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Biomedical subjects

F H Norris

Publications and source records attributed to F H Norris.

At least 37 records · Page 2Linked to original sources

Culture and domestic violence: the ecology of abused Latinas.

This study examined the predictors of domestic violence within a sample of 60 immigrant Latinas, of whom 30 had sought assistance for abuse and 30 had sought other family services. Hypotheses were derived from several frameworks relevant to understanding abuse--intrapsychic (learned helplessness), interpersonal (family violence), and feminist theory. Findings related to the specific formulations were subsequently combined into a model of abuse in which the mutuality of communication within the couple mediates the effects of husband's intoxication and environmental stressors on the occurrence/severity of abuse. The study points out the inadequacy of relying on any one existing theory and supports the idea of taking an ecological approach to the study of abuse in specific populations.

Acculturation↗

Spinal fluid cells and protein in amyotrophic lateral sclerosis.

The cerebrospinal fluid total protein in 385 cases of sporadic amyotrophic lateral sclerosis showed no relationship to survival, but it was related to survival time in 34 cases of familial amyotrophic lateral sclerosis. Infrequent and mild pleocytosis, and oligoclonal bands seemed to have no clinical significance in well established cases of amyotrophic lateral sclerosis.

Aged↗

Amyotrophic lateral sclerosis: lower motor neuron disease spreading to upper motor neurons.

Contrary to the recently reemphasized notion that the primary neuron involved in amyotrophic lateral sclerosis (ALS) is the cortical (upper) motor neuron (UMN), we believe that the lower motor neuron (LMN) is primarily involved by the retrograde transport of pathogens from neuromuscular junctions, and the disease process spreads monosynaptically to the UMN. Pathologically and epidemiologically, the LMN hypothesis is more logical than the UMN in light of the recent understanding of neuroaxonal transport systems, particularly in regard to anterograde cytoskeleton transport and the kinetics of the force promoting slow axonal transport. By correlating the early pathologic findings, i.e., the swelling of the initial axons and formation of intracytoplasmic inclusions in the LMN, ALS may be regarded as a disease of axonal transport, especially its slow component (SCa). Therapeutic intervention to facilitate SCa should be attempted in ALS.

Amyotrophic Lateral Sclerosis↗

A test of the social support deterioration model in the context of natural disaster.

This prospective longitudinal study examined stress-mediating potentials of 3 types of social support: social embeddedness, perceived support from nonkin, and perceived support from kin. As participants in a statewide panel study, 222 older adults were interviewed once before and twice after a severe flood. It was hypothesized that disaster exposure (stress) would influence depression directly and indirectly, through deterioration of social support. LISREL analyses indicated that postdisaster declines in social embeddedness and nonkin support mediated the immediate and delayed impact of disaster stress. No evidence was found for the mediational role of kin support. Findings are in accord with conceptualizations of social support as an entity reflecting dynamic transactions among individuals, their social networks, and environmental pressures.

Adaptation, Psychological↗

Age differences in the psychological consequences of Hurricane Hugo.

At 12, 18, and 24 months after Hurricane Hugo, 831 adults were interviewed regarding their disaster-related stressors and present psychological state. The study's purposes were to assess whether age influenced one's vulnerability to postdisaster stress and to evaluate four different perspectives on disaster recovery that have been previously used to explain age differences. Regression analyses demonstrated that disaster exposure had substantial and pervasive psychological effects. The analyses also revealed a curvilinear interaction between disaster exposure and age. Younger people exhibited the most distress in the absence of disaster, but middle-aged people did so in its presence. Differential exposure, resources, and inoculation all failed to explain these differences, however, the burden perspective had considerable explanatory power.

Adolescent↗

Trial of oral physostigmine in amyotrophic lateral sclerosis.

We evaluated a double-blind, placebo-controlled, and double-crossover trial of oral physostigmine salicylate for a 9-month period in 13 of 25 patients with sporadic amyotrophic lateral sclerosis (ALS). A large dropout rate of 48% was secondary to eight deaths and four exclusions attributed to the incapability to swallow the tablets (physostigmine) and capsules (lecithin) or to attend the clinic. Parameters used for assessment of the drug efficacy included body weight, ALS score, Jamar grip strength, forced vital capacity, and maximum voluntary ventilation. It revealed slight benefit in reduced loss of grip strength compared with the pretrial and placebo periods. However, the rates of decline for body weight, ALS score, forced vital capacity, maximum voluntary ventilation, and megascore did not differ significantly between the pretrial, placebo, and physostigmine periods. We therefore concluded that overall no significant alteration in the clinical course was gained by oral physostigmine therapy in the 13 patients with ALS who were included in this study.

Administration, Oral↗

ALS and eye movements.

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Amyotrophic Lateral Sclerosis↗

Social support and victims of crime: matching event, support, and outcome.

Investigated the buffering properties of six types of social support (three perceived, three received) with regard to four psychological consequences (depression, anxiety, fear of crime, hostility) of criminal victimization (violent crime, property crime). These relationships were examined using longitudinal data collected from a sample composed of representative subsamples of victims and nonvictims. Effects of the perceived support measures (perceived appraisal support, perceived tangible support, self-esteem) were more pervasive than those of the received support measures (received informational support, received tangible support, received emotional support). Perceived support consistently exhibited buffering effects, protecting both violent and property crime victims against various symptoms they would have otherwise experienced. The stress-buffering capabilities of received support were limited to informational and tangible help protecting victims of violence from experiencing excessive fear. These findings are discussed in the context of recent theoretical developments concerning the stress-support matching hypothesis.

Adaptation, Psychological↗

A longitudinal study of the effects of various crime prevention strategies on criminal victimization, fear of crime, and psychological distress.

Examined the effects of precautionary behavior on subsequent criminal victimization, fear of crime, and psychological distress. A sample of 538 adults was interviewed three times at 6-month intervals. Four different aspects of precaution were assessed: vigilance (alertness), locks (access control), neighbors (informal cooperation), and professionals (formal programs). In logistic regressions that controlled for 14 risk factors, precaution had no preventive effects on the occurrence of subsequent crimes. LISREL models revealed that use of neighbors was the only precaution not to increase fear of crime, although both locks and neighbors showed a capacity to buffer the effects of fear on generalized distress. It was concluded that the most promising strategy was protective neighboring. Altogether, however, the promotion of citizen-initiated prevention appears highly inadequate as a policy response to problems of crime and fear.

Adult↗

Crime, social status, and alienation.

Explored the ecological consequences of crime and violence. Selected to reflect alienation between individuals and their settings, the criterion measures were fear of crime, avoidance behavior, anomia, and external locus of control. Exposure to crime was assessed at both individual and community levels. Using data from a large statewide sample of adult Kentuckians, hierarchical regression analyses were performed in which the criterion variables were regressed on measures of social status (e.g., education, sex), crime, and interactions between the two. The pattern of results highlighted the pervasive consequences of experiencing personal violence; effects of property crime and community-level exposure were more limited in scope. Social status also exerted strong effects on the criterion measures and modified many of the observed effects of crime. Implications of the study for interventions are discussed.

Adaptation, Psychological↗

Epidemiology of trauma: frequency and impact of different potentially traumatic events on different demographic groups.

The frequency and impact of 10 potentially traumatic events were examined in a sample of 1,000 adults. Drawn from four southeastern cities, the sample was half Black, half White, half male, half female, and evenly divided among younger, middle-aged, and older adults. Over their lifetimes, 69% of the sample experienced at least one of the events, as did 21% in the past year alone. The 10 events varied in importance, with tragic death occurring most often, sexual assault yielding the highest rate of posttraumatic stress disorder (PTSD), and motor vehicle crash presenting the most adverse combination of frequency and impact. Numerous differences were observed in the epidemiology of these events across demographic groups. Lifetime exposure was higher among Whites and men than among Blacks and women; past-year exposure was highest among younger adults. When impact was analyzed as a continuous variable (perceived stress), Black men appeared to be most vulnerable to the effects of events, but young people showed the highest rates of PTSD.

Adult↗

Functional versus structural social support, desirable events, and positive affect in older adults.

The independent contributions of structural social support versus functional support to positive affect in older adults were compared in this prospective design. Four social support models were translated from the stress-symptoms literature into promotional models for positive mental health and for relationships to desirable challenge events. A total of 1,031 older adults were interviewed 5 times at 6-month intervals, and events were measured across the middle 18-month period. The 2 support variables made quite different contributions. Functional support was directly related to positive affect 2 years later, independent of events; structural support had more transitory direct effects. Structural support, but not functional support, was related to the subsequent occurrence of challenge events and in turn was strengthened by challenge events, suggesting a dynamic interplay between the social network and desirable events.

Adaptation, Psychological↗

Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis.

Neuritic plaque and cerebrovascular amyloid deposits have been detected in the aged monkey, dog, and polar bear and have rarely been found in aged rodents (Biochem. Biophy. Res. Commun., 12 (1984) 885-890; Proc. Natl. Acad. Sci. U.S.A., 82 (1985) 4245-4249). To determine if the primary structure of the 42-43 residue amyloid peptide is conserved in species that accumulate plaques, the region of the amyloid precursor protein (APP) cDNA that encodes the peptide region was amplified by the polymerase chain reaction and sequenced. The deduced amino acid sequence was compared to those species where amyloid accumulation has not been detected. The DNA sequences of dog, polar bear, rabbit, cow, sheep, pig and guinea pig were compared and a phylogenetic tree was generated. We conclude that the amino acid sequence of dog and polar bear and other mammals which may form amyloid plaques is conserved and the species where amyloid has not been detected (mouse, rat) may be evolutionarily a distinct group. In addition, the predicted secondary structure of mouse and rat amyloid that differs from that of amyloid bearing species is its lack of propensity to form a beta sheeted structure. Thus, a cross-species examination of the amyloid peptide may suggest what is essential for amyloid deposition.

Alzheimer Disease↗

Differential social support and life change as contributors to the social class-distress relationship in older adults.

Four hypotheses previously put forth to explain the strong association between social class and mental health in the general population were examined in 1,326 older adults (55 years and older). Respondents were interviewed 3 times at 6-month intervals. Lower class was associated with more past life changes (occurring before Wave 1) and more subsequent life events (occurring between Waves 1 and 3); these changes were predictive of distress, supporting the differential exposure hypothesis. Lower class was associated with weaker social support (embeddedness), which was related to distress, supporting the resource deterrent hypothesis. There was little evidence that people of the lower classes were more vulnerable to stress or that their status was due to their weaker social support; thus, the differential vulnerability and applied buffering hypotheses were not consistently supported. Social support does appear to be a versatile resource for older adults. A significant portion of the class-distress relationship was not accounted for by life change, social support, or the interaction between these factors.

Adaptation, Psychological↗

Use of mental health services among victims of crime: frequency, correlates, and subsequent recovery.

The use of mental health services was examined within a sample of 392 victims of crime who were generally representative of that population in Kentucky. Respondents were interviewed twice at a 6-month interval. Of these victims, 12% had contact with mental health professionals within the first few months postcrime. Hierarchical discriminant analyses revealed that use of mental health services was most prevalent when depressive symptoms were present and the crime involved violence. Among victims of violence, urban residence, high social support, internal locus of control, and prior crime experience were also associated with use. The victims who recovered from the event most rapidly were those who reported receiving mental health services at both Waves 1 and 2. Implications of the study for policies and programs are discussed.

Adaptation, Psychological↗

Social support, life events, and stress as modifiers of adjustment to bereavement by older adults.

As part of a larger panel study, interviews were obtained from 3 samples of older adults: 45 persons who had recently lost a spouse, 40 who had lost a parent or child, and 45 who were not bereaved. Assessments were conducted before and after the deaths. In the widowed sample, health remained quite stable, but depression increased sharply, then remained elevated. Changes were minimal in the sample who had lost a parent or child and in the nonbereaved sample. Multiple regression procedures were used to identify factors that contribute to depression and health 9 months after the spouse's death. Postbereavement depression was associated with higher prebereavement depression, higher financial pressures, higher global stress, fewer new interests, and lower social support. Health was a function of prebereavement health, new interests, financial pressures, and global stress. In general, life events and resources had stronger effects in the widowed sample than in the comparison samples.

Adaptation, Psychological↗

Polio and ALS.

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Aged↗