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Biomedical subjects

F H Jones

Publications and source records attributed to F H Jones.

10 recordsLinked to original sources

Cerebrospinal fluid immunoelectrophoresis in multiple sclerosis.

In 95 patients with definite multiple sclerosis (MS) cerebrospinal fluid (CSF) cytomorphology, protein electrophoresis and immunoelectrophoresis using antisera to human serum, Fab fragments of immunoglobulin G(IgG) and to kappa and lambda light chains and the CSF IgG concentration were examined. In the CSF diagnosis of MS, the set of the examinations used is considered to be superior to any individual laboratory technique currently applied in the diagnostic process of MS. In the set of the CSF examinations, CSF immunoelectrophoresis revealed abnormal findings in patients with MS in whom presence of bands (oligoclonal gammopathy) in the gamma-globulin field of the CSF electropherogram and/or increased concentration of CSF IgG were not demonstrated.

Adult

Planning for the next generation of risk studies.

Seventy longitudinal studies of social competence in children conducted over the past 3 decades are critically reviewed in an effort to pinpoint current and potential problems in conducting longitudinal research with samples of children at elevated risk for developing severe forms of psychopathology. The review outlines chronic problems in accurately specifying objectives, choosing adequate and appropriate samples, and selecting maximally useful predictor and outcome measures in this reseach area. A variety of institutional and organizational problems that make risk research difficult to undertake and to carry to completion are also described. A federation of risk projects, which could seek unified funding and coordinate institutional support, is suggested. In addition, new grant review procedures that embody coordination of management efforts between funding and research agencies are recommended as one possible alternative to present practices.

Adolescent