the skin].

A second consensus meeting on cutaneous melanoma was held on June 15, 1990. The present report concisely discusses the recommended policy concerning the diagnosis and treatment of melanoma. The changes in melanoma management in comparison with the first consensus meeting in 1984 are emphasized.

Combined Modality Therapy↗
PubMed1990

[Epidemiology of melanoma of the skin in The Netherlands: a descriptive study].

A study of the mortality rates of cutaneous malignant melanoma over the period 1950-1985 in The Netherlands showed a fourfold increase of mortality. An analysis by birth cohort suggests a cohort effect: age-specific mortality rates increase with successively younger generations. To determine the incidence of malignant melanoma of the skin data were derived from a registration of histological diagnoses of diseases (PALGA). The estimated numbers of new cases of melanoma of the skin were 1270 and 1372 in the years 1986 and 1987 respectively. Data on the trend in incidence are restricted, but indicate an increase. This descriptive study allows no conclusions about the cause of the rise in incidence and mortality rates.

Adolescent↗
PubMed1990

Prevalence of naevocytic naevi after chemotherapy for childhood cancer.

The frequency of naevocytic naevi (moles) in patients with childhood haematologic malignancies was studied. All patients had received multiple chemotherapy. The majority had also received cranial irradiation as part of their central nervous system leukaemia/lymphoma prophylaxis. Total body mole counts of the patients were compared with those of their healthy brothers and sisters. The median number of moles in the patient group was 20.0 (n = 79), in the healthy sibs 11.0 (n = 88). In two subgroups mole counts of male and female patients were compared with those of their closet brother or sister. There were 19 male and 19 female pairs for comparison. Median numbers of moles were significantly higher in both patient groups than in the controls (P less than 0.05). It is suggested that multiple chemotherapy (and/or cranial irradiation) may induce or activate naevocytic naevi. These findings may have important implications with regard to the aetiology of melanoma.

Adolescent↗
PubMed1990

Methotrexate and trimethoprim-sulphamethoxazole--a potentially hazardous combination.

A 74-year-old woman had been treated with methotrexate over 2 years for rheumatoid arthritis. She was admitted to the hospital because of non-healing leg ulcers. After being treated with trimethoprim-sulphamethoxazole for a urinary-tract infection, she developed severe pancytopenia, followed by pneumonia and septic shock. The patient died shortly after. Concomitant treatment with methotrexate and sulphonamides should be strongly discouraged.

Aged↗
PubMed1990

Sweet's syndrome.

Explore the source record for details and available documents.

Acute Disease↗
PubMed1989

[Evaluation consensus melanoma of the skin based on pathologic-anatomic reports].

On September 15, 1984 a consensus development conference on cutaneous melanoma was held. The consensus statement included explicit guidelines on the management of patients with primary and metastatic melanoma. For evaluation of the post-conference compliance among clinicians, 383 histopathological reports prepared by 19 pathology laboratories in 1986 and 384 reports dating from 1988 were analysed and the data compared with those in 324 reports dating from 1983, one year before the consensus conference. The present study is confined to the details of the histopathological description and the type of diagnostic procedure conducted by the physician. There was a substantial increase in the percentages of cases in which Breslow thickness was reported (1983: 83%, 1986: 91%, 1988: 97%). Also, other microscopical parameters were more detailed after the consensus conference.

Humans↗