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Biomedical subjects

F H DeLand

Publications and source records attributed to F H DeLand.

At least 37 records · Page 2Linked to original sources
PubMed1986

Scintigraphic findings of multiple osteochondromas.

Multiple osteochondromas (hereditary multiple exostoses, diaphyseal aclasis, cartilagenous exostoses) are anomalies of bone development in which multiple cartilagenous exostoses grow out from the cortical surface, mainly involving ends of the long bones. While radiographic characteristics of multiple osteochondromas have been well documented, there is little information concerning the place of bone imaging in this disease. A patient with multiple osteochondromas whose skeletal scintigrams correlate with the concurrent radiographs is presented. Although there is no specific pattern scintigraphically, the abnormal, irregular increase in radioactivity at the end of the long bones may raise a possibility of this disease entity.

Adult↗
PubMed1986

Demonstration of pulmonary mass defect by iodine-123 N,N,N'trimethyl-N'[2-hydroxy-3-methyl-5-iodobenzyl]-1,3-propanediamine lung imaging.

A patient whose huge lung mass was demonstrated as a large defect on I-123 N,N,N'trimethyl-N'[2-hydroxy-3-methyl-5-iodobenzyl]-1,3-propanediamine (HIPDM) lung imaging is presented. I-123 HIPDM, a lipophilic agent, is designed for early detection of abnormal cerebral perfusion. Since up to 50% of the administered agent is accumulated and perhaps metabolized in the lung, the radiopharmaceutical may be potentially useful for detection of pathology of the lung in addition to evaluation of pulmonary amine metabolism.

Aged↗
PubMed1986

Flip-flop phenomenon in radiohippuran renal imaging. A sign of obstructive nephropathy.

In the dynamic radionuclide brain study, decreased flow in one cerebral hemisphere during the arterial phase followed by relatively increased radioactivity as compared with the contralateral hemisphere has been termed the flip-flop phenomenon, and reflects the development of collateral circulation to the affected side. In I-131 Hippuran renal imaging, relatively decreased activity in one kidney frequently is observed during the initial phase of the study, and is followed by a gradual increase of radioactivity in the late images when compared with the contralateral kidney. To evaluate the significance of this renal flip-flop phenomenon, the studies from 23 patients with these findings were retrospectively compared with the clinical data and findings from other diagnostic studies (CT, ultrasound, intravenous pyelogram, autopsy). Partial obstruction of the renal collecting system was found in all 23 patients. The causes were various malignant tumors in nine patients (colonic carcinoma, three patients; transitional cell carcinoma, three patients; prostatic carcinoma, two patients; seminoma, one patient), ureteropelvic obstruction in three patients, papillary necrosis in one patient, and ureteral fibrosis in one patient. The flip-flop phenomenon reflects asymmetric renal tubular function with decrease (prolonged parenchymal transit time) in the affected kidney as a result of ipsilateral obstruction of the collecting system, while contralateral renal function remains normal or relatively normal. The presence of the flip-flop phenomenon in an I-131 Hippuran renal study suggests the existence of some degree of collecting system obstruction that has persisted long enough to result in renal parenchymal damage.

Humans↗
PubMed1986

Intrathoracic abnormalities demonstrated by technetium-99m sulfur colloid imaging.

Since the scintillation camera enables us to include lower thorax in the views obtained during Tc-99m colloid imaging of the liver and spleen, intrathoracic pathology may be identified as relatively cold or hot areas in the thoracic cavity. Eighteen patients who underwent Tc-99m sulfur colloid imaging during a one-year period were found to have intrathoracic pathology demonstrated either as photopenic areas or as areas of increased radioactivity. These patients' clinical data and the results of other diagnostic modalities, including autopsy, were correlated with the Tc-99m images. The intrathoracic disease processes recognized were bacteremia, two cases; pleural effusion, two cases; lung pathology, one case; and cardiomegaly, 13 cases. With the Exception of two patients with bacteremia who had substantial radiocolloid sequestration by the lung, all the other patients had hepatic dysfunction. The presence of compromised hepatic function allows the visualization of intrathoracic abnormalities: photopenia suggesting pleural fluid collection or an enlarged cardiac silhouette (either photopenia or increased radioactivity occupying a large space in the anterior view to yield cardiothoracic ratio of greater than 50%). Therefore, Tc-99m sulfur during colloid liver-spleen imaging, patients with hepatic dysfunction may incidentally demonstrate intrathoracic pathology, especially cardiomegaly.

Aged↗
PubMed1986

Incidentally evaluating the status of renal function in technetium-99m DISIDA hepatobiliary imaging.

During hepatobiliary imaging studies, approximately 9% of Tc-99m DISIDA normally is excreted via the kidney. In routine 2, 5, 10, 15, 30, 45, and 60-minute images, the kidneys and urinary bladder are best visualized at 5-10 minutes and after 10-15 minutes, respectively. Nonvisualization of the kidney and/or urinary bladder may indicate renal dysfunction. To evaluate this hypothesis, Tc-99m DISIDA hepatobiliary images of 63 patients were correlated with concurrent serum BUN and creatinine levels (measured within 24 hours of the hepatobiliary study). Serum creatinine and BUN values were normal in patients with renal visualization. In patients without renal visualization, 17 of 19 had abnormal BUN and creatinine levels. The values of BUN and creatinine were significantly elevated (P less than 0.001) in patients without renal visualization when compared with those showing renal visualization. One patient had visualization of a single kidney due to a nephrectomy; in another, persistent visualization was due to hydronephrosis. Nonvisualization of the kidneys and/or urinary bladder suggests abnormal renal function, and asymmetric renal activity raises the possibility of renal disease.

Adult↗
PubMed1986

Localization of 99mTc-HMDP in hepatic metastases from colonic carcinoma.

To evaluate the significance and frequency of skeletal imaging agent localization in hepatic metastases from colonic carcinoma, scintigrams from 54 patients were retrospectively studied. Of 54 patients, 22 had hepatic metastases, and skeletal metastases were present in seven of 54. Six of the seven patients with skeletal metastases had concurrent hepatic deposits. Two patterns of bone agent localization in liver metastases occurred: diffuse and mild (10 patients) and ringlike in appearance (two patients). Twelve of the 22 patients had localization of skeletal imaging agent in hepatic metastases and extensive or large liver lesions. Concurrent serum calcium values for nine of 12 patients were reviewed; none had a high level of serum calcium. Among available plain films and /or CT scans of the abdomen for 21 of the 22 patients, only one patient with extensive colonic metastases had multiple calcifications shown on CT but not seen in plain films. The data indicate a high frequency of hepatic metastases in colon carcinoma (22/54, 40%) and a high frequency of skeletal imaging agent localization in the hepatic colonic metastases (12/22, 54.5%). Once skeletal metastases are observed, there are almost always hepatic metastases present (6/7). There was no relation between elevated serum calcium values and bone agent localization in hepatic deposits. The relation between skeletal imaging agent localization or radiographic calcifications and histopathology of colonic carcinoma was inconclusive. The presence of bone agent localization in a 99mTc hydroxymethylene diphosphonate (HMDP) bone study indicates colonic hepatic metastases that are substantially widespread and/or bulky.

Aged↗
PubMed1986

Radiocolloid scintigraphy in Felty's syndrome.

The Tc-99m sulfur colloid liver-spleen scintigrams of nine patients with Felty's syndrome (a triad of rheumatoid arthritis, splenomegaly, and neutropenia) were reviewed. The characteristic scintigraphic findings include (1) moderate or severe splenomegaly, (2) the reversal of liver-to-spleen uptake ratio despite normal liver function tests, and (3) virtually no visualization of the bone marrow uptake and no pulmonary radiocolloid sequestration. In a late stage of cirrhosis of the liver, moderate-to-severe splenomegaly with the reversal of liver-to-spleen uptake ratio almost always accompanies abnormal liver function, and sometimes there may be associated pulmonary radiocolloid uptake. It was therefore concluded that in a proper clinical setting, a radiocolloid scintigraph may differentiate between Felty's syndrome and cirrhosis of the liver in a late stage.

Aged↗
PubMed1986

Opportunistic intracranial infection in AIDS detection by technetium-99m DTPA brain scintigraphy.

Radionuclide brain scintigraphy and computed tomography (CT) demonstrated cerebral lesions in two patients with acquired immunodeficiency disease syndrome (AIDS) complicated by opportunistic infection of the brain. In the detection of these cerebral lesions, [99mTc]DTPA radionuclide scintigraphy was as reliable as CT. Since malignant lymphoma involving the brain has been seen with increasing frequency in patients with AIDS, the positive brain scan alone is nonspecific and should be correlated appropriately with the clinical setting.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Intracranial meningioma with abnormal localization of bone-seeking radiopharmaceutical: correlation with gross and microscopic pathology.

Meningioma is one of the neoplasms in which there may be extraosseous localization of bone-seeking radiopharmaceuticals. Tumor calcification, calvarial erosion, and the formation of reactive bone have been proposed as the cause of this abnormal tracer localization. We present a patient with a frontal meningioma that was evaluated using 99mTc-methylene-diphosphonate bone scintigraphy, head computed tomography, and skull radiography; the homogeneous density seen in the radiographic studies corresponded to the area of bone-seeking-agent localization shown in the scintigram. At autopsy, bony tissue and a few psammoma bodies were found in the meningioma, and apparently accounted for the bone-tracer localization. There was no calvarial erosion and no formation of reactive bone. If skull-radiographic studies show a homogeneous, radio-opaque lesion with no reactive changes in the adjacent skull, a meningioma showing a localization of a bone-seeking radiopharmaceutical may be predicted to have bone-tissue formation with or without psammoma bodies.

Aged↗
PubMed1985

Diagnosis and treatment of neoplasms with radionuclide-labeled antibodies.

The in vivo use of radionuclide-labeled antibodies to several types of tumor-associated antigens or products has proven to be a reliable method for defining primary, recurrent, metastatic, and occult carcinoma. Specificity for the radioimmunodetection procedure is high; however, the sensitivity varies depending on the size and site of the lesions. The relative roles of polyclonal- and monoclonal-type antibodies are still to be defined, since at this stage of development little difference can be demonstrated in the detection of tumor with either one. The introduction of emission computed tomography should simplify the imaging techniques appreciably and improve the resolution between nontarget and target radioactivity. Satisfactory radionuclide labels with photon energies more compatible with current imaging equipment will enhance resolution and sensitivity.

Animals↗
PubMed1985

Nonvisualization of an enlarged spleen on Ga-67 scintigraphy but demonstrated by CT after splenic irradiation.

Presence of enlarged spleen using CT with absence of splenic visualization in Ga-67 citrate images in a patient with chronic myelogenous leukemia and splenomegaly after splenic irradiation was observed. Since Howell-Jolly bodies had not been identified in the peripheral circulation, the finding of splenic nonvisualization was explained by disassociated splenic functions, which are not tightly coupled, and some activities that can be suppressed by irradiation without impairing others. The Ga-67 splenic localization mechanism is probably more sensitive and liable to disruption by irradiation, and was independent of spleen size. Ga-67 scintigraphy and Tc-99m sulfur colloid liver-spleen scintigraphy are two organ function-dependent imaging procedures, while CT provides anatomic information.

Gallium Radioisotopes↗
PubMed1985

Prominent gaseous distension of bowel causing false-positive technetium-99m sulfur colloid liver scintigram.

A Tc-99m sulfur colloid liver scan carried out shortly after a prolonged upper gastrointestinal endoscopy demonstrated two concave indentations along the inferior border of the liver and increased space between the left lobe of the liver and the spleen. These abnormalities, simulating compression by an extrinsic mass, were caused by air introduced endoscopically into the gastrointestinal tract. Eight days later, a repeat radiocolloid scan was normal. There should be awareness that gaseous distension of the bowel and stomach may result in a false-positive radiocolloid liver scan. Correlation with abdominal radiographs may avert such misinterpretation.

Aged↗
PubMed1985

Thallium-201 scintigraphic visualization at rest of a dilated and hypertrophied right ventricle in a patient with sarcoidosis complicated by cor pulmonale.

Visualization, by resting TI-201 scintigraphy, of a markedly enlarged right ventricle (RV) in a 48-year-old black man with a 20-year history of pulmonary sarcoidosis is presented. The RV was three to four times larger than the left ventricle. Sarcoidosis resulted in marked distortion of the thoracic contents, as shown by the radiograph. This distortion possibly accounts for optimal scintigraphic visualization of the enlarged RV in the left lateral projection rather than in the left anterior projection. Because of the distortion, the chest radiograph could not be used to evaluate the cardiac contour; TI-201 scintigraphy demonstrated the RV enlargement.

Cardiomegaly↗
PubMed1985

Scintigraphic findings in primary amyloidosis of the heart and stomach.

The effectiveness of scintigraphic studies in the study of patients with primary systemic amyloidosis has not been reported previously. This case report describes a patient with the scintigraphic findings of thickened myocardium and delayed gastric emptying, which correlated well with the presence of amyloid deposits in these organs at autopsy. Additionally, the liver and spleen had normal scintigraphic appearances and were free of amyloid at autopsy. Radionuclide studies appear useful in assessing the anatomic and physiologic abnormalities assessed by amyloid deposition.

Aged↗
PubMed1985

Technetium-99m triethylene tetramine polystyrene resin gastric emptying studies in patients with various upper gastrointestinal diseases.

The gastric emptying study using Tc-99m triethylene tetramine polystyrene resin with or without metoclopramide hydrochloride was used in six patients with different disease entities: achalasia, gastric lymphoma, primary amyloidosis, Zollinger-Ellison syndrome, duodenal diverticulum, and short bowel syndrome. All patients had abnormally prolonged gastric emptying times. The patient with gastric lymphoma and the patient with Zollinger-Ellison syndrome had virtually no effect from metoclopramide. The patient with a duodenal diverticulum and the patient with short bowel syndrome had partial and good response to metoclopramide, respectively. Endoscopic and/or autopsy examinations in patients with achalasia, Zollinger-Ellison syndrome, primary amyloidosis, and duodenal diverticulum proved the patency of the pyloric canal. The patient with gastric lymphoma had a mass associated with marked pyloric narrowing and lymphoma cell infiltration of the gastric wall, to explain the abnormal gastric emptying. The gastric emptying study with or without metoclopramide may be used noninvasively to measure gastric function, to determine the nature of gastric outlet obstruction, and to evaluate therapy with metoclopramide.

Adult↗