Serial 99mTc diphosphonate bone scintigraphic studies of two patients with transitional cell carcinoma of the urinary bladder demonstrated gradually progressive renal dysfunction. The abnormalities in the last bone scan of each patient were compatible with the findings of the concurrent 131I hippuran and 99mTc-DTPA studies, and were presumably secondary to obstruction of the ureteral orifices by tumor in the urinary bladder. Progressive renal dysfunction may be reliably demonstrated by serial 99mTc diphosphonate bone scintigraphy.

Aged↗

PubMedDate not supplied

Hepatic visualization with a "hot" spot adjacent to the porta hepatis in Tc-99m MAA venography of the lower extremity: a sign of IVC obstruction.

A patient with suspected leg vein occlusion underwent 99mTc-MAA and 99mTc-pertechnetate venographies. The former study showed faint visualization of the liver associated with a large "hot" spot near the porta hepatis, a secondary sign of inferior vena cava obstruction, whereas the latter study did not demonstrate such findings. It is emphasized that the usage of 99mTc-MAA for venography, in addition to allowing detection of pulmonary embolism, has the advantage of visualization of the liver to strengthen the diagnosis of inferior vena cava obstruction.

Humans↗

PubMedDate not supplied

Disappearance of Tc-99m HMDP tumor uptake in oat cell carcinoma after irradiation and chemotherapy.

Extraosseous localization of bone-seeking radiopharmaceuticals has been reported in various tumors, presumably on the basis of active calcium deposition in the tumors. We report a case of oat cell carcinoma in which the initial localization of Tc-99m-HMDP in the tumor disappeared after irradiation and chemotherapy. The disappearance of tracer uptake coincided with regression of the mass as seen in the chest radiograph. This finding may have potential application in determining tumor response to anticancer therapy.

Antineoplastic Combined Chemotherapy Protocols↗

PubMedDate not supplied

99m-Tc HMDP bone scintigraphic findings of gouty arthropathy of both hands: extending soft tissue uptake adjacent to the joints.

The 99mTc hydroxy methylene diphosphonate scintigraphic findings of both hands are correlated to the radiographic findings in a patient with a 30-year history of gouty arthropathy. Scintigraphic differentiation of the type of arthritis on the basis of uptake pattern is difficult. However, the findings of rheumatoid arthritis are confined to the joints and usually the involvement is symmetrical. With gout there is a tendency toward asymmetrical, bilateral, multifocal joint involvement with areas of intense abnormal uptake; because of the associated soft tissue swelling, the intense uptake usually extends beyond the involved joints.

Arthritis↗