[Friedrich Theodor Frerichs in Berlin].
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Berlin↗
Biomedical subjects
F H Franken
Publications and source records attributed to F H Franken.
[The history of gallstone manifestations].
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Animals↗
[Physicians' journals].
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Periodicals as Topic↗
[Ranitidine and cimetidine in the prevention of stress: ulcer hemorrhage a prospective comparative multicenter study].
In a multicentre single-blind study, ranitidine was compared to cimetidine as prophylactic treatment against stress-induced upper gastrointestinal bleeding in seriously ill patients in the intensive care unit (ICU). 380 patients entered the study. 192 patients were treated with ranitidine 50 mg q.i.d. as i.v. bolus followed by 150 mg orally twice daily. 188 patients received cimetidine 400 mg q.i.d. intravenously and 1,000 mg daily orally in divided doses. Five patients in the ranitidine group (2.6%) and 12 in the cimetidine group (6.4%) developed gastrointestinal bleeding definitely or possibly due to stress lesions. This difference was not significant. The incidence of stress erosions or ulcerations developing during the study was 11.8% for the ranitidine group and 18.3% for the cimetidine group (non-significant difference). Adverse events in the ranitidine group were nausea, tachycardia or vomiting in 4 patients. 5 cimetidine-treated patients developed cholestasis, and 5 additional central nervous system problems. The high degree of efficacy of both drugs compared very favourably with the high incidence of stress ulceration and hemorrhage in similar untreated populations.
Adolescent↗
[Solitary liver abscesses in chronic brucellosis].
In two patients from southern Italy, the sonographic finding of great solitary focal liver lesions was contributed to brucella-abscesses (brucelloma) according to the clinical and serological data and to the results of ultrasonically guided fine needle aspiration biopsies. In both cases, laparotomy confirmed the diagnosis. We discuss the clinical findings and differential diagnosis of this uncommon inflammatory focal liver lesion.
Adult↗
[Sonographically assisted liver biopsy--replacement for blind needle biopsy?].
Since the beginning of 1980 the authors have performed upper-abdominal ultrasound examination immediately preceding percutaneous needle biopsy (after Menghini), previously performed "blind". Knowledge of the particular liver topography made it possible to perform reliably punctures with only a small number of multiple punctures (6.4%) being required, suitable biopsies more often being obtained than under laporoscopic control. Compared with 354 consecutive blind liver biopsies, guided biopsy caused pain from the puncture in 1.9% (previously 5.9%), with a reduction of need for analgesics from 4.5% to 1.1%. The rate of more serious complications was reduced from five (1.4%) to one (0.2%), although as a result of ultrasound the indications for percutaneous liver biopsy were more frequent, since numerous "classical" contra-indications could be ignored. Blind liver biopsy should thus be abandoned for ultrasound-guided percutaneous puncture.
Adolescent↗
[Coincidence of chronic pancreatitis and liver cirrhosis in alcohol abuse. A x-ray and histomorphological study].
We conducted a retrospective study in 112 chronic alcoholics in order to evaluate the incidence of simultaneous damage of both pancreas and liver. In all patients, an endoscopic retrograde pancreaticography (ERP) and a liver biopsy were performed. 65 patients had alterations of the pancreatic ducts compatible with the diagnosis of chronic pancreatitis. 30,7% (20/65) suffered from an additional alcoholic liver cirrhosis. This is a much more frequent association than presumed by H. Sarles et al. and Ammann et al. When the diagnosis was established, the average age of the group with chronic pancreatitis and liver cirrhosis was the same as in patients with chronic pancreatitis without cirrhosis (43,3 versus 42,4 years). Routine laboratory findings were of little value in comparison to the morphological findings.
Adult↗
[Nodular lymphoid hyperplasia of the small intestinal, hypogammaglobulinemia and rheumatoid arthritis (author's transl)].
A case report is given of a patient with intestinal nodular lymphoid hyperplasia, hypoimmunoglobulinemia and seronegative rheumatoid arthritis with extensive deformation of joints, who was diagnosed and followed for 10 years clinically and by repeated endoscopic and bioptic examinations. It could be shown for the first time by temporary omission of corticosteroids that continuous therapy with corticosteroids is indispensable in this disease.
Adrenal Cortex Hormones↗
[Expert judgement in liver disease (author's transl)].
Expert judgement on duration and extent of unfitness for work in various liver diseases is rather uniform nowadays. Problems are more often encountered when causal relationships have to be established or excluded, especially in medical personal suffering from liver disease. Since several years, however, the medical expert may relay upon more sophisticated diagnostic tools supplied by progress of virology of hepatitis. Further improvement of these tools within the next years is to be expected. This progress may as well facilitate judgement of causal relationships between effects of diseases occurred during the war and liver disease of recent origin. The medical expert in the field of hepatology has to be well acquainted with all recent knowledge and research results in virus hepatitis.
Expert Testimony↗
[Posthepatitic cirrhosis of the liver without symptoms: observance about 22 years (author's transl)].
There are only a few studies about sufficiently documented posthepatitic cirrhosis of the liver for more than two decennaries. Therefore we report about a patient, who showed at laparoscopy in 1954 a posthepatitic cirrhosis of the liver. Since the end of the fifty years the laboratory findings had normalized and the patient worked hard and felt himself well. At a control laparoscopy with liver biopsy in 1975 a complete inactive cirrhosis of the liver was confirmed. Blood samples were normal and HBsAG seronegative. Therefore, it seems to be possible, that in some few cases cirrhosis of the liver remaining without clinical symptoms over many years - for example in late prisoners of the war, who returned home with an inactive full developed cirrhosis of the liver - but now is detected.
Chronic Disease↗
[Etiology and management of habitual constipation (author's transl)].
Habitual constipation is present, if defecation occurs because of prolonged retention of stool in the colon less than three times per week. Motility of the intestine is increased in these cases, not decreased as has been thought for long time. Several factors of modern civilization favor habitual constipation, e.g. nutrition devoided of poorly digestible ingredients, and lack of physical exercise. The diagnosis of habitual constipation should only be made after careful exclusion of all organic causes by means of x-ray and endoscopic examination. Therapy is conservative in most cases. The diet ought to be rich in indigestible ingredients; eating and defecation habits have to be adapted to a regular pattern. Hydrophilic colloid laxatives may be used as well as in a limited extent laxatives effective on an osmotic basis. Laxatives acting more drastically or being effective upon contact with the intestinal mucosa are not suited for long-term therapy of constipation. Surgery is indicated only in a few cases.
Chronic Disease↗
[Bed rest, diet and working capability in liver disease (author's transl)].
General views concerning bed rest, diet and working capability in liver disease have changed during the last years. Rigorous bed rest in acute viral hepatitis is necessary only for short periods of time; it is necessary in chronic liver disease only in rare cases and during the terminal stage, respectively. A liver diet does not exist. Normal palatable nutrition is completely adequate in liver disease. Restriction of protein and sodium chloride intake is indicated only in cases with incumbent coma or with ascites. Patients suffering from acute viral hepatitis are incapable of working; however, they can go back to work a few weeks after the acute stage. Estimation of disability to work in patients with chronic liver disease may be difficult; no general rules can be given; in chronic active hepatitis disability is proportional to the activity of the disease and may range from 20-100%. Fatty liver without inflammatory changes does not influence working capability.
Acute Disease↗
[ERP and pancreatic sonography, a critical comparison (proceedings)].
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Adolescent↗
[The life of Joseph Haydn from a medical point of view (author's transl)].
Joseph Haydn (1732 to 1809) had hardly been troubled by any illness of note, apart from a chronic nasal polyp until 1799. During the composition of the oratoria "The Seasons" (1799 to 1801), the signs of cerebral arteriosclerosis with cardiac insufficiency made their appearance. Haydn's creative strength subsequently declined rapidly and he was virtually unable to compose any more after he had finished "The Seasons" until his death in 1809. The plan to compose a third oratoria "The Last Judgement" ended abortively. Haydn himself suffered acutely from the inactivity imposed on him by the illness, as documented by various sources. Hadyn remained fully conscious right up to the time of his death, which presumably resulted from cardiac failure. Haydn's grave was ransacked only a few days after the funeral and his skull was snatched. It has been finally restored to his resting place in Eisenstadt only as recently as 1954 after a protracted and devious journey.
Austria↗